The Neuropathology Of Parkinson’S Disease

The Lewy body as a clue to the nerve cell degeneration
  • Lysia S. Forno


The etiology and pathogenesis of Parkinson’s disease have remained a mystery since the first description of the disease, but the neuropathology of the disorder, as we now know it, is fairly simple and straightforward. The most important lesion is in the substantia nigra pars compacta, where nerve cells degenerate together with their nigro-striatal fiber tract, causing a severe depletion of dopamine in the basal ganglia.


Tyrosine Hydroxylase Substantia Nigra Nerve Cell Lewy Body Neurofibrillary Tangle 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Lysia S. Forno
    • 1
    • 2
  1. 1.Departments of PathologyVeterans Administration Medical CenterPalo AltoUSA
  2. 2.Stanford University School of MedicineStanfordUSA

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