Abstract
The cell division cycle of the budding yeast Saccharomyces cerevisiae is controlled during the G1 phase by a complex series of events designated as START. During START the yeast cell monitors its size and integrates nutritional and/or pheromonal signals in order to decide whether to stay in a resting state (G), to sporulate (in a diploid state), to conjugate or to start a new round of division. START is controlled by several cell division cycle (CDC) genes, and two groups of temperature-sensitive cdc mutants arrest upon shift to restrictive temperature (37°) either prior to the pheromone-sensitive step (group A, including cdc25 and cdc35) or after this step (group B, including cdc28) as stationary-like, round, unbudded and uninuclear cells (Pringle and Hartwell, 1981). Group A START mutants are unable to grow at 37°, do not form a spindle pole body satellite, and are unable to conjugate, and at least two mutants of this group (cdc25 and cdc35) can enter the meiotic pathway in a fully complemented medium, if in a diploid state, whereas start of mitosis is blocked (Shilo et al., 1978).
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© 1988 Plenum Press, New York
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Küntzel, H. et al. (1988). Control of the Cell Cycle Start by Protein Kinase Genes in Saccharomyces Cerevisiae . In: Zelinka, J., Balan, J. (eds) Metabolism and Enzymology of Nucleic Acids. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0749-5_18
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DOI: https://doi.org/10.1007/978-1-4613-0749-5_18
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