Abstract
Graft versus host disease (GVHD) is the consequence of transplanting a graft of immunocompetent allogeneic lymphoid cells into a host unable to reject them.(1) Many of the clinical studies on GVHD have resulted after bone marrow transplantation to patients with leukemia, aplastic anemia, or immunodeficiency.(2,3)
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Billingham, R. E., Defendi, V., Silvers, W. K., and Steinmuller, D., 1962, Quantitative studies on the induction of tolerance of skin homografts and on runt disease in neonatal rats, JNCI 28:365–435.
Santos, G. W., Hess, A. D., and Vogelsang, G. B., 1985, Graft-versus-host reactions and disease, Immunol. Rev. 88:169–192.
Storb, R., and Thomas, E. D., 1985, Graft-versus-host disease in dog and man: The Seattle experience, Immunol. Rev.88: 215–238.
Korngold, R., and Sprent, J., 1985, Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differences, J Immunol. 135:3004–3010.
Piquet, P. F., 1985 GVHR elicited by products of class I or class II loci of the MHC: Analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GVHR-induced mortality, medullary aplasia, and enteropathy, J. Immunol. 135:1637–1643.
Clancy, J. Jr., and Mauser, L., 1981, The absolute level of IgG Fi and C3 receptor-positive T, B, and null leukocytes within various lymphoid compartments during acute graft-versus-host disease in the adult rat, Transplantation 32:401–408.
Stuart, S. P., Klein, R. M., and Clancy, J. Jr., 1987, Kinetics of mast cell, fibroblast, and epidermal cell poliferation during acute graft-versus-host disease in the neonatal rat, J. Invest. Dermatol 88:369–374.
Klein, R. M., Clancy, J., and Stuart, S., 1982, Acute lethal graft-versus-host disease stimulates cellular proliferation in the adult rat liver, Cell Tissue Kinet. 15:651–660.
Clancy, J. Jr., Klein, R. M., and Weddle, S. L., 1981, Stimulation of cellular proliferation in the adult rat submandibular gland during acute graft-versus-host disease, Transplantation 31:296–299.
Champlin, R. E., and Gale, R. P., 1984, Role of bone marrow transplantation in the treatment of hematologic malignancies and solid tumors: Critical review of syngeneic, antologous, and allogeneic transplants, Cancer Treat. Rep. 68:145–161.
O’Reilly, R. J., 1983, Allogeneic bone marrow transplantation: Current status and future directions, Blood 62:941–964.
Sullivan, K. M., Shulman, H. M., Storb, R., Weiden, P. L., Witherspoon, R. P., Schubert, M. M., Atkinson, K., and Thomas, E. D., 1981, Chronic graft-versus-host disease in 52 patients: Adverse natural course and successful treatment with combination immunosuppression, Blood 57:267–276.
Tsoi, M.-S., Storb, R., Dobbs, S., Medill, L., and Thomas, E. D., 1980, Cell mediated immunity to non-HLA antigens of the host by donor lymphocytes in patients with chronic graft-versus-host disease, J. Immunol. 125:2258–2262.
Maier, T., Holda, J. H., and Claman, H. N., 1985, Graft-vs-host reactions (GVHR) across minor murine histocompatibility barriers. II. Development of natural suppressor cell activity, J. Immunol. 135:1644–1651.
Streilein, J. W., 1972, Pathologic lesions of GVH disease in hamsters: Antigenic target versus “innocent bystanders,” Prog. Exp. Tumor Res. 16:396—408.
Lopez, C., Kirkpatrick, D., Sorell, M., and O’Reilly, R. J., 1979, Association between pretransplant natural killer and graft-versus-host disease after stem cell transplantation, Lancet 2:1103–1107.
Lotzova, E., and Cudkowicz, G., 1973, Assistance of irradiated Fl hybrid and allogeneic mice to bone marrow grafts of NZB donors, J. Immunol. 110:791–800.
Bortin, M. M., Truitt, R. L., Rimm, A. A., and Bach, F. H., 1979, Graft versus leukemia reactivity induced by alloimmunization without augmentation of graft versus host reactivity, Nature 281:490–491.
Lotzova, E., Savary, C. A., and Herberman, R. B., 1987, Induction of NK cell activity against fresh human leukemia in culture with interleukin 2, J. Immunol. 138:2718–2727.
Livnat, S., Seigneuret, M., Storb, R., and Prentice, R. L., 1980, Analysis of cytotoxic effector cell function in patients with leukemia or aplastic anemia before and after marrow transplantation, J. Immunol. 124:481–490.
Mizuno, S., Morishima, Y., Kodera, Y., Ohno, R., Yokomaku, S., Sao, H., and Yoshikawa, S., 1986, Gamma-interferon production capacity and T lymphocyte subpopula tion after allogeneic bone marrow transplantation. Transplantation 41:311–315.
Rooney, C. M., Wimperis, J. Z., Brenner, M. K., Patterson, B. J., Hoffbrand, A. V., and Prentice, H. G., 1986, Natural killer cell activity following T-cell depleted allogeneic bone marrow transplantation, Br. J. Haematol. 62:413–420.
DeVillartay, J. P., LeDeist, F., Griscelli, C., and Fischer, A., 1987, Dissociation between onset of natural killer E-rosette forming cells and of T3-positive cells following HLA-mismatched T cell depleted bone marrow transplantation, Clin. Exp. Immunol. 67:406– 414.
Parreira, A., Smith, J., Hows, J. M., Smithers, S. A., Apperley, J., Rombos, Y., Gordon-Smith, E. C. and Catovsky, D., 1987, Immunological reconstitution after bone marrow transplant with Campath-1 treated bone marrow, Clin. Exp. Immunol. 67:142–150.
Anderson, K. C., Ritz, J., Takvorian, T., Coral, F., Daley, H., Canellos, G. P., Schlossman, S. F., and Nadler, L. M., 1987, Hematologic engraftment and immune reconstitution posttransplantation with anti-B 1 purged autologous bone marrow, Blood 69:597–604.
Pattengale, P. K., Ramstedt, U., Gidlund, M., Orn, A., Axberg, I., and Wigzell, H., 1983, Natural killer activity in (C57BL/6 x DAB/2)F1 hybrids undergoing acute and chronic graft-vs.-host reaction, Eur. J. Immunol. 13:912–919.
Varkila, K., and Hurme, M., 1985, Natural killer (NK) cells and graft-versus-host disease (GVHD): No correlation between the NK cell levels and GVHD in the murine P-F1 model, Immunology 54:121–126.
Ford, W. L., Burr, W., and Simonsen, M., 1970, A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells. Transplantation 10:258–266.
Brideau, R. J., Carter, P. B., McMaster, W. R., Mason, D. W., and Williams, A. F., 1980, Two subsets of rat T lymphocytes defined with monoclonal antibodies, Eur. J. Immunol. 10:609–615.
Rolstad, B., Fossum, S., Hunt, S. V., and Ford, W. L., 1986, The host component of the popliteal lymph node graft-versus-host reaction. Selective representation of lymphocyte subsets and the requirement of alloantigenic incompatibility between donor cells and activated host B cells, Scand. J. Immunol. 23:589–598.
Reynolds, C. W., Timonen, T., and Herberman, R. B., 1981, Natural killer (NK) cell activity in the rat. I. Isolation and characterization of the effector cells, J. Immunol. 127:282–287.
Dokhelar, M.-C., Wiels, J., Lipinski, M., Tetaud, C., Devergie, A., Gluckman, E., and Tursz, T., 1981, Natural killer cell activity in human bone marrow recipients. Early reappearance of peripheral natural killer activity in graft-versus-host disease, Transplantation 31:61–65.
Gratama, J. W., Lipovich-Oosterveer, M. A., Ronteltap, C., Sinnige, L. G. F., Van der Griend, R. J., and Bolhuis, R. L. H., 1985, Natural immunity and graft-versus-host disease, Transplantation 40:256–260.
Favrot, M., Janossy, G., Tidman, N., Blacklock, H., Lopez, E., Bofill, M., Lambert, I., and Morgenstein, G., 1983, T cell regeneration after allogeneic bone marrow transplantation, Clin. Exp. Immunol. 54:59–72.
Janossy, G., Prentice, H. G., Grob, J.-P., Ivory, K., Tidman, N., Grundy, J., Griffiths, P. D., and Hoffbrand, A. V., 1986, T lymphocyte regeneration after transplantation of T cell depleted allogeneic bone marrow, Clin. Exp. Immunol. 63:577–586.
Lum, L. G., Seigneuret, M. C., Storb, R. F., Witherspoon, R. P., and Thomas, E. D., 1981, In vitroregulation of immunoglobulin synthesis after marrow transplantation. I. T-cell and B-cell deficiencies in patient with and without graft-versus-host disease, Blood 58:431–438.
Dosch, H. M., and Gelfand, E. W., 1981, Failure of T and B cell cooperation during graft-versus-host disease, Transplantation 31:48–50.
Matsue, K., Lum, L. G., Witherspoon, R. P., and Storb, R., 1987, Proliferative and differentiative response of B cells from human marrow graft recipients to T cell-derived factors, Blood 69:308–315.
Brenner, M. K., Reittie, J. E., Grob, J.-P., Wimperis, J. Z., Stephens, S., Patterson, J., Hoffbrand, A. V., and Prentice, H. G., 1986, The contribution of large granular lymphocytes to B cell activation and differentation after T-cell-depleted allogeneic bone marrow transplantation, Transplantation 42:257–261.
Brenner, M. K., Vyakarnam, A., Reittie, J. E., Wimperis, J. Z., Grob, J. P., Hoffbrand, A. V., and Prentice, H. G., 1987, Human large granular lymphocytes induce immunoglobulin synthesis after bone marrow transplantation, Eur. J. Immunol. 17:43–47.
Weiden, P. L., Flournoy, N., Thomas, E. D., Prentice, R., Fefer, A., Buckner, C. D., and Storb, R., 1979, Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts, N. Engl. J. Med. 300:1068–1073.
Hercend, T., Takvorian, T., Nowill, A., Tantravahi, R., Moingeon, P., Anderson, K. C., Ytheir, A., and Ritz, J., 1986, Characterization of natural killer cells with antileukemia activity following allogeneic bone marrow transplantation, Blood 67:722–728.
Slavin, R., and Santos, G., 1973, The graft versus host reaction in man after bone marrow transplantation: Pathology, pathogenesis, clinical features, and implication, Clin. Immunol. Immunopathol. 1:472–498.
Bernnan, D., Gisselbrecht, C., Devergie, A., Feldman, G., Gluckman, E., Martz, M., and Bviron, M., 1980, Histological and ultrastructural appearance of the liver during graft-versus-host disease complicating bone marrow transplantation, Transplantation 29:236–244.
Dilly, S. A., and Sloane, J. R., 1985, An immunohistological study of human hepatic graft-versus-host disease, Clin. Exp. Immunol. 62:545–553.
Sloane, J. P., Thomas, J. A., Imrie, S. F., Easton, D. F., and Powles, R. L., 1984, Morphological and immunohistological changes in the skin in allogeneic bone marrow recipients, J. Clin. Pathol. 37:919–930.
Dilly, S. A., and Sloane, J. P., 1987, Changes in rectal leukocytes after allogeneic bone marrow transplantation, Clin. Exp. Immunol. 67:151–158.
Roy, C., Ghayur, T., Kongshavn, P. A. L., and Lapp, W. S., 1982, Natural killer activity by spleen, lymph node, and thymus cells during graft-versus-host reaction, Transplantation 34:144–146.
Ghayur, T., Seemayer, T. A., and Lapp, W. S., 1987, Kinetics of natural killer (NK) cell cytotoxicity during the graft-versus-host reaction. Relationship between NK cell activity, T and B activity, and development of histopathological alterations, Transplantation 44:254–260.
Ghayur, T., Seemayer, T. A., and Lapp, W. S., 1988, Prevention of marine graft-versus-host disease by inducing and eliminating ASGM1+ cells of donor origin, Transplantation 45:586–590.
Ghayur, T., Seemayer, T. A., Kongshavn, P. A. L., Gartner, J. G., and Lapp, W. S., 1987, Graft-versus-host (GVH) reactions in the beige mouse: An investigation of the role of host and donor natural killer (NK) cells in the pathogenesis of GVH disease, Transplantation 44:261–267.
Borland, A., Mowat, A. I., and Parrott, D. M. V., 1983, Augmentation of intestinal and peripheral natural killer cell activity during graft-versus-host reaction in mice, Transplantation 36:513–519.
Guy-Grand, D., Griscelli, C., and Vassalli, P., 1978, The moust gut T lymphocyte, a novel type of T cell, J. Exp. Med. 148:1661–1677.
Mowat, A., 1986, Evidence that Ia+ bone-marrow-derived cells are stimulus for the intestinal phase of the murine graft-versus-host reaction, Transplantation 42:141–144.
Charley, M. R., Mikhael, A., Bennett, M., Gilliam, J. N., and Sontheimer, R. D., 1983, Prevention of lethal, minor-determinate graft-versus-host disease in mice by the in vivo administration of anti—asialo GMI, J. Immunol. 131:2101–2103.
Charley, M. R., Mikhael, A., Hoot, G., Hackett, J., and Bennett, M., 1985, Studies addressing the mechanism of anti—asialo GM1 prevention of graft-versus-host disease due to minor histocompatibility antigenic differences,J. Invest. Dermatol. 85:121S–123S.
Ting, C.-C., Bluestone, J. A., Hargrove, M. E., and Loh, N.-N., 1986, Expression and function of asialo GM1 in alloreactive cytotoxic T lymphocytes, J. Immunol. 137:2100–2106.
Thiele, D. L., Charley, M. R., Calomeni, J. A., and Lipsky, P. E., 1987, Lethal graft-versus-host disease across major histocompatibility barriers: requirement for leucyl-leucine methyl ester sensitive cytotoxic T cells. J. Immunol. 138:51–57.
Guillen, R. J., Ferrara, J., Hancock, W. W., Messadi, D., Fonferko, E., Burakoff, S. J., and Murphy, G. F., 1986, Acute cutaneous graft-versus-host disease to minor histocompatibility antigens in murine model, Lab. Invest. 55:35–42.
Romani, N., Stingl, G., Tschachler, E., Witmer, M. D., Steinman, R. M., Shevch, E. M., and Schuler, G., 1985, The Thy-1-bearing cell of murine epidermis. A distinctive leukocyte perhaps related to natural killer cells, J. Exp. Med. 161:1368–1383.
Clancy, J. Jr., Mauser, L., and Chapman, A. L., 1983, Level and temporal pattern of naturally cytolytic cells during acute graft-versus-host disease (GVHD) in the rat, Cell. Immunol. 79:1–10.
Renkonen, R., and Hayry, P., 1984, Bone marrow transplantation in the rat. I. Histologic correlations and quantitation of cellular infiltrates in acute graft-versus-host disease, Am. J. Pathol. 117:462–470.
Stet, R. J. M., Thomas, C., Koudstaal, J., Hardonk, M. J., Hulstaert, C. E., and Nieuwenhuis, P., 1986, Graft-versus-host disease in the rat: Cellular changes and major histocompatibility complex antigen expression in the liver, Scand.J. Immunol. 23:81–89.
Wisse, E., Van’t Noordende, J. M., Van der Menlen, J., and Deams, W. T., 1976, The pit cell: Description of a new cell occurring in rat liver sinusoids and peripheral blood, Cell Tissue Res. 173:423–435.
Rolstad, B., Fossum, S., Bazin, H., Kimber, I., Marshall, J., Sparshott, S. M., and Ford, W. L., 1985, The rapid rejection of allogeneic lymphocytes by a non-adaptive, cell-me-diated mechanism (NK activity), Immunology 54:127–138.
Kasahara, T., Djeu, J. Y., Dougherty, S. F., and Oppenheim, J. J., 1983, Capacity of human large granular lymphocytes (LGL) to produce multiple lymphokines: Interleukin 2, interferon, and colony stimulating factor, J. Immunol. 131:2379–2385.
Grimm, E. A., Mazumder, A., Zhang, H. Z., and Rosenberg, S. A., 1982, Lymphokine-activated killer cell phenomenon. Lysis of natural killer—resistant fresh solid tumor cells by interleukin 2—activated antologous human peripheral blood lymphocytes, J. Exp. Med. 155:1823–1841.
Mori, T., Tsoi, M.-S., Gillis, S., Santos, E., Thomas, E. D., and Storb, R., 1983, Cellular interactions in marrow-grafted patients. I. Impairment of cell-mediated lympholysis associated with graft-vs-host disease and the effect of interleukin 2, J. Immunol. 130:712–716.
Merluzzi, V. J., Welte, K., Last-Barney, K., Mertelsmann, R., Souza, L., Savage, D. M., Quinn, D., and O’Reilly, R. J., 1985, Production and response to interleukin 2 in vitroand in vivoafter bone marrow transplantation in mice, J. Immunol. 134:2426–2430.
Malkovsky, M., Brenner, M. K., Hunt, R., Rastan, S., Dore, C., Asherson, G. L., Prentice, H. G., and Medawar, P. B., 1986, T-cell depletion of allogeneic bone marrow prevents acceleration of graft-versus-host disease induced by exogenous interleukin 2, Cell Immunol. 103:476–480.
Clancy, J. Jr., Goral, J., Triner, J., and Ellis, T., 1987, Increased activation of YAC-1 killer (natural killers: NK) versus Daudi killers (lymphokine activated killers: LAK) by spleen cells from control and acute graft versus host disease (AGVHD) rats by recombinant IL-2 (Ril-2), Anat. Rec. 218:25A.
Volk, H.-D., Brocke, S., Osawa, H., and Diamantstein, T., 1986, Suppression of the local graft-vs.-host reaction in rats by treatment with a monoclonal antibody specific for the interleukin 2 receptor, Eur. J. Immunol. 16:1309–1312.
Diamanstein, T., Volk, H.-D., Tilney, N. L., and Kupiec-Weglinski, J., 1986, Specific immunosuppressive therapy by monoclonal anti-IL-2 receptor antibody and its synergistic action with cyclosporin, Immunobiology 172:391–399.
Ferrara, J. L. M., Marion, A., Mclntyre, J. F., Murphy, G. F., and Burakoff, S. J., 1986, Amelioration of acute graft vs host disease due to minor histocompatibility antigens by in vivo administration of anti-interleukin 2 receptor antibody, J. Immunol. 137:1874–1877.
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© 1989 Plenum Press, New York
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Clancy, J. (1989). Involvement of Natural Effector Cells in Graft versus Host Disease. In: Reynolds, C.W., Wiltrout, R.H. (eds) Functions of the Natural Immune System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0715-0_16
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DOI: https://doi.org/10.1007/978-1-4613-0715-0_16
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