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Combined MRI and 31P MRS for Diagnosis of Bone and Soft Tissue Lesions

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Magnetic Resonance in Experimental and Clinical Oncology

Part of the book series: Developments in Oncology ((DION,volume 61))

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Abstract

The excellent contrast resolution obtained with MRI makes it useful for determining the anatomic extent of malignant lesions of bone and soft tissue and for assessing the degree of marrow invasion by bone sarcomas (1–16). However, MRI lacks diagnostic specificity; that is to say, the appearance of malignant lesions of bone and soft tissue, in both T1- and T2- weighted images, is often very similar to that of benign tumors, hemangiomas, and infections (6,7,14,16–18). Our experience in over 100 cases confirms this impression. In the study reviewed here, we asked the question whether or not the diagnostic specificity of an MR study could be increased by combining 31P MRS with the MRI. The rationale is based on the observations, made in a number of animal and human cancers (reviewed in references 19–24), that cancers frequently have characteristic 31P MR spectra. These characteristics include a high phosphomonoester (PME) peak, a high phosphodiester (PDE) peak, and a low phosphocreatine (PCr) peak. A high PME peak has been observed in several cases of bone and soft tissue cancers in man (25–31).

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Authors
  1. W. G. Negendank
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  2. M. G. Crowley
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  3. J. R. Ryan
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  4. N. A. Keller
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  5. J. L. Evelhoch
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Editor information

Editors and Affiliations

  1. Wayne State University School of Medicine, Detroit, Michigan, USA

    Jeffrey L. Evelhoch , William Negendank , Frederick A. Valeriote  & Laurence H. Baker , ,  & 

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© 1990 Kluwer Academic Publishers, Boston

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Negendank, W.G., Crowley, M.G., Ryan, J.R., Keller, N.A., Evelhoch, J.L. (1990). Combined MRI and 31P MRS for Diagnosis of Bone and Soft Tissue Lesions. In: Evelhoch, J.L., Negendank, W., Valeriote, F.A., Baker, L.H. (eds) Magnetic Resonance in Experimental and Clinical Oncology. Developments in Oncology, vol 61. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0691-7_13

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  • DOI: https://doi.org/10.1007/978-1-4613-0691-7_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8028-6

  • Online ISBN: 978-1-4613-0691-7

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