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Involvement of Natural Effector Cells in Graft versus Host Disease

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Functions of the Natural Immune System
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Abstract

Graft versus host disease (GVHD) is the consequence of transplanting a graft of immunocompetent allogeneic lymphoid cells into a host unable to reject them.(1) Many of the clinical studies on GVHD have resulted after bone marrow transplantation to patients with leukemia, aplastic anemia, or immunodeficiency.(2,3)

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References

  1. Billingham, R. E., Defendi, V., Silvers, W. K., and Steinmuller, D., 1962, Quantitative studies on the induction of tolerance of skin homografts and on runt disease in neonatal rats, JNCI 28:365–435.

    PubMed  CAS  Google Scholar 

  2. Santos, G. W., Hess, A. D., and Vogelsang, G. B., 1985, Graft-versus-host reactions and disease, Immunol. Rev. 88:169–192.

    Article  PubMed  CAS  Google Scholar 

  3. Storb, R., and Thomas, E. D., 1985, Graft-versus-host disease in dog and man: The Seattle experience, Immunol. Rev.88: 215–238.

    Article  PubMed  CAS  Google Scholar 

  4. Korngold, R., and Sprent, J., 1985, Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differences, J Immunol. 135:3004–3010.

    PubMed  CAS  Google Scholar 

  5. Piquet, P. F., 1985 GVHR elicited by products of class I or class II loci of the MHC: Analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GVHR-induced mortality, medullary aplasia, and enteropathy, J. Immunol. 135:1637–1643.

    Google Scholar 

  6. Clancy, J. Jr., and Mauser, L., 1981, The absolute level of IgG Fi and C3 receptor-positive T, B, and null leukocytes within various lymphoid compartments during acute graft-versus-host disease in the adult rat, Transplantation 32:401–408.

    Article  PubMed  Google Scholar 

  7. Stuart, S. P., Klein, R. M., and Clancy, J. Jr., 1987, Kinetics of mast cell, fibroblast, and epidermal cell poliferation during acute graft-versus-host disease in the neonatal rat, J. Invest. Dermatol 88:369–374.

    CAS  Google Scholar 

  8. Klein, R. M., Clancy, J., and Stuart, S., 1982, Acute lethal graft-versus-host disease stimulates cellular proliferation in the adult rat liver, Cell Tissue Kinet. 15:651–660.

    PubMed  CAS  Google Scholar 

  9. Clancy, J. Jr., Klein, R. M., and Weddle, S. L., 1981, Stimulation of cellular proliferation in the adult rat submandibular gland during acute graft-versus-host disease, Transplantation 31:296–299.

    Article  PubMed  Google Scholar 

  10. Champlin, R. E., and Gale, R. P., 1984, Role of bone marrow transplantation in the treatment of hematologic malignancies and solid tumors: Critical review of syngeneic, antologous, and allogeneic transplants, Cancer Treat. Rep. 68:145–161.

    PubMed  CAS  Google Scholar 

  11. O’Reilly, R. J., 1983, Allogeneic bone marrow transplantation: Current status and future directions, Blood 62:941–964.

    PubMed  Google Scholar 

  12. Sullivan, K. M., Shulman, H. M., Storb, R., Weiden, P. L., Witherspoon, R. P., Schubert, M. M., Atkinson, K., and Thomas, E. D., 1981, Chronic graft-versus-host disease in 52 patients: Adverse natural course and successful treatment with combination immunosuppression, Blood 57:267–276.

    PubMed  CAS  Google Scholar 

  13. Tsoi, M.-S., Storb, R., Dobbs, S., Medill, L., and Thomas, E. D., 1980, Cell mediated immunity to non-HLA antigens of the host by donor lymphocytes in patients with chronic graft-versus-host disease, J. Immunol. 125:2258–2262.

    PubMed  CAS  Google Scholar 

  14. Maier, T., Holda, J. H., and Claman, H. N., 1985, Graft-vs-host reactions (GVHR) across minor murine histocompatibility barriers. II. Development of natural suppressor cell activity, J. Immunol. 135:1644–1651.

    PubMed  CAS  Google Scholar 

  15. Streilein, J. W., 1972, Pathologic lesions of GVH disease in hamsters: Antigenic target versus “innocent bystanders,” Prog. Exp. Tumor Res. 16:396—408.

    PubMed  CAS  Google Scholar 

  16. Lopez, C., Kirkpatrick, D., Sorell, M., and O’Reilly, R. J., 1979, Association between pretransplant natural killer and graft-versus-host disease after stem cell transplantation, Lancet 2:1103–1107.

    Article  PubMed  CAS  Google Scholar 

  17. Lotzova, E., and Cudkowicz, G., 1973, Assistance of irradiated Fl hybrid and allogeneic mice to bone marrow grafts of NZB donors, J. Immunol. 110:791–800.

    PubMed  CAS  Google Scholar 

  18. Bortin, M. M., Truitt, R. L., Rimm, A. A., and Bach, F. H., 1979, Graft versus leukemia reactivity induced by alloimmunization without augmentation of graft versus host reactivity, Nature 281:490–491.

    Article  PubMed  CAS  Google Scholar 

  19. Lotzova, E., Savary, C. A., and Herberman, R. B., 1987, Induction of NK cell activity against fresh human leukemia in culture with interleukin 2, J. Immunol. 138:2718–2727.

    PubMed  CAS  Google Scholar 

  20. Livnat, S., Seigneuret, M., Storb, R., and Prentice, R. L., 1980, Analysis of cytotoxic effector cell function in patients with leukemia or aplastic anemia before and after marrow transplantation, J. Immunol. 124:481–490.

    PubMed  CAS  Google Scholar 

  21. Mizuno, S., Morishima, Y., Kodera, Y., Ohno, R., Yokomaku, S., Sao, H., and Yoshikawa, S., 1986, Gamma-interferon production capacity and T lymphocyte subpopula tion after allogeneic bone marrow transplantation. Transplantation 41:311–315.

    Article  PubMed  CAS  Google Scholar 

  22. Rooney, C. M., Wimperis, J. Z., Brenner, M. K., Patterson, B. J., Hoffbrand, A. V., and Prentice, H. G., 1986, Natural killer cell activity following T-cell depleted allogeneic bone marrow transplantation, Br. J. Haematol. 62:413–420.

    Article  PubMed  CAS  Google Scholar 

  23. DeVillartay, J. P., LeDeist, F., Griscelli, C., and Fischer, A., 1987, Dissociation between onset of natural killer E-rosette forming cells and of T3-positive cells following HLA-mismatched T cell depleted bone marrow transplantation, Clin. Exp. Immunol. 67:406– 414.

    CAS  Google Scholar 

  24. Parreira, A., Smith, J., Hows, J. M., Smithers, S. A., Apperley, J., Rombos, Y., Gordon-Smith, E. C. and Catovsky, D., 1987, Immunological reconstitution after bone marrow transplant with Campath-1 treated bone marrow, Clin. Exp. Immunol. 67:142–150.

    PubMed  CAS  Google Scholar 

  25. Anderson, K. C., Ritz, J., Takvorian, T., Coral, F., Daley, H., Canellos, G. P., Schlossman, S. F., and Nadler, L. M., 1987, Hematologic engraftment and immune reconstitution posttransplantation with anti-B 1 purged autologous bone marrow, Blood 69:597–604.

    PubMed  CAS  Google Scholar 

  26. Pattengale, P. K., Ramstedt, U., Gidlund, M., Orn, A., Axberg, I., and Wigzell, H., 1983, Natural killer activity in (C57BL/6 x DAB/2)F1 hybrids undergoing acute and chronic graft-vs.-host reaction, Eur. J. Immunol. 13:912–919.

    Article  PubMed  CAS  Google Scholar 

  27. Varkila, K., and Hurme, M., 1985, Natural killer (NK) cells and graft-versus-host disease (GVHD): No correlation between the NK cell levels and GVHD in the murine P-F1 model, Immunology 54:121–126.

    PubMed  CAS  Google Scholar 

  28. Ford, W. L., Burr, W., and Simonsen, M., 1970, A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells. Transplantation 10:258–266.

    Article  PubMed  CAS  Google Scholar 

  29. Brideau, R. J., Carter, P. B., McMaster, W. R., Mason, D. W., and Williams, A. F., 1980, Two subsets of rat T lymphocytes defined with monoclonal antibodies, Eur. J. Immunol. 10:609–615.

    Article  PubMed  CAS  Google Scholar 

  30. Rolstad, B., Fossum, S., Hunt, S. V., and Ford, W. L., 1986, The host component of the popliteal lymph node graft-versus-host reaction. Selective representation of lymphocyte subsets and the requirement of alloantigenic incompatibility between donor cells and activated host B cells, Scand. J. Immunol. 23:589–598.

    Article  PubMed  CAS  Google Scholar 

  31. Reynolds, C. W., Timonen, T., and Herberman, R. B., 1981, Natural killer (NK) cell activity in the rat. I. Isolation and characterization of the effector cells, J. Immunol. 127:282–287.

    PubMed  CAS  Google Scholar 

  32. Dokhelar, M.-C., Wiels, J., Lipinski, M., Tetaud, C., Devergie, A., Gluckman, E., and Tursz, T., 1981, Natural killer cell activity in human bone marrow recipients. Early reappearance of peripheral natural killer activity in graft-versus-host disease, Transplantation 31:61–65.

    Article  PubMed  CAS  Google Scholar 

  33. Gratama, J. W., Lipovich-Oosterveer, M. A., Ronteltap, C., Sinnige, L. G. F., Van der Griend, R. J., and Bolhuis, R. L. H., 1985, Natural immunity and graft-versus-host disease, Transplantation 40:256–260.

    Article  PubMed  CAS  Google Scholar 

  34. Favrot, M., Janossy, G., Tidman, N., Blacklock, H., Lopez, E., Bofill, M., Lambert, I., and Morgenstein, G., 1983, T cell regeneration after allogeneic bone marrow transplantation, Clin. Exp. Immunol. 54:59–72.

    PubMed  CAS  Google Scholar 

  35. Janossy, G., Prentice, H. G., Grob, J.-P., Ivory, K., Tidman, N., Grundy, J., Griffiths, P. D., and Hoffbrand, A. V., 1986, T lymphocyte regeneration after transplantation of T cell depleted allogeneic bone marrow, Clin. Exp. Immunol. 63:577–586.

    PubMed  CAS  Google Scholar 

  36. Lum, L. G., Seigneuret, M. C., Storb, R. F., Witherspoon, R. P., and Thomas, E. D., 1981, In vitroregulation of immunoglobulin synthesis after marrow transplantation. I. T-cell and B-cell deficiencies in patient with and without graft-versus-host disease, Blood 58:431–438.

    CAS  Google Scholar 

  37. Dosch, H. M., and Gelfand, E. W., 1981, Failure of T and B cell cooperation during graft-versus-host disease, Transplantation 31:48–50.

    Article  PubMed  CAS  Google Scholar 

  38. Matsue, K., Lum, L. G., Witherspoon, R. P., and Storb, R., 1987, Proliferative and differentiative response of B cells from human marrow graft recipients to T cell-derived factors, Blood 69:308–315.

    PubMed  CAS  Google Scholar 

  39. Brenner, M. K., Reittie, J. E., Grob, J.-P., Wimperis, J. Z., Stephens, S., Patterson, J., Hoffbrand, A. V., and Prentice, H. G., 1986, The contribution of large granular lymphocytes to B cell activation and differentation after T-cell-depleted allogeneic bone marrow transplantation, Transplantation 42:257–261.

    Article  PubMed  CAS  Google Scholar 

  40. Brenner, M. K., Vyakarnam, A., Reittie, J. E., Wimperis, J. Z., Grob, J. P., Hoffbrand, A. V., and Prentice, H. G., 1987, Human large granular lymphocytes induce immunoglobulin synthesis after bone marrow transplantation, Eur. J. Immunol. 17:43–47.

    Article  PubMed  CAS  Google Scholar 

  41. Weiden, P. L., Flournoy, N., Thomas, E. D., Prentice, R., Fefer, A., Buckner, C. D., and Storb, R., 1979, Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts, N. Engl. J. Med. 300:1068–1073.

    Article  PubMed  CAS  Google Scholar 

  42. Hercend, T., Takvorian, T., Nowill, A., Tantravahi, R., Moingeon, P., Anderson, K. C., Ytheir, A., and Ritz, J., 1986, Characterization of natural killer cells with antileukemia activity following allogeneic bone marrow transplantation, Blood 67:722–728.

    PubMed  CAS  Google Scholar 

  43. Slavin, R., and Santos, G., 1973, The graft versus host reaction in man after bone marrow transplantation: Pathology, pathogenesis, clinical features, and implication, Clin. Immunol. Immunopathol. 1:472–498.

    Article  PubMed  CAS  Google Scholar 

  44. Bernnan, D., Gisselbrecht, C., Devergie, A., Feldman, G., Gluckman, E., Martz, M., and Bviron, M., 1980, Histological and ultrastructural appearance of the liver during graft-versus-host disease complicating bone marrow transplantation, Transplantation 29:236–244.

    Article  Google Scholar 

  45. Dilly, S. A., and Sloane, J. R., 1985, An immunohistological study of human hepatic graft-versus-host disease, Clin. Exp. Immunol. 62:545–553.

    PubMed  CAS  Google Scholar 

  46. Sloane, J. P., Thomas, J. A., Imrie, S. F., Easton, D. F., and Powles, R. L., 1984, Morphological and immunohistological changes in the skin in allogeneic bone marrow recipients, J. Clin. Pathol. 37:919–930.

    Article  PubMed  CAS  Google Scholar 

  47. Dilly, S. A., and Sloane, J. P., 1987, Changes in rectal leukocytes after allogeneic bone marrow transplantation, Clin. Exp. Immunol. 67:151–158.

    PubMed  CAS  Google Scholar 

  48. Roy, C., Ghayur, T., Kongshavn, P. A. L., and Lapp, W. S., 1982, Natural killer activity by spleen, lymph node, and thymus cells during graft-versus-host reaction, Transplantation 34:144–146.

    Article  PubMed  CAS  Google Scholar 

  49. Ghayur, T., Seemayer, T. A., and Lapp, W. S., 1987, Kinetics of natural killer (NK) cell cytotoxicity during the graft-versus-host reaction. Relationship between NK cell activity, T and B activity, and development of histopathological alterations, Transplantation 44:254–260.

    Article  PubMed  CAS  Google Scholar 

  50. Ghayur, T., Seemayer, T. A., and Lapp, W. S., 1988, Prevention of marine graft-versus-host disease by inducing and eliminating ASGM1+ cells of donor origin, Transplantation 45:586–590.

    Article  PubMed  CAS  Google Scholar 

  51. Ghayur, T., Seemayer, T. A., Kongshavn, P. A. L., Gartner, J. G., and Lapp, W. S., 1987, Graft-versus-host (GVH) reactions in the beige mouse: An investigation of the role of host and donor natural killer (NK) cells in the pathogenesis of GVH disease, Transplantation 44:261–267.

    Article  PubMed  CAS  Google Scholar 

  52. Borland, A., Mowat, A. I., and Parrott, D. M. V., 1983, Augmentation of intestinal and peripheral natural killer cell activity during graft-versus-host reaction in mice, Transplantation 36:513–519.

    Article  PubMed  CAS  Google Scholar 

  53. Guy-Grand, D., Griscelli, C., and Vassalli, P., 1978, The moust gut T lymphocyte, a novel type of T cell, J. Exp. Med. 148:1661–1677.

    Article  PubMed  CAS  Google Scholar 

  54. Mowat, A., 1986, Evidence that Ia+ bone-marrow-derived cells are stimulus for the intestinal phase of the murine graft-versus-host reaction, Transplantation 42:141–144.

    Article  PubMed  CAS  Google Scholar 

  55. Charley, M. R., Mikhael, A., Bennett, M., Gilliam, J. N., and Sontheimer, R. D., 1983, Prevention of lethal, minor-determinate graft-versus-host disease in mice by the in vivo administration of anti—asialo GMI, J. Immunol. 131:2101–2103.

    PubMed  CAS  Google Scholar 

  56. Charley, M. R., Mikhael, A., Hoot, G., Hackett, J., and Bennett, M., 1985, Studies addressing the mechanism of anti—asialo GM1 prevention of graft-versus-host disease due to minor histocompatibility antigenic differences,J. Invest. Dermatol. 85:121S–123S.

    Article  PubMed  CAS  Google Scholar 

  57. Ting, C.-C., Bluestone, J. A., Hargrove, M. E., and Loh, N.-N., 1986, Expression and function of asialo GM1 in alloreactive cytotoxic T lymphocytes, J. Immunol. 137:2100–2106.

    PubMed  CAS  Google Scholar 

  58. Thiele, D. L., Charley, M. R., Calomeni, J. A., and Lipsky, P. E., 1987, Lethal graft-versus-host disease across major histocompatibility barriers: requirement for leucyl-leucine methyl ester sensitive cytotoxic T cells. J. Immunol. 138:51–57.

    PubMed  CAS  Google Scholar 

  59. Guillen, R. J., Ferrara, J., Hancock, W. W., Messadi, D., Fonferko, E., Burakoff, S. J., and Murphy, G. F., 1986, Acute cutaneous graft-versus-host disease to minor histocompatibility antigens in murine model, Lab. Invest. 55:35–42.

    PubMed  CAS  Google Scholar 

  60. Romani, N., Stingl, G., Tschachler, E., Witmer, M. D., Steinman, R. M., Shevch, E. M., and Schuler, G., 1985, The Thy-1-bearing cell of murine epidermis. A distinctive leukocyte perhaps related to natural killer cells, J. Exp. Med. 161:1368–1383.

    Article  PubMed  CAS  Google Scholar 

  61. Clancy, J. Jr., Mauser, L., and Chapman, A. L., 1983, Level and temporal pattern of naturally cytolytic cells during acute graft-versus-host disease (GVHD) in the rat, Cell. Immunol. 79:1–10.

    Article  PubMed  Google Scholar 

  62. Renkonen, R., and Hayry, P., 1984, Bone marrow transplantation in the rat. I. Histologic correlations and quantitation of cellular infiltrates in acute graft-versus-host disease, Am. J. Pathol. 117:462–470.

    PubMed  CAS  Google Scholar 

  63. Stet, R. J. M., Thomas, C., Koudstaal, J., Hardonk, M. J., Hulstaert, C. E., and Nieuwenhuis, P., 1986, Graft-versus-host disease in the rat: Cellular changes and major histocompatibility complex antigen expression in the liver, Scand.J. Immunol. 23:81–89.

    Article  PubMed  CAS  Google Scholar 

  64. Wisse, E., Van’t Noordende, J. M., Van der Menlen, J., and Deams, W. T., 1976, The pit cell: Description of a new cell occurring in rat liver sinusoids and peripheral blood, Cell Tissue Res. 173:423–435.

    Article  PubMed  CAS  Google Scholar 

  65. Rolstad, B., Fossum, S., Bazin, H., Kimber, I., Marshall, J., Sparshott, S. M., and Ford, W. L., 1985, The rapid rejection of allogeneic lymphocytes by a non-adaptive, cell-me-diated mechanism (NK activity), Immunology 54:127–138.

    PubMed  CAS  Google Scholar 

  66. Kasahara, T., Djeu, J. Y., Dougherty, S. F., and Oppenheim, J. J., 1983, Capacity of human large granular lymphocytes (LGL) to produce multiple lymphokines: Interleukin 2, interferon, and colony stimulating factor, J. Immunol. 131:2379–2385.

    PubMed  CAS  Google Scholar 

  67. Grimm, E. A., Mazumder, A., Zhang, H. Z., and Rosenberg, S. A., 1982, Lymphokine-activated killer cell phenomenon. Lysis of natural killer—resistant fresh solid tumor cells by interleukin 2—activated antologous human peripheral blood lymphocytes, J. Exp. Med. 155:1823–1841.

    Article  PubMed  CAS  Google Scholar 

  68. Mori, T., Tsoi, M.-S., Gillis, S., Santos, E., Thomas, E. D., and Storb, R., 1983, Cellular interactions in marrow-grafted patients. I. Impairment of cell-mediated lympholysis associated with graft-vs-host disease and the effect of interleukin 2, J. Immunol. 130:712–716.

    PubMed  CAS  Google Scholar 

  69. Merluzzi, V. J., Welte, K., Last-Barney, K., Mertelsmann, R., Souza, L., Savage, D. M., Quinn, D., and O’Reilly, R. J., 1985, Production and response to interleukin 2 in vitroand in vivoafter bone marrow transplantation in mice, J. Immunol. 134:2426–2430.

    PubMed  CAS  Google Scholar 

  70. Malkovsky, M., Brenner, M. K., Hunt, R., Rastan, S., Dore, C., Asherson, G. L., Prentice, H. G., and Medawar, P. B., 1986, T-cell depletion of allogeneic bone marrow prevents acceleration of graft-versus-host disease induced by exogenous interleukin 2, Cell Immunol. 103:476–480.

    Article  PubMed  CAS  Google Scholar 

  71. Clancy, J. Jr., Goral, J., Triner, J., and Ellis, T., 1987, Increased activation of YAC-1 killer (natural killers: NK) versus Daudi killers (lymphokine activated killers: LAK) by spleen cells from control and acute graft versus host disease (AGVHD) rats by recombinant IL-2 (Ril-2), Anat. Rec. 218:25A.

    Google Scholar 

  72. Volk, H.-D., Brocke, S., Osawa, H., and Diamantstein, T., 1986, Suppression of the local graft-vs.-host reaction in rats by treatment with a monoclonal antibody specific for the interleukin 2 receptor, Eur. J. Immunol. 16:1309–1312.

    Article  PubMed  CAS  Google Scholar 

  73. Diamanstein, T., Volk, H.-D., Tilney, N. L., and Kupiec-Weglinski, J., 1986, Specific immunosuppressive therapy by monoclonal anti-IL-2 receptor antibody and its synergistic action with cyclosporin, Immunobiology 172:391–399.

    Google Scholar 

  74. Ferrara, J. L. M., Marion, A., Mclntyre, J. F., Murphy, G. F., and Burakoff, S. J., 1986, Amelioration of acute graft vs host disease due to minor histocompatibility antigens by in vivo administration of anti-interleukin 2 receptor antibody, J. Immunol. 137:1874–1877.

    PubMed  CAS  Google Scholar 

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Clancy, J. (1989). Involvement of Natural Effector Cells in Graft versus Host Disease. In: Reynolds, C.W., Wiltrout, R.H. (eds) Functions of the Natural Immune System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0715-0_16

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  • DOI: https://doi.org/10.1007/978-1-4613-0715-0_16

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