Advertisement

Quantification of 31P NMR in vivo Spectra

  • T. R. Brown
  • S. J. Nelson
  • J. S. Taylor
  • D. B. Vigneron
  • J. Murphy-Boesch
Part of the Developments in Oncology book series (DION, volume 61)

Abstract

As exemplified by a number of papers in this volume, the clinical 31P NMR data now available is provocative regarding its diagnostic and therapeutic utility. To validate and extend these early results, spectra must be produced from well-defined locations which can be accurately mapped to anatomical features. These specta need to be quantified reproducibly and accurately. Local sensitivity factors are also required so that absolute concentrations can be obtained. Furthermore, if multi-voxel localization techniques such as chemical shift imaging (CSI) are used, the spectral analysis must be performed automatically since several hundred spectra can be acquired in only a few minutes.

Keywords

Maximum Entropy Method Metabolic Image Spectroscopic Magnetic Resonance Imaging Localize Spectrum Radiofrequency Field 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ackerman JJH, Grove TH, Wong GC et al: Mapping of metabolites in whole animals by 31P NMR using surface coils. Nature 283:167–170, 1980.PubMedCrossRefGoogle Scholar
  2. 2.
    Maris JM, Evans AE, McLaughlin AC et al: 31P Nuclear magnetic resonance spectroscopic investigation of human neuroblastoma in vivo. New Engl. J. Med. 312:1500–1505, 1985.PubMedCrossRefGoogle Scholar
  3. 3.
    Ng TC, Vijayakumar S, Majors AW et al: Response of non-Hodgkins lymphoma to 60Co therapy monitored by 31P MRS in situ. Int. J. Radiat. Oncol. Biol. Phys. 13:1545–1551, 1987.PubMedCrossRefGoogle Scholar
  4. 4.
    Semmler W, Gademann G, Bachert-Baumann P et al: Monitoring human tumor response to therapy by means of P-31 MR spectroscopy. Radiology, in press.Google Scholar
  5. 5.
    Ordidge RJ, Connelly A, Lohman JAB: Image-selective in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy. J. Magn. Reson. 66:283–290, 1986.Google Scholar
  6. 6.
    Ordidge RJ, Bowley RM, McHale G: A general approach to selection of multiple cubic volume elements using the ISIS technique. Magn. Reson. Med. 8:323–331, 1988.PubMedCrossRefGoogle Scholar
  7. 7.
    Muller S, Sauter R, Weber H, Seelig J: Multivolume selective spectroscopy. J. Magn. Reson. 76:155–161, 1988.Google Scholar
  8. 8.
    Brown TR, Kincaid BM, Ugurbil K: NMR chemical shift imaging in three dimensions. Proc. Natl. Acad. Sci. USA 79:3523–3526, 1982.PubMedCrossRefGoogle Scholar
  9. 9.
    Maudsley AA, Hilal SK, Perman WH, Simon HE: Spatially resolved high resolution spectroscopy by four-dimensional NMR. J. Magn. Reson. 51:147–152, 1983.Google Scholar
  10. 10.
    Barkhuusen H, de Beer R, Bovee WMMJ, van Ormondt D: Retrieval of frequencies, amplitudes, damping factors, and phases from time-domain signals using a linear least-squares procedure. J. Magn. Reson. 61:465, 1985.Google Scholar
  11. 11.
    Hore PJ: NMR data processing using the maximum entropy method. J. Magn. Reson. 62:561, 1985.Google Scholar
  12. 12.
    Laue ED, Skilling J, Staunton J et al: Maximum entropy method in nuclear magnetic resonance spectroscopy. J. Magn. Reson. 62:437, 1985.Google Scholar
  13. 13.
    Laue ED, Skilling J, Staunton J: Maximum entropy reconstruction of spectra containing antiphase peaks. J. Magn. Reson. 673:418, 1985.Google Scholar
  14. 14.
    Ni F, Levy GC, Scheraga HA: Simultaneous resolution enhancement and noise suppression in NMR signal processing by combined use of maximum entropy and Fourier self-deconvolution methods. J. Magn. Reson. 66:385, 1986.Google Scholar
  15. 15.
    Macovski A, Spielman D: In vivo spectroscopic magnetic resonance imaging using estimation theory. Magn. Reson. Med. 3:97–104, 1986.PubMedCrossRefGoogle Scholar
  16. 16.
    Spielman D, Webb P, Macovski A: A statistical framework for in vivo spectroscopic imaging. J. Magn. Reson. 79:66–77, 1988.Google Scholar
  17. 17.
    Nelson SJ, Brown TR: NMR data processing using the maximum entropy method. J. Magn. Reson. 75:229–243, 1987.Google Scholar
  18. 18.
    Nelson SJ, Brown TR: The accuracy of quantification from 1-D NMR spectra using the PIQABLE algorithm. J. Magn. Reson. 84:95–109, 1989.Google Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1990

Authors and Affiliations

  • T. R. Brown
  • S. J. Nelson
  • J. S. Taylor
  • D. B. Vigneron
  • J. Murphy-Boesch

There are no affiliations available

Personalised recommendations