Chairmen Summary: Fundamental Aspects
Based upon epidemiological studies of occupational exposures certain nickel and chromium compounds and carcinogenesis bioassais of nickel, chromium and cobalt compounds in animals, as well as the outcome of in vitro tests for mutagenesis and genotoxicity, there is some reason to suspect that release of nickel, cobalt and chromium corrosion and wear particles from implanted prostheses could possibly constitute a carcinogenic hazard. Carcinogenic bioassais of cobalt and nickel metal powders in rodents have been positive, although chromium metal has given negative results under comparable experimental conditions. Only a few cases of sarcomas have been reported in patients at the sites of orthopaedic prostheses, so that the clinical evidence of carcinogenic hazards from Ni-Co-Cr prostheses is not convincing.
KeywordsOccupational Exposure Wear Particle Chromium Compound Chromium Metal Cobalt Compound
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