Interactions Between Proteins, Thiomolybdates and Copper
The concentration of copper (Cu) is elevated in the kidneys of sheep1 fed diets containing high levels of molybdenum (Mo) and sulfur (S) or given supplements of tetrathiomolybdate (TTM). A similar effect occurs in liver and kidney when TTM is administered to rats.2 In both species these elevated Cu concentrations may occur together with signs of Cu deficiency such as decreased activity of Cu-dependent enzymes. The accumulated Cu elutes in the high molecular weight range (>100,000 MW) on Sephadex G-75, and is usually accompanied by Mo. It apparently accumulates in forms that do not readily equilibrate with the pools of metabolically available Cu.
KeywordsSulfhydryl Group Chromatographic Profile Molybdenum Compound Sheep Liver Elution Position