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The Toxicity of Chromium in the Zero and Trivalent Form

  • Chapter
Biocompatibility of Co-Cr-Ni Alloys

Part of the book series: NATO ASI Series ((NSSA,volume 171))

Abstract

Chromium is evaluated to contribute to a significant risk for the human health. But it is general accepted that the health effects of chromium for example irritation of skin and the upper respiratory tract, induction of contact hypersensitivity, of genotoxicity as well as the property to induce lung tumor and nephrotoxicity are mainly due to hexavalent chromium compounds exposed at very few occupational sites. In contrast trivalent chromium and chromium in the zero oxidation state are treated to be relatively ‘inert’ and not toxic to man and other species, because of their lower bioavailability (1–6). This paper will summarize the available data from literature on the acute and long-term exposure results of human and experimental studies.

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References

  1. Mertz, W.: Physiol.Rev. 49, 163–239 (1969).

    Google Scholar 

  2. IARC (International Agency for Research on Cancer) monographs on the evaluation of carcinogenic risk of chemicals to man. Vol.2, IARC, Lyon (1973).

    Google Scholar 

  3. Langard, S. & T. Norseth: Chapter 22 In: Friberg, L., G. F. Nordberg & V.B. Vouk (Edit): Handbook on the toxicology of metals. Elsevier/North-Holland Biochemical Press, Amsterdam, New York, Oxford (1979).

    Google Scholar 

  4. Hayes, R.B. In: Lilienfeld, A.H. (Edit.): Reviews in Cancer Epidemiology Vol 1. Elsevier/North-Holland Biochemical Press, Amsterdam, New York, Oxford (1980).

    Google Scholar 

  5. Korallus, U. & N. Leonhoff: Arbeitsmed. Sozialmed. Präventivemedizin 12, 285–289 (1981) (In German).

    Google Scholar 

  6. Hertel, R.F.: Staub-Reinhalt.Luft 42, 135–137 (1982) (In German).

    MathSciNet  Google Scholar 

  7. NAS/NRC: Recommended dietary allowances. 9th Edition. National Academy of Science, National Research Council, Washington, D.C. (1980).

    Google Scholar 

  8. Bonner, F.W. & D.V. Parke. Kapitel I 8b. In: Merian, E. (Edit): Metalle in der Umwelt. Verlag Chemie, Weinheim (1984) (In German).

    Google Scholar 

  9. Kieffer, F.: Sandoz Bulletin 52, 18–19 (1979).

    Google Scholar 

  10. Starich, G.H. & C. Blincoe: The Science of the Total Environment 28, 443–454 (1983).

    Article  Google Scholar 

  11. NIOSH (National Institute of Occupational Safety & Health) Registry of toxic effects of chemical substances. Cincinnati, Ohio 45226 (1983).

    Google Scholar 

  12. Bryson, W.G. & C.M. Goodall: Carcinogenisis 4, 1535–1539 (1983).

    Article  Google Scholar 

  13. Schroeder, H.A., J.J. Balassa & W.H. Vinton, Jr.: J. Nutrition 83, 239–250 (1964).

    Google Scholar 

  14. Ivankovic, S. & R. Preussmann: Food Cosmet. Toxicol. 13, 347–351 (1975).

    Article  Google Scholar 

  15. Sluis-Cremer, G.K. & R.S. Du Troit: Brit. J. Medicine 25, 63–67 (1968).

    Google Scholar 

  16. Mancuso, T.F. & W.C. Hueper: Ind.Med.Surg. 20, 358–363 (1951).

    Google Scholar 

  17. Princi, F., L.H. Miller, A. Davies & J. Cholak: J. Occup. Med. 4, 301–310 (1962).

    Google Scholar 

  18. Davies, J.C.A.: Centr. Africa J. Med. 20, 140–143 (1974).

    Google Scholar 

  19. Langard, S.: Int. Arch. Occup. Environ. Health 46, 1–9 (1980).

    Article  Google Scholar 

  20. Roschina, T.A.: Gig. tr. prof. zabol. 4, 28–32 (1959) (In Russian).

    Google Scholar 

  21. Blokin, V.S. & F.S. Trop: In: N.P. Dubinin (Edit.): Genetic effects of the pollution of the environment. Moscow, Nauka, pp. 173–176 (1977) (In Russian).

    Google Scholar 

  22. Kämmerer, H. & H. Michel: Allergische Diathese und allergische Erkrankungen. Bergmann, München, 3. Auflage (1956) (In German).

    Book  Google Scholar 

  23. Morris, G.E.: A.H.A. Arch. Derm. (Chicago) 78, 612–618 (1958).

    Article  Google Scholar 

  24. Fregert, S. & H. Rorsman: Arch. Derm 91, 233–234 (1965).

    Article  Google Scholar 

  25. Polak, L., J.L. Turk & J.R. Frey: Prog. Allergy 17, 145–226 (1973).

    Google Scholar 

  26. Zelger, J.: Arch. Klin. Exp. Derm. 218, 499 (1964) (In German).

    Google Scholar 

  27. Marzulli, F.N. & H.J. Maibach: Chapter 13. In: Marzulli, F.N. & H.I. Maibach (Edit): Dermatotoxicology, Hemisphere Publishing Corporation, Washington, New York, London (1983).

    Google Scholar 

  28. Kligman, A.M.: J. Invest. Dermatol. 47, 393–409 (1966).

    Google Scholar 

  29. Bockendahl, H.: Derm. Wschr. 130, 987. (1954) (In German).

    Google Scholar 

  30. Samitz, M.H., S.A. Katz, D.M. Scheiner & P.R. Gross: Acta derm.-venereol. 49, 142–146 (1969).

    Google Scholar 

  31. Coleman, R.F., J. Harrington & F.T. Scales: Brit. Med. J. i, 527–529 (1973).

    Article  Google Scholar 

  32. Evans, E.M., M.A.R. Freeman, A.J. Miller & B. Vernon-Roberts: J.Bone Jt. Surg. 56 B, 626–642 (1974).

    Google Scholar 

  33. Minski, M.J. & H.S. Dobbs: In Brätter, P. & P. Schramel (Edit): Trace element analytical chemistry in medicine and biology. De Gruyter & Co., Berlin, New York (1980).

    Google Scholar 

  34. Elves, M.W., J.N. Wilson, J.E. Seales & H.B.S. Kemp: Brit. Med. J. 4, 376–378 (1975).

    Article  Google Scholar 

  35. Munro-Ashman, D. & A.J. Miller: Contact Dermatitis 2, 65–67 (1976).

    Article  Google Scholar 

  36. Clark, R. & G. Kunitsch: Berufsdermatosen 20, 222–238 (1972) (In German).

    Google Scholar 

  37. Kelly, W.F., P. Ackrill, J.P. Day, M. Ottara, C.T. Tye, J. Burton, C. Orton & M. Harris: Brit. J. Ind. Med. 39, 397–400 (1982).

    Google Scholar 

  38. Matsumoto, N., S. Iijima & H. Katsunuma: J. Toxicol, Sci. 2, 1–13 (1976)

    Article  Google Scholar 

  39. Danielsson, B.R.G., E. Hassoun & L. Dencker: Arch. Toxicol. 51, 233–245 (1982).

    Google Scholar 

  40. Wacker, W.E.C. & B.L. Vallee: J.Biol.Chem. 234, 3257–3262 (1959).

    Google Scholar 

  41. Susa, N., J. Furukawa & S. Tsubaki: Jap.J.Vet.Sci 39, 325–336 (1977).

    Article  Google Scholar 

  42. Vernier, P., A. Montaldi, F. Majone, V. Bianchi & A.G. Levis: Carcinogensis 3, 1331–1338 (1982).

    Article  Google Scholar 

  43. Leonard, A. & R.R. Lauwerys: Mutation Research 76, 227–239 (1980).

    Article  Google Scholar 

  44. Baker, R.S.U.: Toxicol. & Environm. Chem. 7, 191–212 (1984).

    Article  Google Scholar 

  45. Langard, S.: Chapter 2 In: Burrows, D. (Edit.): Chromium: Metabolism and toxicity. CRC Press Inc., Boca Raton, Florida (1983).

    Google Scholar 

  46. Pedley, B., G. Meachim & D.F. Williams: In Willams, D.F. (Edit.): Fundamental Aspects of Biocompatibiliby. CRC Press Inc., Boca Raton, Florida (1981).

    Google Scholar 

  47. Hueper, W.C.: J. Nat. Cancer Institute 16, 447–462 (1955).

    Google Scholar 

  48. Sundermann, F.W.Jr., T.J. Lan & L.J. Cralley: Cancer Res. 34, 92–95 (1974).

    Google Scholar 

  49. Mukubo, K.: J. Nara.Med.Assoc. 29, 321–340 (1978).

    Google Scholar 

  50. Heath, J.C., M.A.R. Freeman and S.A.V. Swanson: Lancet 1, 564–566 (1971).

    Article  Google Scholar 

  51. Payne, W.W.: Arch. Environ. Health, 1, 20–26 (1960).

    Google Scholar 

  52. Hueper, W.C.: Arch. Ind. Hlth. 18, 284–291 (1958).

    Google Scholar 

  53. Hueper, W.C.: Cancer Res. 21, 842–857 (1961).

    Google Scholar 

  54. Hueper, W.C. & W.W. Payne: Arch. Environ Hlth 5, 445–462 (1962).

    Google Scholar 

  55. Kuschner, M. & S. Laskin: Amer. J. Pathol 64, 183–191 (1971).

    Google Scholar 

  56. Laskin, S., M. Kuschner & R.T. Drews: in Hauna et al. (Edit.): Inhalation Carcinogenesis, US Atomic Energy Commission, Div. Techn. Inform. Extension pp. 321–351 (1970).

    Google Scholar 

  57. Dvizhkov, P.P. & V.J. Fedorova: Vop. Onkol. 13, 57–62 (1967).

    Google Scholar 

  58. Stoner, G.D., M.B. Shimkin, M.C. Troxell, T.L. Thompson & L.S. Terry: Cancer Res. 36 1744–1747 (1976).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Fraunhofer Institute for Environmental Chemistry and Ecotoxicology, D-5948, Schmallenberg-Grafschaft, F.R. Germany

    U. Glaser

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  1. U. Glaser
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Editor information

Editors and Affiliations

  1. Institute of Occupational Medicine, Lille, France

    Hartmut F. Hildebrand

  2. University Hospital Center of Strasbourg, Strasbourg, France

    Maxime Champy

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© 1988 Plenum Press, New York

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Glaser, U. (1988). The Toxicity of Chromium in the Zero and Trivalent Form. In: Hildebrand, H.F., Champy, M. (eds) Biocompatibility of Co-Cr-Ni Alloys. NATO ASI Series, vol 171. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0757-0_3

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  • DOI: https://doi.org/10.1007/978-1-4613-0757-0_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8067-5

  • Online ISBN: 978-1-4613-0757-0

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