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Testing Animal Behavioral Teratogens

Designs and Methods

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Behavioral Teratogenesis and Behavioral Mutagenesis
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Abstract

Mark Twain observed that “man is the only animal that blushes. Or needs to.” Trying to develop an animal model for blushing would therefore be pointless from both a physiological and a psychological perspective. Fortunately animals resemble humans in other ways, and these resemblances can be used to make inferences about the human condition. While such inferences are always tenuous, the more closely the results of animal studies resemble observations in humans, the more confident we can be in drawing other inferences from animals to humans. The bottom lines in animal research are (1) how similar animals are to humans in their reaction to the same conditions and, (2) how similar are the methods used in animal and human research.

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References

  • Abbey, H., and Howard, E. Statistical procedure in developmental studies on a species with multiple offspring. Developmental Psychobiology, 1973, 6, 329–335.

    Article  PubMed  CAS  Google Scholar 

  • Abel, E. L. Effects of alcohol withdrawal and undernutrition in cannibalism of rat pups. Behavior and Neural Biology, 1979a, 25, 411–413.

    Article  CAS  Google Scholar 

  • Abel, E. L. Prenatal effects of alcohol on adult learning in rats. Pharmacology, Biochemistry and Behavior, 1979b, 10, 239–243.

    Article  CAS  Google Scholar 

  • Abel, E. L. Behavioral teratology of alcohol. Psychological Bulletin, 1981, 90, 564–581.

    Article  PubMed  CAS  Google Scholar 

  • Abel, E. L. In utero alcohol exposure and developmental delay of response inhibition. Alcoholism: Clinical and Experimental Research, 1982, 6, 369–376.

    Article  CAS  Google Scholar 

  • Abel, E. L. Fetal Alcohol Syndrome and Fetal Alcohol Effects. New York: Plenum Press, 1984.

    Google Scholar 

  • Abel, E. L., Bush, R., and Dintcheff, B. A. Exposure of rats to alcohol alters drug sensitivity during adulthood. Science, 1981, 272, 1531–1533.

    Article  Google Scholar 

  • Abel, E. L., and Dintcheff, B. A. Effects of prenatal alcohol exposure on growth and development in rats. Journal of Pharmacology Experimental Therapeutics, 1978, 277, 916–921.

    Google Scholar 

  • Abel, E. L., and Dintcheff, B. A. Effects of prenatal alcohol exposure on behavior of aged rats. Drug and Alcohol Dependence, 1986, 16, 321–330.

    Article  PubMed  CAS  Google Scholar 

  • Abel, E. L., and Greizerstein, H. B. Ethanol-induced prenatal growth deficiency: Changes in fetal body composition. Journal of Pharmacology and Experimental Therapeutics, 1979, 211, 668–671.

    PubMed  CAS  Google Scholar 

  • Adams, J. Clinical relevance of experimental behavioral teratology. Neurotoxicology, 1986a, 7, 19–34.

    PubMed  CAS  Google Scholar 

  • Adams, J. Methods in behavioral teratology. In E. P. Riley and C. V. Vorhees (Eds.), Handbook of Behavioral Teratology. New York: Plenum Press, 1986b, pp.67–97.

    Chapter  Google Scholar 

  • Anderson, B. J., Nash, S. M., Weaver, M. S., and Davis, S. F. Defensive burying: The effects of multiple stimulus presentation and extinction. Psychological Record, 1983, 33, 185–190.

    Google Scholar 

  • Barone, E. R., Pirola, C., and Lieber, C. S. Small intestinal damage and changes in cell population produced by ethanol ingestion in the rat. Gastroenterology, 1914, 66, 226–234.

    Google Scholar 

  • Browning, R. A., Nelson, D. K., Mogharreban, N., Jobe, P. C., and Laird, H. E. Effect of midbrain and pontine ligmental lesions on audiogenic seizures in genetically epilepsy prone rats. Epilepsia, 1985, 126, 1175–1183.

    Google Scholar 

  • Buelke-Sam, J., and Kimmel, C. A. Development and standardization of screening methods for behavioral teratology. Teratology, 1979, 20, 17–29.

    Article  PubMed  CAS  Google Scholar 

  • Buelke-Sam, J., Kimmel, C. A., Adams, J., Nelson, C. J., Vorhees, C. V., Wright, D. C., St. Omer, V., Korol, B. A., Butcher, R. E., and Wayner, M. J. Collaborative behavioral teratology study: Results. Neurobehavioral Toxicology and Teratology, 1985, 7, 591–624.

    PubMed  CAS  Google Scholar 

  • Burkhalter, J. E., and Balter, R. L. Behavioral teratology evaluation of trichloromethane in mice. Neurobehavioral Toxicology, 1979, 1, 199–205.

    PubMed  CAS  Google Scholar 

  • Butcher, R. E. Behavioral testing as a method for assessing risk. Environmental Health Perspectives, 1976, 18, 75–78.

    Article  PubMed  CAS  Google Scholar 

  • Cravens, R. W. Effects of maternal undernutrition on offspring behavior: Incentive value of a food reward and ability to escape from water. Developmental Psychobiology, 1974, 7, 61–69.

    Article  PubMed  CAS  Google Scholar 

  • Dalterio, S. L. Perinatal and adult exposure to cannabinoids alters male reproductive functions in mice. Pharmacology, Biochemistry and Behavior, 1980, 12, 143–153.

    Article  CAS  Google Scholar 

  • Davis, M. Habituation and sensitization of a startle-like response elicited by electrical stimulation at different points in the acoustic startle circuit. Advances in Physiological Science. 1980, 16, 67–68.

    Google Scholar 

  • Dinsmoor, J. A. Operant conditioning. In J. B. Sidowski, (Ed.), Experimental Methods and Instrumentation in Psychology. New York: McGrankell, 1966, pp. 421–445.

    Google Scholar 

  • Douglas, R. J. The hippocampus and behavior. Psychological Bulletin, 1967, 67, 416–442.

    Article  PubMed  CAS  Google Scholar 

  • Fox, M. W. Reflex-ontogeny and behavioral development of the mouse. Animal Behavior, 1965, 13, 234–241.

    Article  CAS  Google Scholar 

  • Gallo, P. V., and Weinberg, J. Neuromotor development and response inhibition following prenatal ethanol exposure. Neurobehavioral Toxicology and Teratology, 1982, 4, 505–513.

    PubMed  CAS  Google Scholar 

  • Golub, M., and Kornetsky, C. Seizure susceptibility and avoidance conditioning in adult rats treated prenatally with chlorpromazine. Developmental Psychobiology, 1974, 7, 79–88.

    Article  PubMed  CAS  Google Scholar 

  • Gottfried, E. B., Korsten, M. A., and Lieber, C. S. Gastritis and duodenitis induced by alcohol: An endoscopic and histologic assessment. Gastroenterology, 1976, 70, 890.

    Google Scholar 

  • Greizerstein, H. B., and Abel, E. L. Acute effects of ethanol on fetal body composition and electrolyte content in the rat. Bulletin of the Psychonomic Society, 1979, 14, 355–356.

    CAS  Google Scholar 

  • Hanshaw, J. B., Dudgeon, J. A., and Marshall, W. C. Viral Diseases of the Fetus and Newborn. Philadelphia: W. B. Saunders, 1985.

    Google Scholar 

  • Hard, E., Dahlgren, I. L., Engel, J., Larson, K., Liljequest, S., Linch, A., and Musi, B. Development of sexual behavior in prenatally ethanol-exposed rats. Drug and Alcohol Dependence, 1984, 14, 51–61.

    Article  PubMed  CAS  Google Scholar 

  • Harris, R. P., and Case, J. Effects of maternal consumption of ethanol, barbital, or chlordiazepoxide on the behavior of offspring. Behavioral and Neural Biology, 1979, 26, 234–247.

    Article  PubMed  CAS  Google Scholar 

  • Irwin, S. Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse. Psychopharmacology, 1968, 13, 222–257.

    Article  CAS  Google Scholar 

  • Jobe, P. C., Picchioni, A. L., and Chin, L. Role of brain norepinephrine in audiogenic seizure in the rat. Journal of Pharmacology and Experimental Therapeutics, 1973, 184, 1–10.

    PubMed  CAS  Google Scholar 

  • Kesner, R. P. Subcortical mechanisms of audiogenic seizures. Experimental Neurology, 1966, 15, 192–205.

    Article  PubMed  CAS  Google Scholar 

  • Leichter, J., and Lee, M. Effect of maternal ethanol administration on physical growth of the offspring in rats. Growth, 1979, 43, 288–297.

    PubMed  CAS  Google Scholar 

  • Levine, S. Stimulation in infancy. Scientific American, 1960, 202, 80–86.

    Article  Google Scholar 

  • Lichtensteiger, W., and Schlumpf, M. Prenatal nicotine affects fetal testesterone and sexual dimorphism of saccharin preference. Pharmacology, Biochemistry and Behavior, 1985, 23, 439–444.

    Article  CAS  Google Scholar 

  • Lieber, C. S. Alcohol-nutrition interactions. In T. K. Li, S. Schenker, and L. Luming, (Eds.), Alcohol and Nutrition. Rockville, Md.; U.S. Department of Health, Education and Welfare, 1979, pp. 47–63.

    Google Scholar 

  • Lochry, E. A., Hoberman, A. M., and Christian, M. S. Comparative sensitivity of pups’ bodyweight and commonly used developmental landmarks. Teratology, 1985, 32, 28A.

    Google Scholar 

  • Martin, J. C., Martin, D. C., Sigman, G., and Radow, B. Maternal ethanol consumption and hyperactivity in crossfostered offspring. Physiological Psychology, 1978, 6, 362–365.

    Google Scholar 

  • McGivern, R. F., Clancy, A. N., Hill, M. A., and Noble, E. P. Prenatal alcohol exposure alters adult expression of sexually dimorphic behavior in the rat. Science, 1984, 224, 896–898.

    Article  PubMed  CAS  Google Scholar 

  • Means, L. W., Medlin, C. W., Highes, V. D. and Gray, S. L. Rats exposed in utero to ethanol are hyperresponsive to methylphenidate when tested as neonates. Neurobehavioral Toxicology and Teratology, 1984, 6, 187–192.

    PubMed  CAS  Google Scholar 

  • Meyer, L. S., and Riley, E. P. In E. P. Riley, and C. V. Vorhees (Eds.), Handbook of Behavioral Teratology. New York: Plenum Press, 1986, pp. 101–140.

    Chapter  Google Scholar 

  • Middaugh, L. D., Santos, C. A., and Zemp, J. W. Effects of phenobarbital given to pregnant mice on behavior of mature offspring. Developmental Psychobiology, 1975, 8, 305–313.

    Article  PubMed  CAS  Google Scholar 

  • Miller, B. M. (Ed). Laboratory Safety: Principles and Practices. Washington, DC, American Society for Microbiology, 1986.

    Google Scholar 

  • Mowrer, O. H., and Lamoreaux, R. R. Fear as an intervening variable in avoidance conditioning. Journal of Comparative Psychology, 1946, 39, 29–50.

    Article  PubMed  CAS  Google Scholar 

  • Munn, W. L. Handbook of Psychological Research on the Rat. Boston: Houghton Mifflin, 1950.

    Google Scholar 

  • O’Callaghan, J. P. and Holtzman, S. G. Prenatal administration of levorphanol or dextromethorphan to the rat: Analgesic effect of morphine in the offspring. Journal of Pharmacology and Experimental Therapeutics, 1977, 200, 255–262.

    PubMed  Google Scholar 

  • Ossenkopp, K., and Mazmanian, D. S. The measurement and integration of behavioral variables: Aggregation and complexity as important issues. Neurobehavioral Toxicology and Teratology, 1985, 7, 95–100.

    PubMed  CAS  Google Scholar 

  • Palmer, A. K. The design of subprimate animal studies. In J. G. Wilson and F. C. Fraser (Eds.), Handbook of Teratology (Vol. 4). New York: Plenum Press, 1977, pp. 215–253.

    Google Scholar 

  • Pinel, J. P. J., and Treit, D. Burying as a defensive response in rats. Journal of Comparative and Physiological Psychology, 1978, 92, 708–712.

    Article  Google Scholar 

  • Pizzi, W. J., Unnerstall, J. R., and Barnhardt, J. E. Neonatal monosodium glutamate administration increases susceptibility to chemically-induced convulsions in adult mice. Neurobehavioral Toxicology and Teratology, 1979, 1, 169–173.

    CAS  Google Scholar 

  • Reiter, L. W., and Macphail, R. C. A Motor activity: survey of methods with potential use in toxicity testing. Neurobehavioral Toxicology and Teratology, 1979, 1 (Suppl.), 53–66.

    CAS  Google Scholar 

  • Riley, E. P., Lochry, E. A., and Shapiro, N. R. Lack of response inhibition in rats prenatally exposed to alcohol. Psychopharmacology, 1979, 62, 47–52.

    Article  PubMed  CAS  Google Scholar 

  • Riley, E. P., Lochry, E. A., Shapiro, N. R., and Baldwin, J. Response perseveration in rats exposed to alcohol prenatally. Pharmacology, Biochemistry and Behavior, 1979, 10, 255–259.

    Article  CAS  Google Scholar 

  • Riley, E. P., and Meyer, L. S. Considerations for the design, implementation, and interpretation of animal models of fetal alcohol effects. Neurobehavioral Toxicology and Teratology, 1984, 6, 97–101.

    PubMed  CAS  Google Scholar 

  • Sandberg, P. R., Hagenmeyer, S. H., and Henault, M. A. Automated measurement in multivariate locomotor behavior in rodents. Neurobehavioral Toxicology and Teratology, 1985, 7, 87–94.

    Google Scholar 

  • Servit, Z. The role of subcortical acoustic centers in seizure susceptibility to an acoustic stimulus in symptomatology of audiogenic seizures in the rat. Physiologia Bohemoslovia, 1960, 9, 42–47.

    Google Scholar 

  • Smith, J. C. Marginal nutritional states and conditioned deficiencies. In T. K. Li, S. Schenker, and L. Lumeng, (Eds.), Alcohol and Nutrition. Rockville, Md.: U.S. Department of Health, Education and Welfare, 1979, pp. 23–46.

    Google Scholar 

  • Teicher, M. H., Pearson, D. E., Shaywitz, B. A., and Cohen, D. J. Identifying experimental units and calculating experimental error. Science, 1981, 213, 931.

    Article  PubMed  CAS  Google Scholar 

  • United States Protection Agency. Toxic substances control act test guidelines; final rules, 40 CFR Part 798. 6200: Health effects testing guidelines, neurotoxicity, motor activity. Federal Register, 1985, 50, 39460.

    Google Scholar 

  • Valenstein, E. S., Kakolewski, J. W., and Cox, C. V. Sex differences in taste preference for glucose and saccharin solutions. Science, 1961, 156, 942–943.

    Article  Google Scholar 

  • Vorhees, C. V. Fetal anticonvulsant syndrome in rats: Dose-and period-response relationships of prenatal diphenylhydantoin, trimethadione and phénobarbital exposure on the structural and functional development of the offspring. Journal of Pharmacology and Experimental Therapeutics, 1983, 227, 274–287.

    PubMed  CAS  Google Scholar 

  • Wade, G. N., and Zucker, I. Taste preferences of female rats. Physiology and Behavior, 1969, 4, 935–943.

    Article  CAS  Google Scholar 

  • Walsh, R. N., and Cummins, R. A. The open-field test: A critical review. Psychology Bulletin, 1976, 83, 482–504.

    Article  CAS  Google Scholar 

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© 1989 Plenum Press, New York

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Abel, E.L. (1989). Testing Animal Behavioral Teratogens. In: Behavioral Teratogenesis and Behavioral Mutagenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0735-8_7

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  • DOI: https://doi.org/10.1007/978-1-4613-0735-8_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8056-9

  • Online ISBN: 978-1-4613-0735-8

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