Abstract
The induction of metallothionein (MT) by copper has historically been a controversial area of research. Initial work in the mid 1970’s suggested that parenteral copper caused induction of a cysteine-rich protein (copper chelatin) distinct from MT. However, this protein is now considered to be an artifact.1
Keywords
- Anion Exchange Chromatography
- Controversial Area
- Copper Supplementation
- Hepatic Copper
- Parenteral Copper
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
I. Bremner, Involvement of metallothionein in the hepatic metabolism of copper. J. Nutr. 117: 19–29 (1987)
D.M. Durnam and R.D. Palmiter, Transcriptional regulation of the mouse metallothionein-I gene by heavy metals. J.Biol.Chem. 256: 5712–5716 (1981)
I. Bremner, R.K. Mehra, J.N. Morrison and A.M. Wood, Effects of dietary copper supplementation of rats on the occurrence of metallothionein-I in liver and its secretion into blood, bile and urine. Biochem. J. 235: 735–739 (1986)
K.B. Nielson, C.L. Atkin and D.R. Winge, Distinct metal-binding configurations in metallothionein. J. Biol. Chem. 260: 5342–5350 (1985)
K.B. Nielson and D.R. Winge, Preferential binding of copper to the beta domain of metallothionein. J. Biol. Chem. 259: 4941–4946 (1984)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
McCormick, C.C., Lin, LY. (1988). Accumulation of Hepatic Zn7 and Zn/Cu Metallothionein in Copper-Loaded Chicks: Isolation and Characterization. In: Hurley, L.S., Keen, C.L., Lönnerdal, B., Rucker, R.B. (eds) Trace Elements in Man and Animals 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0723-5_13
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0723-5_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8050-7
Online ISBN: 978-1-4613-0723-5
eBook Packages: Springer Book Archive