Arterial Cell Interactions: Mechanistic Studies Related to Eicosanoid and Growth Factor-Induced Alterations in Cholesterol Metabolism

  • David P. Hajjar
  • Aaron J. Marcus
  • Kenneth B. Pomerantz
  • Katherine A. Hajjar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 243)


Intracellular cholesterol accumulation in the arterial wall and the proliferation of intimal smooth muscle cells are the hallmarks of atherogenesis. Humoral fluid-phase interactions between arterial endothelial and smooth muscle cells have been studied in vivo and in vitro in an attempt to delineate whether these cells communicate in the regulation of intimal hyperplasia and cholesterol and lipoprotein metabolism in arterial smooth muscle cells.


Smooth Muscle Cell Cholesteryl Ester Cholesterol Metabolism Arterial Smooth Muscle Cell Cholesteryl Ester Hydrolase 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • David P. Hajjar
    • 1
  • Aaron J. Marcus
    • 2
    • 4
  • Kenneth B. Pomerantz
    • 2
  • Katherine A. Hajjar
    • 2
    • 3
  1. 1.Department of BiochemistryCornell University Medical CollegeUSA
  2. 2.Department of MedicineCornell University Medical CollegeUSA
  3. 3.Department of PathologyCornell University Medical CollegeUSA
  4. 4.Department of PediatricsCornell University Medical CollegeUSA

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