Mechanisms of MPP+ Neurotoxicity: Oxyradical and Mitochondrial Inhibition Hypotheses

  • Juan R. Sanchez-Ramos
  • Franz Hefti
  • Gary E. Hollinden
  • Thomas J. Sick
  • Myron Rosenthal


Recent studies demonstrate that 1-methyl-4-phenylpyridinium (MPP+) is selectively toxic to dopaminergic (DA) neurons. Investigations suggest that this selectivity results primarily from the affinity of MPP+ for the dopamine reuptake system which results in preferential accumulation of the toxin within the terminals of the nigrostriatal dopaminergic (DA) system (Javitch and Snyder, 1985;Pileblad and Carlssen, 1985; Mayer et al. 1986).


Tyrosine Hydroxylase Energy Failure Striatal Slice Gradual Leakage National Parkinson Foundation 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Juan R. Sanchez-Ramos
    • 1
  • Franz Hefti
    • 1
  • Gary E. Hollinden
    • 1
  • Thomas J. Sick
    • 1
  • Myron Rosenthal
    • 1
  1. 1.Dept. of NeurologyUniversity of Miami School of MedicineMiamiUSA

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