Abstract
Epidemiological studies have shown a relationship between low concentrations of high density lipoprotein (HDL) cholesterol and the incidence risk of cardiovascular diseases1,2. Recent pharmacological studies3 have clearl demonstrated the protective role of HDL in that respect. In the last decade much attention has been paid to the significance of apolipoprotein determination4,5. Thus, ApoAI, the major protein of HDL, appears to be a better predictor of coronary artery disease (CAD) than HDL cholesterol6,7. Two main types of lipoprotein particles are identified within HDL : those which contain ApoAI and ApoAII (LpAI:AII) and those which contain ApoAI but not ApoAII (LpAI). It has been shown quite recently that CAD subjects are characterized by a different distribution of ApoAI between LpAI and LpAI:AII, the data supporting the view that LpAI might represent the “antiatherogenic” fraction of HDL8.
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© 1988 Plenum Press, New York
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Barbaras, R., Puchois, P., Grimaldi, P., Barkia, A., Fruchart, J.C., Ailhaud, G. (1988). HDL Receptor and Reverse Cholesterol Transport in Adipose Cells. In: Malmendier, C.L., Alaupovic, P. (eds) Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 243. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0733-4_34
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DOI: https://doi.org/10.1007/978-1-4613-0733-4_34
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