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Control of Hematopoietic Progenitor Cells by Natural Killer Cells

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Book cover Functions of the Natural Immune System

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Abstract

In adult animals and in physiological conditions, hematopoiesis occurs only in the bone marrow and in lymphoid organs, and it is not observed in organs such as liver or spleen, sites of fetal hematopoiesis. Precursor cells committed to erythroid and myeloid hematopoietic lineages originate from pluripotent stem cells and, through several cycles of cell division, give rise to terminally differentiated cells.(1) The entire process of hematopoiesis is regulated by the equilibrium between the self-renewal capability of the stem cell and the commitment to differentiate along one or more hematopoietic lineages. The maintenance of this equilibrium underlies the hematopoietic homeostasis necessary for the continuous production of the different types of hematopoietic cells required in physiological conditions. The regulation of hematopoiesis is also sufficiently flexible to enable hematopoietic organs to respond effectively to pathological situations (e.g., during bleeding or infections) requiring a rapidly increased production of a particular blood cell type.

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Authors and Affiliations

  1. Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, 19104, USA

    Giorgio Trinchieri, Marianne Murphy, Maria Cristina Cuturi, Ignacio Anegon & Bice Perussia

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  1. Giorgio Trinchieri
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  2. Marianne Murphy
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  1. Frederick Cancer Research Facility, National Cancer Institute, Frederick, Maryland, USA

    Robert H. Wiltrout

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© 1989 Plenum Press, New York

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Trinchieri, G., Murphy, M., Cuturi, M.C., Anegon, I., Perussia, B. (1989). Control of Hematopoietic Progenitor Cells by Natural Killer Cells. In: Reynolds, C.W., Wiltrout, R.H. (eds) Functions of the Natural Immune System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0715-0_11

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  • DOI: https://doi.org/10.1007/978-1-4613-0715-0_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8046-0

  • Online ISBN: 978-1-4613-0715-0

  • eBook Packages: Springer Book Archive

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