Abstract
Excessive exposure to sunlight is the major etiologic factor in the development of squamous cell carcinomas, basal cell carcinomas and possibly malignant melanomas. Ultraviolet (UV) light mediated carcinogenesis is a complex process which is not completely understood. First, chronic exposure of animals to UV light shows that it acts both as a tumor initiator and promotor upon epidermal cells (EC). Secondly, it may impair the body’s immune response to the altered ECs permitting the survival and growth of neoplastic epidermal cells (1). In particular mice exposed to UV light develop T-suppressor lymphocytes that prevent 1. sensitization to potent contact allergens (2) and 2. immunologic rejection of highly antigenic UV induced skin cancer (3). Immunologic alterations that occur following exposure to UV radiation can be divided into two types: local and systemic immunosuppression.
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Schwarz, T., Urbanski, A., Gschnait, F., Luger, T.A. (1988). UVB Induced Production of Keratinocyte Derived Suppressor Factors. In: Douglas, R.H., Moan, J., Dall’Acqua, F. (eds) Light in Biology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0709-9_39
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DOI: https://doi.org/10.1007/978-1-4613-0709-9_39
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