Genetic HDL Deficiency States

  • J. M. Ordovas
  • D. C. King
  • E. J. Schaefer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 243)

Abstract

Barr et al (1) were the first investigators to document a relationship between decreased high density lipoprotein (HDL) cholesterol concentrations and coronary artery disease (CAD). Subsequently in 1966 Gofman et al. in a prospective study (2) found a similar association of plasma HDL levels with disease. This concept was not properly recognized until Miller and Miller published their work in 1975 (3). In 1977 two more studies, Framingham (4) and Tromso (5) provided further evidence of the inverse relationship between levels of HDL in plasma and risk of CAD.

Keywords

Cholesterol Lipase Cysteine Electrophoresis Neuropathy 

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. M. Ordovas
    • 1
  • D. C. King
    • 1
  • E. J. Schaefer
    • 1
  1. 1.Lipid Metabolism LaboratoryUSDA Human Nutrition Research Center on Aging at Tufts UniversityBostonUSA

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