Enhanced Maternal Transfer of Fluoride in the Magnesium-Deficient Rat

  • Florian L. Cerklewski
  • James W. Ridlington


Although placental and mammary tissue have been shown to be formidable barriers to fluoride,1 there is some evidence to suggest that even small amounts of transferred fluoride have significance for health of developing offspring.2 In the present study our intent was to determine if the maternal barrier to fluoride could be influenced by nutritional status. We chose magnesium as a factor based upon our previous findings of a strong relationship between magnesium and fluoride in weanling rats.3


Zinc Magnesium Depression Fluoride Fluorine 


  1. 1.
    E.J. Underwood, Fluorine, in: “Trace Elements in Human and Animal Nutrition,” 4th edition, p. 347, Academic Press, NY.Google Scholar
  2. 2.
    F.B. Glenn, W.D. Glenn III, and R.C. Duncan, Fluoride tablet supplementation during pregnancy for caries immunity; a study of the offspring produced, Am. J. Obstet. Gynecol. 143: 560 (1982).PubMedGoogle Scholar
  3. 3.
    F.L. Cerklewski, Influence of dietary magnesium on fluoride bio-availability in the rat, J. Nutr. 117: 496 (1987).PubMedGoogle Scholar
  4. 4.
    F.L. Cerklewski and J. W. Ridlington, Influence of zinc and iron on dietary fluoride utilization in the rat, J. Nutr. 115: 1162 (1985).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Florian L. Cerklewski
    • 1
  • James W. Ridlington
    • 1
  1. 1.Department of Foods and NutritionOregon State UniversityCorvallisUSA

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