Abstract
Two papers on apo C-II and apo C-III metabolism have been published in 1981 and 1982 (1,2), only one comparing normal and hypeirlipoproteinemic subjects (1). The kinetic analysis of 1 2 5l labeled VLDL was followed in plasma for 48 h only and there were no urine data. The essential limitation of these early studies was their short duration due to the low specific activity of each individual C peptide obtained after whole VLDL-apoprotein labeling (apo B, C, E) necessitating tedious and error-prone separation procedures.
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References
M.W. Huff, N.H. Fidge, P.J. Nestel, T. Billington, and B. Wat-son, Metabolism of C-apolipoproteins: kinetics of C-II, C-IIIi and C - III 2, and VLDL-apolipoprotein B in normal and hyperlipoproteinemic subjects, J. Lipid Res., 22:1235 (1981).
M.W. Huff, and P.J. Nestel, Metabolism of apolipoproteins CII, CIIIi and CI II 2 and VLDL-B in human subjects consuming high carbohydrate diets, Metabolism, 31:493 (1982).
C.L. Malmendier, J-F. Lontie, G.A. Grutman, and C. Delcroix, Metabolism of apolipoprotein C-I in normolipoproteinemic human subjects, Atherosclerosis, 62:167 (1986)
C.L. Malmendier, J-F. Lontie, G. Grutman, and C. Delcroix, Metabolism of apolipoprotein C: kinetic studies in human subjects: a critical review, In: Lipoproteins and Atherosclerosis, C.L. Malmendier,and P. Alaupovic, eds, Plenum Press, New York (1986).
C.L. Malmendier, J-F. Lontie, G.A. Grutman, and G. Delcroix, Metabolism of apolipoprotein C-III in normolipemic human subjects, Atherosclerosis, 6 9:51 (1988).
M.L. Kashyap, L.S. Srivastava, B.A. Hynd, G. Perisutti, D.W. Brady, P. Gartside, and C.J. Glueck, The role of high density lipoprotein apolipoprotein CII in triglyceride metabolism, Lipids, 13:933 (1978).
J.L. Goldstein, W.R. Hazzard, H.G. Schrott, E.L. Bierman, and A.G. Motulsky, Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction, J. Clin. Invest., 52:1533 (1973).
J.L. Steinfeld, R.R. Paton, A.L. Flick, R.A. Milch, F.E. Beach, and D.L. Tabern, Distribution and degradation of human serum albumin labeled with I1 3 1 by different techniques, Ann. N.Y. Acad. Sci, 70: 109 (1957).
Lipid Research Clinics Program. Manual of Laboratory Operations. Lipid and Lipoprotein Analysis (DHEW Publication N° (NIH) 75-628), National Institutes of Health, Bethesda, MD, 1974.
W.T. Friedewald, R.I. Levy, and D.S. Fredrickson, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin. Chem., 18:499, (1972).
D.Y. Dubois, F. Cantraine, and C.L. Malmendier, Comparison of different sandwich enzyme immunoassays for the quantitation of human apolipoproteins A-I and A-II, J. Immunol. Methods, 96:115 (1987).
J-C. Fruchart, C. Fievet, and P. Puchois, Apolipoproteins, in : Methods of Enzymatic Analysis, Vol. VIII, H.U. Bergmeyer, ed., Verlag Chemie, Weinheim (1985).
J. Bury, G. Michiels, and M. Rosseneu, Human apolipoprotein C-II quantitation by sandwich enzyme-linked immunosorbent assay, J. Clin. Chem. Clin. Biochem., 24:457 (1986).
J. Bury, and M. Rosseneu, Enzyme linked immunosorbent assay for human apolipoprotein C-III, J. Clin. Chem. Clin. Biochem., 23:63 (1985).
Y.C. Ha, and P.J. Barter, Rapid separation of plasma lipoproteins by gel permeation chromatography on agarose gel Superose 6B, J. Chromatogr., 341:154 (1985).
C.M.E. Matthews, The theory of tracer experiments with iodine 131-labeled plasma proteins, Phys. Med. Biol., 2:36 (1957).
A. Rescigno, and E. Gurpide, Estimation of average times of residence, recycle and interconversion of blood-borne coumpounds using tracer methods, J. Clin. Endocrinol. Metab., 36:263 (1973).
C.L. Malmendier, and J-F. Lontie, Turnover studies of apolipoproteins C: a first critical appraisal, in: Proceed. 2nd Europ. Workshop on Lipid Metabolism, Munich (1988). Springer Verlag, Heidelberg, in press.
D.S. Fredrickson, J.L. Goldstein, and M.S. Brown, The familial hyperlipoproteinemias, chapter 30, in: The Metabolic Basis of Inherited Disease, J.B. Stanbury, J.B. Wyngaarden, and D.S. Fredrickson, eds., McGraw-Hill, New York (1978).
W.C. Breckenridge, J.A. Little, G. Steiner, A. Chow, and M. Poapst, Hypertriglyceridemia associated with deficiency of apolipoprotein C-II, N. Engl. J. Med., 298:1265 (1978).
W.C. Breckenridge, Apolipoprotein C-II deficiencies: in vivo models for assessing the significance of defective lipolysis on lipoprotein metabolism, in: Eicosanoids, Apolipoproteins, Lipoprotein Particles and Hypertriglyceridemia, C.L. Malmendier, and P. Alaupovic, eds., Plenum Press (1988). This volume.
L.A. Carlson, and D. Ballantyne, Changing relative proportions of apolipoproteins CII and CIII of very low density lipoproteins in hypertriglyceridaemia, Atherosclerosis, 23:563 (1976).
N.E. Miller, S.N. Rao, P. Alaupovic, N. Noble, J. Slack, J.D. Brunzell, and B. Lewis, Familial apolipoprotein CII deficiency: plasma lipoproteins and apolipoproteins in heterozygous and homozygous subjects and the effects of plasma infusion, Eur. J. Clin. Invest. 11:69 (1981).
W.V. Brown, and M.L. Baginsky, Inhibition of lipoprotein lipase by an apoprotein of human very low density lipopro tein, Biochem. Biophys. Res. Comm., 46:375 (1972).
E. Windier, and R.J. Havel, Inhibitory effects of C apolipoproteins from rats and humans on the uptake of tri glyceride-rich lipoproteins and their remnants by the perfused rat liver, J. Lipid. Res., 26:556 (1985).
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© 1988 Plenum Press, New York
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Malmendier, C.L., Lontie, JF., Dubois, D., Delcroix, C., Magot, T., De Roy, L. (1988). In Vivo Metabolism of Apolipoproteins C-II Aid C-IIII in Normal and Hypertriglyceridemic Subjects. In: Malmendier, C.L., Alaupovic, P. (eds) Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 243. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0733-4_38
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DOI: https://doi.org/10.1007/978-1-4613-0733-4_38
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