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Prostacyclin, EDRF and Atherosclerosis

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Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 243))

Abstract

The main metabolic product of the fatty acid arachidonic acid (AA) in vascular tissue is prostacyclin, a potent vasodilator and inhibitor of platelet aggregation (1). In contrast, in platelets AA is mainly converted to thromboxane A2, which is a potent vasoconstrictor and inducer of platelet aggregation. An imbalance in the formation or the interaction between these two AA metabolites has been implicated in the underlying process of various thrombotic conditions as well as of atherosclerosis (2).

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Authors and Affiliations

  1. The Wellcome Research Laboratories, Langley Court, Beckenham, Kent, BR3 3BS, UK

    Salvador Moncada

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  1. Salvador Moncada
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Editors and Affiliations

  1. Research Foundation on Atherosclerosis, Brussels, Belgium

    Claude L. Malmendier

  2. The Free University of Brussels, Brussels, Belgium

    Claude L. Malmendier

  3. Lipoprotein and Atherosclerosis Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

    Petar Alaupovic

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© 1988 Plenum Press, New York

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Moncada, S. (1988). Prostacyclin, EDRF and Atherosclerosis. In: Malmendier, C.L., Alaupovic, P. (eds) Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis. Advances in Experimental Medicine and Biology, vol 243. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0733-4_1

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  • DOI: https://doi.org/10.1007/978-1-4613-0733-4_1

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4613-0733-4

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