Abstract
A scanning ultrasound microscope has been constructed using a spherically focused Poly(Vinylidene fluoride) (PVDF) transducer. The system operates in the frequency range 50 MHz to 110 MHz (a consequence of the high bandwidth of PVDF) and has a corresponding lateral resolution limit of 17.5 µm. The system is designed to make two types of image: Attenuation images of thin specimens using a quartz flat as a reflector, and also dark field, backscatter images (C-scans) of cross-sectional planes within specimens up to 4 mm in diameter. A detailed analysis of the properties of PVDF over the frequency range 5 MHz to 170 MHz is presented and the design of a transducer which meets the bandwidth and sensitivity requirements for backscatter imaging is described. Axial resolution of 28 µm is demonstrated while signals from a viable multicell tumour spheroid showed a scatter signal to noise ratio of approximately 40 dB.
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References
Lemons, R.A. and Quate, C.F., Acoustic microscope - scannning version, Appl. Phys. Lett. 24: 163 (1974).
Lemons, R.A. and Quate, C.F., Advances in mechanically scanned acoustic microscopy, Ultrason. Symp. Proc. IEEE Cat. No. 74 CHO 896-ISU: 41 (1974).
Rugar, D., Heiserman, J., Minden, S. and Quate, C.F., Acoustic microscopy of human metaphase chromosomes, J. Microsc. 120: 193 (1980).
Foster, J.S. and Rugar, D., Low temperature acoustic microscopy, IEEE Trans. Sonics Ultrason. SU-32: 139 (1985).
Lin, Z., Lee, H., Wade, G. and Schueller, C.F., Computer-assisted tomographic acoustic microscopy for subsurface imaging, Acoustical Imaging, vol 13, ed. Kaveh, M., Mueller, R.K. and Greenleaf, J.F. ( New York: Plenum 1984 ) p. 91.
Jipson, V.B., Acoustic microscopy of interior planes, Appl. Phys. Lett. 35: 385 (1979).
Nikoonahad, M., Guangqi, Y. and Ash, E.A., Pulse compression acoustic microscopy using SAW filters, IEEE Trans. Sonics Ultrason. SU-32: 152 (1985).
Hill, C.R., Pulse echo imaging and measurement, in Physical Principles of Medical Ultrasonics ed. Hill, C.R. ( Ellis Horwood 1986 ) p. 278.
Broadhurst, M.G. and Davis, G.T., Piezo- and pyroelectric properties, in Electrets, Topics in Applied Physics, Vol 33 ( Springer-Verlag, Berlin, 1980 ) p. 285.
Krimholtz, R., Leedom, D.A. and Matthei, G.L., New equivalent circuits for elementary piezoelectric transducers, Electron. Lett (GB) 6: 338 (1970).
Sasabe, H., Saito, S., Asahina, M. and Kakutani, H., Dielectric relaxations in Poly(Vinylidene Fluoride), Journal of Polymer Science, Part A-2, 7: 1405 (1969).
Leung, W.P. and Yung, K.K., Internal losses in polyvinylidene fluoride (PVF2) ultrasonic transducers, J. Appl. Phys. 50: 8031 (1979).
Bui, L.N., Shaw, H.J. and Zitelli, L.T., Study of acoustic wave resonance in piezoelectric PVF2 film, IEEE Trans. Sonics Ultrason. SU-24(5):331 (1977).
Linvill, J.G., PVF2 models, measurements and devices, Ferroelectrics 28:291 (1980).
Hunt, J.W., Arditi, M. and Foster, F.S., Ultrasound transducers for pulse-echo medical imaging, IEEE Trans. Biomed. Eng. BME-30:453 (1983).
Sutherland, R.M., Carlsson, J., Durand, R. and Yuhas, J., Spheroids in cancer research, Cancer Res. 41:2980 (1981).
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© 1988 Plenum Press, New York
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Sherar, M.D., Foster, F.S. (1988). A 100 MHz Pvdf Ultrasound Microscope with Biological Applications. In: Kessler, L.W. (eds) Acoustical Imaging. Acoustical Imaging, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0725-9_47
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DOI: https://doi.org/10.1007/978-1-4613-0725-9_47
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