Interactions Between Proteins, Thiomolybdates and Copper

  • J. D. Allen
  • J. M. Gawthorne


The concentration of copper (Cu) is elevated in the kidneys of sheep1 fed diets containing high levels of molybdenum (Mo) and sulfur (S) or given supplements of tetrathiomolybdate (TTM). A similar effect occurs in liver and kidney when TTM is administered to rats.2 In both species these elevated Cu concentrations may occur together with signs of Cu deficiency such as decreased activity of Cu-dependent enzymes. The accumulated Cu elutes in the high molecular weight range (>100,000 MW) on Sephadex G-75, and is usually accompanied by Mo. It apparently accumulates in forms that do not readily equilibrate with the pools of metabolically available Cu.


Sulfhydryl Group Chromatographic Profile Molybdenum Compound Sheep Liver Elution Position 
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  1. 1.
    J. D. Alien and J. M. Gawthorne, Involvement of Organic Molybdenum compounds in the interaction between Copper, Molybdenum and Sulfur, J. Inorg. Biochem., 27: 95 (1986).CrossRefGoogle Scholar
  2. 2.
    C. F. Mills, T. T. El-Gallad and I. Bremner, Effects of molybdate, sulphide and tetrathiomolybdate on copper metabolism in rats, J. Inorg. Biochem., 14: 189 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. D. Allen
    • 1
  • J. M. Gawthorne
    • 1
  1. 1.School of Veterinary StudiesMurdoch UniversityMurdochAustralia

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