Tubular and Metabolic Dysfunction Following Kidney Transplantation

  • J. Winaver
  • J. Green
  • O. S. Better


The transplanted kidney is exposed to a wide range of injuries. These may afflict the kidney before, during, and after the surgical procedure. The trauma, shock, or morbidity that caused the death of the donor may affect the kidney even before the operation. In addition, the handling of the kidney, the extracorporeal perfusion, and the surgery itself may cause damage to the kidney during the operative and perioperative phase. After transplantation the kidney is also subjected to rejection and other deleterious conditions (summarized in Table 1). The resulting kidney damage is frequently associated with a generalized decrease in renal function characterized by oliguria or anuria of variable duration. Occasionally, however, despite this hostile environment, the glomerular filtration rate is relatively spared and the injury is predominantly tubulointerstitial (see Table 2). These tubular syndromes may cause profound changes in the acid-base balance and disturbances in electrolyte and mineral homeostasis, which may aggravate preexisting bone disease and lead to nephrocalcinosis or nephrolithiasis.


Familial Mediterranean Fever Renal Artery Stenosis Renal Tubular Acidosis Familial Mediterranean Fever Patient Obstructive Uropathy 
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Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • J. Winaver
  • J. Green
  • O. S. Better

There are no affiliations available

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