Genetic and Biochemical Analysis of Copper Transport in Escherichia coli

  • D. Rouch
  • J. Camakaris
  • G. Adcock
  • B. T. O. Lee

Abstract

Copper is an essential trace element yet it is also potentially toxic. Complex cellular Cu management systems should exist to ensure that supply of Cu to Cu-dependent enzymes occurs without associated toxicity. We predict that these Cu management systems should include: (i) uptake, (ii) intracellular transport and storage, (iii) repair and nullification of Cu damage, (iv) efflux, (v) regulation of cellular Cu levels. Our aim is to use a genetic approach in the microorganism Escherichia coli to investigate these systems. The findings in E. coli will provide leads for research in mammalian systems.

Keywords

Toxicity Polypeptide Copper Sulphate 

References

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • D. Rouch
    • 1
  • J. Camakaris
    • 2
  • G. Adcock
    • 2
  • B. T. O. Lee
    • 2
  1. 1.Department of MicrobiologyMonash UniversityClaytonAustralia
  2. 2.Department of GeneticsUniversity of MelbourneParkvilleAustralia

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