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13C and 31P NMR Studies of Prostate Tumor Metabolism

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Magnetic Resonance in Experimental and Clinical Oncology

Part of the book series: Developments in Oncology ((DION,volume 61))

Abstract

In 1989 an estimated 104,000 cases of prostatic adenocarcinoma will account for about 20% of all male cancers and 11% of all male cancer-related deaths in the U.S.A. As the U.S. population ages, the incidence of this specific tumor type, which is most common in males over 50 years of age, will increase substantially. Prostatic cancers display widely-varying growth rates which impact on the prognosis and required therapeutic intervention. Histologic examination of tumor types is widely used to correlate morphology with growth rates, but there are still histologically-similar tumors which vary markedly in growth characteristics. Neoplasia differs from normal cellular growth in the expression of one or more genes, a feature of cancer which can result in an altered metabolism of tumor cells. We are using Nuclear Magnetic Resonance Spectroscopy (NMRS), a non-invasive and non-destructive method for observing metabolic events both in vitro and in vivo (1–22), to elucidate these metabolic alterations in prostate tumors with the goal of improving our basic understanding of the oncogenetic process in this organ.

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Authors
  1. Laurel O. Sillerud
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  2. Karen R. Halliday
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  3. James P. Freyer
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  4. Richard H. Griffey
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  5. Cecilia Fenoglio-Preiser
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Editor information

Editors and Affiliations

  1. Wayne State University School of Medicine, Detroit, Michigan, USA

    Jeffrey L. Evelhoch , William Negendank , Frederick A. Valeriote  & Laurence H. Baker , ,  & 

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© 1990 Kluwer Academic Publishers, Boston

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Sillerud, L.O., Halliday, K.R., Freyer, J.P., Griffey, R.H., Fenoglio-Preiser, C. (1990). 13C and 31P NMR Studies of Prostate Tumor Metabolism. In: Evelhoch, J.L., Negendank, W., Valeriote, F.A., Baker, L.H. (eds) Magnetic Resonance in Experimental and Clinical Oncology. Developments in Oncology, vol 61. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0691-7_6

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  • DOI: https://doi.org/10.1007/978-1-4613-0691-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8028-6

  • Online ISBN: 978-1-4613-0691-7

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