Abstract
The role of low density (LDL) and high density (HDL) lipoproteins in cholesterol transport and the pathogenesis of coronary artery disease is widely known. Many studies have pointed out the importance of the physical chemical properties of these particles (1-2). In man, LDL from patients with familial hypercholesterolemia were larger and contained more cholesteryl esters and less triglycerides than the LDL from normal subjects (3,4,5). In animals, LDL from monkeys or swines fed an atherogenic diet were also large cholestery lester-enriched particles (6,7). Probucol is a lipid-lowering drug used in the management of hypercholesterolemia. The drug is transported primarily in lipoproteins, mostly LDL (8). Its mode of action remains unclear. Probucol treatment has been reported to decrease LDL and HDL cholesterol (9,10). The drug is effective in a high proportion of patients, including subjects with the heterozygous and homozygous forms of familial hypercholesterolemia (11,12) and in the receptor-deficient WHHL-rabbit (13). Kinetic studies of lipoprotein metabolism in animals (13) or in man (14,15) suggest that probucol might enhance LDL catabolism. This effect on the lipoprotein metabolism could be explained by a modification in lipoprotein composition and structure. This study is designed to investigate the effect of probucol treatment on the chemical composition and fluidity of LDL and HDL.
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References
A.R. Tall, D.M. Small, D. Atkinson, and J.L. Rudel, Studies on the structure of low density lipoproteins isolated from Macaca fascicularis fed anatherogenic diet, J. Clin. Invest. 62: 1354 (1978).
H.J. Pownall, R.L. Jackson, R.I. Roth, A.M. Gotto, J.R. Patsch, and F.A. Kummerow, Influence of an atherogenic diet on the structure of swine low density lipoproteins, J. Lipid Res. 21: 1108 (1980).
W. Patsch, R. Ostlund, I. Kuisk, R. Levy, and G. Schonfeld, Characterization of lipoprotein in a kind red with familial hypercholesterolemia, J. Lipid. Res. 23:1196 (1982).
A.V. Jardhav, and G.R. Thompson, Reversible abnormalities of low density lipoprotein composition in familial hypercholesterolemia, Europ. J. Clin. Invest. 9:63 (1979).
B. Teng, G.R. Thompson, A.D. Snidermann, T.M. Forte, R.M. Krauss, and P.O. Kwiterovich, Composition and distribution of low density lipoprotein fractions inhyper-alpha-lipoproteinemia, normolipidemia and familial hypercholesterolemia, Proc.Ntl.Acad.Sci.USA, 80:6662 (1988).
L.L. Rudel, M.G. Bond, and B.C. Bullock, LDL heterogeneity and atherosclerosis in non human primate, Ann.N.Y.Acad.Sci. 454:248 (1985).
A.R. Tall, D. Atkinson, D.M. Small, and R.W. Mahley, Characterisation of the lipoproteins of atherosclerotic swine, J. Biol. Chein. 252:7288 (1977).
C. Dachet, B. Jacotot, and J.C. Buxtorf, The hypolipidemic action of Probucol. Drug transport and lipoprotein composition in type Ila hyperlipoproteinemia, Atherosclerosis 58:261 (1985).
J. Lelorier, S. Dubreuil-Quidoz, S. Lussier-Cacan, Y.S. Huang and J. Davignon, Diet and Probucol in lowering cholesterol concentrations, Arch.Intern.Med. 137:1429 (1977).
M.J. Mellies, P.S. Gartside, L. Glatfelter, F. Vink, G. Guy, G. Schonfeld, and G.T. Glueck, Effect of probucol on plasma cholesterol, high and low density lipoprotein cholesterol and apoproteins A-I and A-II in adults with primary familial hypercholesterolemia, Metabolism 29:956 (1980).
S.G. Baker, B.I. Joffe, D. Mendelsohn, and H.C. Seftel, Treatment of homozygous familial hypercholesterolemia with probucol, S. Afr. Med. J. 62:7 (1982).
A. Yamamoto, Y. Matsuzawa, B. Kishino, R. Hayashi, K. Hirobe, and T. Kikkawa, Effects of Probucol on homozygous cases of familial hypercholesterolemia, Atherosclerosis 48:157 (1983).
M. Naruszewicz, T.E. Carew, R.C. Pittman, J.L. Witztum, and D. Steinberg, A novel mechanism by which J Probucol lowers low density lipoprotein levels demonstrated in the LDL receptor deficient rabbit, J. Lipid Res. 25:1206 (1984).
P.J. Nestel, and T. Billington, Effects of probucol on low density lipoprotein removal and high density lipoprotein synthesis, Atherosclerosis 38:203 (1981).
Y.A. Kesaniemi, and S.M. Grundy, Influence of probucol on cholesterol and lipoprotein metabolism in man, J. Lipid Res. 25:780 (1984).
L.L. Rudel, and L.L. Pitts, Male female variability in the dietary cholesterol induce dhyperlipoproteinemia of Cynomolgus monkeys (Macacafascicularis), J. Lipid Res. 19:992 (1978).
R.W. St.Clair, P. Greenspan and M.Leight, Enhanced cholesterol delivery to cells in culture by low density lipoproteins from hypercholesterolemic monkeys. Correlation of cellular cholesterol accumulation with low density lipoprotein molecular weight. Arteriosclerosis 3:77 (1983).
S. Eisenberg, High density lipoprotein metabolism, J. Lipid Res. 25:1017 (1984).
J. Ihm, D.M. Quinn, S.J. Busch, B.Chataing, and S.A.K. Harmony, Kinetics of plasma protein-catalyzed exchange of phosphatidylcholine and cholestery lester between plasma lipoproteins, J. Lipid Res. 23: 1328 (1982).
S. Parthasarathy, S.G. Young, J.L. Witztum, R.C. Pittman, and D. Steinberg, Probucol inhibits oxidative modification of low density lipoprotein, J. Clin. Invest. 77:641 (1985).
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© 1988 Plenum Press, New York
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Dachet, C., Motta, C., Neufcour, D., Jacotot, B. (1988). Modifications in the Chemical Composition and Thermometric Behavior of LDL and HDL by Probucol in Type IIa Hyperlipoproteinemia. In: Malmendier, C.L., Alaupovic, P. (eds) Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 243. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0733-4_22
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DOI: https://doi.org/10.1007/978-1-4613-0733-4_22
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