Abstract
Trauma to blood vessels or degenerative changes in atherosclerotic plaques result in exposure of structures in the subendothelium, such as collagen, which in its native state is stimulatory for platelet adhesion and subsequent activation (Marcus, 1988). Platelet activation is also accompanied by initiation of the blood coagulation cascade, culminating in the formation of thrombin. Collagen and thrombin are capable of stimulating the oxygenation of free arachidonate, thereby activating the eicosanoid pathway in both platelets and endothelial cells. Many of the eicosanoids which form are actually autacoids with significant biological properties.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bjorkhem, I., and Danielsson, H., 1970, Omega- and (omega-l)-oxidation of fatty acids by rat liver microsomes, Eur. J. Biochem., 17:450.
Hansson, G., Lindgren, J.A., Dahlen, S.-E., Hedqvist, P., and Samuelsson, B., 1981, Identification and biological activity of novel omega-oxidized metabolites of leukotriene B4 from human leukocytes, FEBS Lett., 130:107.
Jubiz, W., Radmark, 0., Malmsten, C., Hansson, G., Lindgren, J.A., Palmblad, J., Uden, A.-M., and Samuelsson, B., 1982, A novel leukotriene produced by stimulation of leukocytes with formylmethionylleucylphenylalanine, J. Biol. Chem., 257:6106.
Kamei, S., Wakabayashi, K., and Shimazono, N., 1964, Studies on omega-oxidation of fatty acids in vitro, J. Biochem. (Tokyo), 56:72.
Marcus, A.J., Weksler, B.B., Jaffe, E.A., and Broekman, M.J., 1980, Synthesis of prostacyclin from platelet-derived endoperoxides by cultured human endothelial cells, J. Clin. Invest., 66:979.
Marcus, A.J., Safier, L.B., Ullman, H.L., Broekman, M.J., Islam, N., Oglesby, T.D., and Gorman, R.R., 1984, 12S,20-Dihydroxyicosatetraenoic acid: a new icosanoid synthesized by neutrophils from 12S-hydroxyicosatetraenoic acid produced by thrombin- or collagen- stimulated platelets, Proc. Natl. Acad. Sci. U.S.A., 81:903.
Marcus, A.J., 1986, Transcellular metabolism of eicosanoids, in: “Progress in Hemostasis and Thrombosis,” B.S. Coller, ed., Grune & Stratton, New York.
Marcus, A.J., Safier, L.B., Ullman, H.L., Islam, N., Broekman, M.J. and von Schacky, C., 1987, Studies on the mechanism of omega-hydroxylation of platelet 12-hydroxyeicosatetraenoic acid (12-HETE) by unstimulated neutrophils, J. Clin. Invest., 79:179.
Marcus, A.J., Safier, L.B., Ullman, H.L., Islam, N., Broekman, M.J., Falck, J.R., Fischer, S., and von Schacky, C., 1988, Platelet-neutrophil interactions, 12S-hydroxyeicosatetraen-1,20-dioic acid: a new eicosanoid synthesized by unstimulated neutrophils from 12S,20-dihydroxyeicosatetraenoic acid, J. Biol. Chem., 263:2223.
Marcus, A.J., 1988, Hemorrhagic disorders: abnormalities of platelet and vascular function, in:“Cecil Textbook of Medicine, 18th Edition,” J.B. Wyngaarden and L.H. Smith, Jr., eds., Saunders, Philadelphia.
Marcus, A.J., 1988, Eicosanoids: transcellular metabolism, in: “Inflammation: basic principles and clinical correlates,” J.I. Gallin, I.M. Goldstein, and R. Snyderman, eds., Raven Press, New York.
Mitz, M.A., and Heinrikson, R.L., 1961, Omega hydroxy fatty acid dehydrogenase, Biochem. Biophys. Acta, 46:45.
Morrison, R.T., and Boyd, R.N., 1983, “Organic Chemistry,” 4th Edition, Allyn and Bacon, Inc., Boston.
Powell, W.S., 1984, Properties of leukotriene B4 20-hydroxy1ase from polymorphonuclear leukocytes, J. Biol. Chem., 259:3082.
Shak, S., and Goldstein, I.M., 1984, Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes, J. Biol* Chem., 259:10181.
Shak, S., and Goldstein, I.M., 1985, Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes, J. Clin. Invest., 76:1218.
Soberman, R.J., Harper, T.W., Murphy, R.C., and Austen, K.F., 1985, Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes, Proc. Natl. Acad. Sci. U.S.A., 82:2292.
Wakabayashi, K., and Shimazono, N., 1961, Studies in vitro on the mechanism of omega-oxidation of fatty acids, Biochim. Biophys. Acta, 48:615.
Wakabayashi, K., Kamei, S., Murakami, H., and Shimazono, N., 1962, On the presence of omega-hydroxyfatty acid: NAD oxidoreductase, J. Biochem. (Tokyo), 52:464.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Marcus, A.J. et al. (1988). Platelet-Neutrophil Interactions in the Eicosanoid Pathway. In: Malmendier, C.L., Alaupovic, P. (eds) Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 243. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0733-4_4
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0733-4_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8055-2
Online ISBN: 978-1-4613-0733-4
eBook Packages: Springer Book Archive