Studies on the Toxicity of MPTP to Dopamine Neurons in Tissue and Cell Cultures
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1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin with high specificity for the dopamine (DA) neurons of the nigrostriatal pathway of humans (Davis et al., 1979), monkeys (Burns et al., 1983) and mice (Heikkila et al., 1984a). In humans, the lesion which results from MPTP toxicity produces symptoms similar to idiopathic parkinsonism (Langston et al., 1983). The etiology of idiopathic parkinsonism remains still unknown and it is hoped that study of MPTP induced parkinsonism can elucidate the causes of this disease. Although it is possible that idiopathic parkinsonism bears no relationship with MPTP intoxication, knowledge of the cellular and molecular events that occur during MPTP induced neuronal degeneration would be a significant contribution to our understanding of neuronal susceptibility to environmental and/or endogenous neurotoxins.
KeywordsMonoamine Oxidase Dopamine Neuron Idiopathic Parkinsonism Dopaminergic Neurotoxicity Mesencephalic Neuron
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