Abstract
Apolipoprotein B-100 (apoB-100) and apolipoprotein E (apoE) are the major protein constituents of human plasma low density lipoproteins (LDL), very low density lipoproteins (VLDL) and chylomicrons (1-4). Apofe-100 and apoE mediate the cellular uptake of these lipoproteins by binding to specific membrane receptors on hepatic and extrahepatic tissues. In addition, apoB-100 and apoE interact with sulfated mucopolysaccharides, e.g. glycosaminoglycans (GAG), of arterial tissue (5-10) and with heparin (11). The interaction of apoB-100 and apoE containing lipoproteins with GAG of the extracellular matrix may contribute to the accumulation of cholesterol in the arterial wall and, hence, promote atherosclerosis (12).
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© 1988 Plenum Press, New York
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Cardin, A.D., Jackson, R.L. (1988). Structural Properties of the Heparin-Binding Domains of Human Apolipoprotein E. In: Malmendier, C.L., Alaupovic, P. (eds) Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 243. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0733-4_19
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DOI: https://doi.org/10.1007/978-1-4613-0733-4_19
Publisher Name: Springer, Boston, MA
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