Marginal Zn Deficiency Affects Pup Brain Microtubule Assembly in Rats
Zinc has been shown to bind to tubulin (Hesketh, 1983; Eagle et al., 1983) and to have a stimulatory effect on tubulin assembly in vitro (Haskins et al., 1980; Hesketh, 1982). There is evidence which supports a physiological role of Zn on microtubule (Mct) formation. High concentrations of Zn have been found to be associated with Mct obtained from sea urchin spermatozoa and in the mitotic apparatus from sea urchin eggs (Morisawa & Mohri, 1972). Hesketh (1981) has reported that tubulin polymerization in brain supernatants from severely Zn deficient (< 1 ug Zn/g diet) pigs and rats was slower than in controls.