Copper Tolerance in Rats — A Histochemical and Immunocytochemical Study

  • M. Elmes
  • S. Haywood
  • J. P. Clarkson
  • I. C. Fuentealba
  • B. Jasani

Abstract

Metallothionein (MT) has been associated with the detoxification of heavy metals (1) and it is possible that the acquired tolerance of rats (2) is related to the induction of MT synthesis.

Keywords

Spectrophotometry Rhodanine 

References

  1. 1.
    Bremner I (1981) The Nature and Function of Metallo-thionein in Trace Element Metabolism in Man and Animals. TEMA-4. Ed. J. Mcc Howell, J.M. Gawthorne & C.L. White. Aus. Acad. Science, Canberra, 1981.Google Scholar
  2. 2.
    Haywood S (1985) Copper Toxicosis and Tolerance in the Rat I Changes in Copper Content of Liver and Kidney. J. Path. 145: 149–158.PubMedCrossRefGoogle Scholar
  3. 3.
    Clarkson J P, Elmes M E, Jasani B; Webb M (1985) Histological Demonstration of Immunoreactive Zn Metallothionein in Liver, Ileum of Rat and Man. Histochem. J. 17: 343–352.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • M. Elmes
    • 1
  • S. Haywood
    • 2
  • J. P. Clarkson
    • 1
  • I. C. Fuentealba
    • 2
  • B. Jasani
    • 1
  1. 1.Department of PathologyThe University of Wales College of MedicineCardiffUK
  2. 2.Department of Veterinary PathologyUniversity of LiverpoolLiverpoolUK

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