Genetic HDL Deficiency States

  • J. M. Ordovas
  • D. C. King
  • E. J. Schaefer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 243)


Barr et al (1) were the first investigators to document a relationship between decreased high density lipoprotein (HDL) cholesterol concentrations and coronary artery disease (CAD). Subsequently in 1966 Gofman et al. in a prospective study (2) found a similar association of plasma HDL levels with disease. This concept was not properly recognized until Miller and Miller published their work in 1975 (3). In 1977 two more studies, Framingham (4) and Tromso (5) provided further evidence of the inverse relationship between levels of HDL in plasma and risk of CAD.


High Density Lipoprotein Premature Coronary Artery Disease Plasma High Density Lipoprotein High Density Lipoprotein Particle Tangier Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. M. Ordovas
    • 1
  • D. C. King
    • 1
  • E. J. Schaefer
    • 1
  1. 1.Lipid Metabolism LaboratoryUSDA Human Nutrition Research Center on Aging at Tufts UniversityBostonUSA

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