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Role of the Natural Immune System in the Antibody Response

Regulatory Effect of NK Cells

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Functions of the Natural Immune System

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Abstract

Natural killer (NK) cells were originally described as effector cells capable of in vitro lysis of certain tumor targets.(1) However, concurrent with the revelation of NK cell antitumor potential, it became evident that these cells are also involved in the regulation of the growth and differentiation of hematopoietic systems.(2) This was initially demonstrated by the evidence that histoincompatible bone marrow cells would grow in the NK cell-depleted, NK cell-deficient, or NK cell—immature mice but not in the NK cell-stimulated mice.(3,4) Later, the direct involvement of NK cells in murine bone marrow transplantation was demonstrated by abrogation of resistance to parental and allogeneic bone marrow grafts in mice depleted of NK cells by NK 1.1 monocloned antibody and by restoration of bone marrow graft resistance in NK cell-depleted mice by transfer of cloned NK cells.(5)

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Authors and Affiliations

  1. Department of Microbiology, Tohoku University School of Dentistry, Sendai, Japan

    Katsuo Kumagai, Satsuki Suzuki & Ryuji Suzuki

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  1. Katsuo Kumagai
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  2. Satsuki Suzuki
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  3. Ryuji Suzuki
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  1. Frederick Cancer Research Facility, National Cancer Institute, Frederick, Maryland, USA

    Robert H. Wiltrout

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© 1989 Plenum Press, New York

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Kumagai, K., Suzuki, S., Suzuki, R. (1989). Role of the Natural Immune System in the Antibody Response. In: Reynolds, C.W., Wiltrout, R.H. (eds) Functions of the Natural Immune System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0715-0_9

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  • DOI: https://doi.org/10.1007/978-1-4613-0715-0_9

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