Search For Environmental Or Endogenous Neurotoxins Related To MPTP
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The cause of Parkinson’s disease remains unknown despite clinical investigations of infectious, genetic, or other contributory etiologic factors (1). Neurotoxins have been considered as causative agents in past clinical investigations due particularly to the observations of parkinsonian symptomatology caused by manganese, 6-hydroxydopamine, neuroleptics, carbon monoxide, and carbon disulfide (2). The clinical responses to each of these neurotoxins differed distinctly from Parkinson’s disease, and thus when MPTP-induced neurotoxicity was first observed (3,4), it generated considerable interest because it closely paralleled the idiopathic disease condition in nearly every aspect. MPTP-induced parkinsonism in non-human primates differs from the idiopathic disease in humans only in its rapid course, the apparent lack of progression following the toxic insult, the absence of the neuropathological hallmark Lewy bodies, and the limited involvement of neurons other than the nigro-striatal in MPTP-affected animals (5). These observations have reawakened interest in a neurotoxic etiology of Parkinson’s disease and have enabled us to define new stategies and tools for these investigations.
KeywordsCerebellar Granule Cell Brain Extract Fluorescein Diacetate Cation Resin MPTP Toxicity
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- Duvoisin, R.C.: The cause of Parkinson’s disease. In: Movement Disorders, Chap. 2, Marsden, C.D., Fahn, S. (Eds.), Butterworth Scientific, London, pp. 8–24, 1987.Google Scholar
- Schwab, R.C., England, A.C., Jr.: Parkinson Syndromes due to various specific causes. In: Handbook Clin. Neurology, Chap. 9, Vinken, P.J., Bruyn, G.W. (Eds.), North Holland, pp. 227–247, 1968.Google Scholar
- Markey, S.P, Markey, C.J., Savitt, J.M., Bacon, J.P., Johannessen, J.N.: Search for environmental neurotoxins related to MPTP. Preparation of antibodies to MPTP and MPP+. In: MPTP — A Neurotoxin Producing A Parkinsonian Syndrome. Chap. 44, Markey, S.P, Castagnoli, N., Jr., Trevor, A.J., Kopin, I.J. (Eds.), Academic Press, Orlando, FL, pp. 487–493, 1986.Google Scholar
- Yang, S.C., Johannessen, J.N., Markey, S.P: Metabolism of 14C-[phenyl]-MPTP in mouse and monkey implicates MPP +, and not bound metabolites, as the operative neurotoxin. Submitted for publication.Google Scholar
- Novelli, A., Reilly, J. A., Lysko, PG., Henneberry, R.C.: Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced. Brain Res. (in press) 1988.Google Scholar