Photoprotective Role of Melanin (Eumelanin) in Human Skin
Natural light and UV radiation (UVR) from artificial sources has always been recognized for and endowed with health-giving powers as well as for its tonic value of generating a feeling that it is good for our psyche and contributes to the synthesis of vitamin D essential for maintaining calcium and phosphorus homeostasis and a healthy skeleton. It provides the healthy looking tan that enhances the photoprotective properties of our skin against skin cancer and photoaging.
KeywordsSkin Cancer Stratum Corneum Skin Type Stable Free Radical Urocanic Acid
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- 1.Pathak, M.A.,The role of natural photoprotective agents in human skin,in: “Sunlight and Man”, M.A. Pathak, L.C. Harber, M. Seiji, and A. Kukita, eds., Univ. Tokyo Press, Tokyo, pp. 725–750 (1974).Google Scholar
- 2.Pathak, M.A., Fitzpatrick, T.B., Greiter, F.J., and Kraus, E.W., Preventive treatment of sunburn, dermatoheliosis, and skin cancer with sun protective agents,in: “Dermatology in General Medicine”, T.B. Fitzpatrick, A.Z. Eisen, K. Wolff, et al., eds., 3rd ed., McGraw-Hill Book Company, New York, pp. 1507–1522 (1987).Google Scholar
- 5.Urbach, F.,Photocarcinogenesis,in: “The Science of Photomedicine”, J.D. Regan and J.A. Parrish, eds., Plenum Press, New York, pp. 261–292 (1982).Google Scholar
- 6.Pathak, M.A., Jimbow, K., Szabo, G., and Fitzpatrick, T.B., Sunlight and melanin pigmentation,in: “Photochemical and Photobiological Reviews”, K.C. Smith, ed., Plenum Press, New York, pp. 211–239 (1976).Google Scholar
- 7.Pathak, M.A.,Immediate and delayed pigmentary and other cutaneous responses to solar UVA radiation (320–400 nm),in: “The Biological Effects of UVA Radiation”, F. Urbach and R.W. Gange, eds., Praeger Publishers, New York, pp. 156–167 (1986).Google Scholar
- 10.Pathak, M.A.,Photobiology of melanogenesis: Biophysical aspects,in: “Advances of Biology of Skin; the Pigmentary System”, W. Montagna and F. Hu, eds., Vol. 8, Pergamon Press, Oxford, pp. 387–420 (1967).Google Scholar
- 14.Pathak, M.A., Reactive oxygen species and free radicals in sunlight-induced skin reactions, J. Am. Oil Chemists Soc. 64:630 (1987).Google Scholar