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Magnetic Resonance in Experimental and Clinical Oncology pp 231–253Cite as

In Situ 31P-MRS as a Potential Predictor for Therapeutic Response of Human Neoplasms

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Part of the book series: Developments in Oncology ((DION,volume 61))

Abstract

Prediction of radiocurability, chemotherapeutic sensitivity or other therapeutic efficacy of cancer by means of laboratory tests has long been searched for. For example, Glucksmann and coworkers tried to correlate histopathological changes to clinical outcome in individual patients (with uterine cervical carcinoma) as early as 1941 (1). Atkin et al. (2) showed (on human cervical cancer cells) that cancers with near-diploid DNA content tended to be more radioresistant than tetraploid tumors. Kolstad (3) correlated the tissue oxygen concentration with the initial response to radiotherapy. Potential lethal damage repair (PLDR) and labeling index depression has been used by Weishselbaum (4) and Tubiana and Malaise (5) respectively to estimate radiocurability. In prediction of tumor response to chemotherapeutic agents, the stem cell assay (6,7) has been employed. Others have studied in vitro radiobiological parameters as potential predictors (8,9). However, all these predictive assays are invasive, time consuming procedures and lack accuracy due to heterogeneity of tumors and limited by biopsying only a very small part of the tumor mass.

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Authors
  1. Thian C. Ng
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  2. S. Vijayakumar
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  3. A. Majors
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  4. Melvin Tefft
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Editor information

Editors and Affiliations

  1. Wayne State University School of Medicine, Detroit, Michigan, USA

    Jeffrey L. Evelhoch , William Negendank , Frederick A. Valeriote  & Laurence H. Baker , ,  & 

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© 1990 Kluwer Academic Publishers, Boston

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Ng, T.C., Vijayakumar, S., Majors, A., Tefft, M. (1990). In Situ 31P-MRS as a Potential Predictor for Therapeutic Response of Human Neoplasms. In: Evelhoch, J.L., Negendank, W., Valeriote, F.A., Baker, L.H. (eds) Magnetic Resonance in Experimental and Clinical Oncology. Developments in Oncology, vol 61. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0691-7_10

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  • DOI: https://doi.org/10.1007/978-1-4613-0691-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8028-6

  • Online ISBN: 978-1-4613-0691-7

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