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Abstract

Clinical relationships between uric acid and the human kidney have long been a topic of perennial interest (1). In this chapter we shall review the different types of renal involvement caused by uric acid or urate, and summarize the available treatment modalities.

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References

  1. Steele TH: Urate excretion in man, normal and gouty. In: WN Kelley, IM Weiner, eds, Uric Acid. Handbook of Experimental Pharmacology, Vol 51. Springer-Verlag, Berlin, pp 257–286, 1978.

    Google Scholar 

  2. Rieselbach RE, Bentzel CJ, Cotlove E, Frei E III, Freireich J: Uric acid excretion and renal function in the acute hyperuricemic of leukemia. Am J Med 37:876–884, 1964.

    Article  Google Scholar 

  3. Conger JD: Acute uric acid nephropathy. Semin Nephrol 1:69–74, 1981.

    CAS  Google Scholar 

  4. Wilcox WR, Khalaf A, Weinberger A, Kippen I, Klinenberg JR: Solubility of uric acid and monosodium urate. Med Biol Eng Comput 10:522–531, 1972.

    CAS  Google Scholar 

  5. Finlayson B, Smith A: Stability of the first dissociable proton of uric acid. J Chem Eng Data 19:94–97, 1974.

    Article  CAS  Google Scholar 

  6. Yü T-F, Gutman A: Uric acid nephrolithiasis in gout: Predisposing factors. Ann Intern Med 67:1133–1148, 1967.

    PubMed  Google Scholar 

  7. Conger JD, Falk SA, Guggenheim SJ, Burke TJ: A micro-puncture study of the early phase of acute urate nephropathy. J Clin Invest 58:681–689, 1976.

    Article  PubMed  CAS  Google Scholar 

  8. Emmerson BT, Row PG: An evaluation of the pathogenesis of the gouty kidney. Kidney Int 8:65–71, 1975.

    Article  PubMed  CAS  Google Scholar 

  9. Jenkins P, Rieselbach RE: Unique characteristics of the mechanism for reabsorption of filtered versus secreted urate (abstract). Proc Am Soc Clin Invest 36A, 1974.

    Google Scholar 

  10. Passwell J, Boichis H, Cohen BE: Hyperuricemic nephropathy. Am J Dis Child 120:154–156, 1970.

    PubMed  CAS  Google Scholar 

  11. Kanwar F, Maraligod J: Leukemic urate nephropathy. Arch Pathol 99:467–472, 1975.

    PubMed  CAS  Google Scholar 

  12. Merrill D, Jackson H: The renal complications of leukemia. N Engl J Med 228:271–276, 1943.

    Article  Google Scholar 

  13. Cohen LF, Balow JE, Magrath IT, Poplack DG, Ziegler JL: Acute tumor lysis syndrome. Am J Med 68:486–491, 1980.

    Article  PubMed  CAS  Google Scholar 

  14. Tsokos GC, Balow JE, Spiegel RJ, Magrath, IT: Renal and metabolic complications of undifferentiated and lymphoblastic lymphomas. Medicine 60:218–229, 1981.

    Article  PubMed  CAS  Google Scholar 

  15. Crittenden DR, Ackerman GL: Hyperuricemic acute renal failure in disseminated carcinoma. Arch Intern Med 137:97–99, 1977.

    Article  PubMed  CAS  Google Scholar 

  16. Ultmann JE: Hyperuricemia in disseminated neoplastic disease other than lymphomas and leukemias. Cancer 15: 122–129, 1962.

    Article  PubMed  CAS  Google Scholar 

  17. Emmerson BT, Thompson L: The spectrum of hypoxanthi-neguanine phosphoribosyl transferase deficiency. Q J Med 42:423–440, 1973.

    PubMed  CAS  Google Scholar 

  18. Bennett WM, Van Zee BE, Hutchings R, Cohen LH, Norby LH, Champion C, Spargo B, Selby T: Acute renal failure from ticrynafen. N Engl J Med 301:1179–1181, 1979.

    Article  PubMed  CAS  Google Scholar 

  19. Wolfe SM: Suprofen-induced transient flank pain and renal failure. Engl J Med 316:1025, 1987.

    Article  CAS  Google Scholar 

  20. Suprofen labelling revised. FDA Drug Bulletin 16;15–16, 1986.

    Google Scholar 

  21. Ahmadian Y, Lewy P: Possible urate nephropathy of the newborn infant as a cause of transient renal insufficiency. J Pediatr 91:96–100, 1977.

    Article  PubMed  CAS  Google Scholar 

  22. Warren DJ, Leitch AG, Leggett RJE: Hyperuricemic acute renal failure after epileptic seizures. Lancet 2:385–387, 1975.

    Article  PubMed  CAS  Google Scholar 

  23. Holland P, Holland N: Prevention and management of acute hyperuricemia in childhood leukemia. J Pediatr 72:358–366, 1972.

    Google Scholar 

  24. Yolken RH, Miller DR: Hyperuricemia and renal failure — presenting manifestations of occult hematologic malignancies. J Pediatr 89:775–777, 1976.

    Article  CAS  Google Scholar 

  25. Lear H, Oppenheimer GD: Anuria following radiation therapy in leukemia. JAMA 143:806–807, 1950.

    CAS  Google Scholar 

  26. Watts RWE, Watkins PJ, Mathias JQ: Allopurinol and acute uric acid nephropathy. B Med J 1:205–208, 1966.

    Article  CAS  Google Scholar 

  27. Kritzler RA: Anuria complicating the treatment of leukemia. Am J Med 25:532–538, 1958.

    Article  PubMed  CAS  Google Scholar 

  28. Alsarraf D, Reese L: Management of acute renal failure due to marked hyperuricemia. Can Med Assoc J 106:352–354, 1972.

    PubMed  CAS  Google Scholar 

  29. Howorth PJN, Zilva JF: Determination of uric acid levels in uraemia by enzymatic and colorimetric techniques. J Clin Pathol 21:192–195, 1968.

    Article  PubMed  CAS  Google Scholar 

  30. Caraway WT: Non-urate chromogens in body fluids. Clin Chem 15:720–726, 1969.

    PubMed  CAS  Google Scholar 

  31. Prien EL, Prien EL Jr: Composition and structure of urinary stone. Am J Med 45:654–672, 1968.

    Article  PubMed  CAS  Google Scholar 

  32. Kelton J, Kelley WN, Holmes EW: A rapid method for the diagnosis of acute uric acid nephropathy. Arch Intern Med 138:612–615, 1978.

    Article  PubMed  CAS  Google Scholar 

  33. Tangsanga K, Boonwichit D, Lekhakula A, Sitprija V: Urine uric acid and urine creatinine ratio in acute renal failure. Arch Intern Med 144:934–937, 1984.

    Article  Google Scholar 

  34. Kanfer A, Richet G, Roland J, Chatelet F: Extreme hyperphosphatemia causing acute anuric nephrocalcinosis in lymphosarcoma. B Med J 1:1320, 1979.

    Article  CAS  Google Scholar 

  35. Conger JD, Falk SA: Intrarenal dynamics in the pathogenesis and prevention of acute urate nephropathy. J Clin Invest 59:127–128, 1978.

    Google Scholar 

  36. Higenbottam T, Ogg CS, Saxton HM: Acute renal failure from the use of acetazolamide (Diamox). Postgrad Med J 54:127–128, 1978.

    Article  PubMed  CAS  Google Scholar 

  37. Barry KG, Hunter RH, Davis TE, Crosby WA: Acute uric acid nephropathy. Arch Intern Med 111:452–459, 1963.

    PubMed  CAS  Google Scholar 

  38. Handa SP: Acute renal failure in association with hyperuricemia. South Med J 64:676–678, 1971.

    Article  PubMed  CAS  Google Scholar 

  39. Anderson RJ, Linas SL, Berns As, Henrich WL, Miller TR, Gabow PA, Schrier RW: Non-oliguric acute renal failure. N Engl J Med 296:1134–1138, 1977.

    Article  PubMed  CAS  Google Scholar 

  40. Schrier RW: Acute renal failure. Kidney Int 15:205–216, 1979.

    Article  PubMed  CAS  Google Scholar 

  41. DeConti RC, Calabresi P: Use of Allopurinol for prevention and control of hyperuricemia in patients with neoplastic disease. N Engl J Med 274:481–486, 1966.

    Article  PubMed  CAS  Google Scholar 

  42. Bard PR, Silverberg DS, Henderson JF, Ulan RA, Wensel RH, Banerjee TK, Little AS: Xanthine nephropathy in a patient with lymphosarcoma treated with allopurinol. N Engl J Med 283:354–357, 1970.

    Article  Google Scholar 

  43. Albin A, Stephens BG, Hirata T, Wilson K, Williams HE: Nephropathy, xanthinuria, and orotic aciduria complicating Burkitt’s lymphoma treated with chemotherapy and allopurinol. Metabolism 21:771–778, 1972.

    Article  Google Scholar 

  44. Elion GB: Allopurinol and other inhibitors of urate synthesis. In: WN Kelley, IM Weiner, eds, Uric Acid. Handbook of Experimental Pharmacology, Vol 51. Springer-Verlag, Berlin, pp 485–514, 1978.

    Google Scholar 

  45. Edwards NL, Recker D, Airozo D, Fox IH: Enhanced purine salvage during allopurinol therapy: An important pharmacologic property in humans. J Lab Clin Med 98:673–682, 1981.

    PubMed  CAS  Google Scholar 

  46. Hande KR, Perini F, Putterman G, Elin R: Hyperxanthinemia inteferes with serum uric acid determinations by the uricase method. Clin Chem 25:1492–1494, 1979.

    PubMed  CAS  Google Scholar 

  47. Kann HE Jr, Wells JH, Gallelli JF, Schein PS, Cooney DA, Smith ER, Seegmiller JE, Carbone PP: The development and use of an intravenous preparation of allopurinol. Am J Med Sci 256:53–63, 1968.

    Article  PubMed  CAS  Google Scholar 

  48. Hande K, Noone R, Stone W: Severe allopurinol toxicity description and guildines for prevention in patients with renal insufficiency. Am J Med 76:47–56, 1984.

    Article  PubMed  CAS  Google Scholar 

  49. Elion GB, Yü T-F, Gutman AB, Hitchings GH: Renal clearance of oxipurinol, the chief metabolite of allopurinol. Am J Med 45:69–77, 1968.

    Article  PubMed  CAS  Google Scholar 

  50. Kantor G: Toxic epidermal necrolysis, azotemia, and death after allopurinol therapy. JAMA 212:478–479, 1970.

    Article  PubMed  CAS  Google Scholar 

  51. Simmonds HA, Cameron JS, Morris GS, Davies PM: Allopurinol in renal failure and the tumour lysis syndrome. Clin Chim Acta 160:189–195, 1986.

    Article  PubMed  CAS  Google Scholar 

  52. Al-Kawas FH, Seeff LB, Berendson RA, Zimmerman HJ, Ishak KG: Ann Intern Med 95:588–590, 1981.

    PubMed  CAS  Google Scholar 

  53. Utsinger P: Allopurinol hypersensitivity: Granular deposition of IgM at the dermal-epidermal junction. Am J Med 61:287–294, 1976.

    Article  PubMed  CAS  Google Scholar 

  54. Hande K, Reed E, Chabner B: Allopurinol kinetics. Clin Pharm Ther 23:598–605, 1978.

    CAS  Google Scholar 

  55. Appelbaum SJ, Mayersohn M, Dorr RT, Perrier D: Allopurinol kinetics and bioavailability. Cancer Chemother Pharmacol 8:93–98, 1982.

    Article  PubMed  CAS  Google Scholar 

  56. Berlinger WG, Park GD, Spector R: The effect of dietary protein on the clearance of allopurinol and oxypurinol. N Engl J Med 313:771–776, 1985.

    Article  PubMed  CAS  Google Scholar 

  57. Friedman H, Grasela T: Adenine arabinoside and allopurinol: Possible adverse drug interaction. N Engl J Med 304:423, 1981.

    Article  PubMed  CAS  Google Scholar 

  58. Kjellstrand CM, Campbell DC, von Haritzsch B, Buselmeier TJ: Hyperuricemic acute renal failure. Arch Intern Med 133;349–359, 1974.

    Article  PubMed  CAS  Google Scholar 

  59. Steinberg SM, Galen MM, Lazarus JM, Lowrie EG, Hampers CL, Jaffe N: Hemodialysis for acute anuric uric acid nephropathy. Am J Dis Child 130:956–958, 1975.

    Google Scholar 

  60. Maher JF, Ruth CE, Schreiner GE: Hyperuricemia complicating leukemia. Arch Intern Med 123:198–200, 1969.

    Article  PubMed  CAS  Google Scholar 

  61. Deger G. Waggoner R: Peritoneal dialysis in acute uric acid nephropathy. Mayo Clin Proc 47:189–192, 1972.

    PubMed  CAS  Google Scholar 

  62. Greger R, Lang F, Deetjen P: Handling of allantoin by the rat kidney, clearance and micropuncture data. Pflügers Arch 357:201–207, 1975.

    Article  CAS  Google Scholar 

  63. Zittoon R, Dauchy F, Teillaud C, Barthelemy M, Bouchard P: Le traitment des hyperuricémies en hématologie par l’unst-oxydase et l’allopurinol. Ann Med Interne 127:479–482, 1976.

    Google Scholar 

  64. Feuillu A, Herve JP, Pogamp PL, Garre M, Chevet D: Traitement de l’hyperuricémie secondaire de i’insuffisance rénale chronique per uricolyse enzymatique. Thérapie 35: 734–749, 1980.

    Google Scholar 

  65. Brogard JM, Stahl A, Stahl J: Enzymatic uricolysis and its use in therapy. In: WN Kelly, IM Weiner, eds, Uric Acid, Handbook of Experimental Pharmacology, Vol 51. Springer-Verlag, Berlin, pp 515–524, 1978.

    Google Scholar 

  66. Abuchowski A, Karp D, Davis FF: Reduction of plasma urate levels in the cokerel with polyethylene glycol-uricase. J Pharmacol Exp Ther 219:352–354, 1981.

    PubMed  CAS  Google Scholar 

  67. Davis S, Park YK: Hypouricaemic effect of polyethylene glycol modified urate oxidase. Lancet 2:281–283, 1981.

    Article  PubMed  CAS  Google Scholar 

  68. Fitzgerlad RH, Wallace KM, Baker A: Acute obstructive uric acid nephropathy after treatment of neoplastic adenopathy. South Med J 74:424–426, 1981.

    Article  Google Scholar 

  69. Bedrna J, Polcak J: Alcuter harnleiter verschluss nach bestrahlung chronischer leukämien mit röntgenstrahlen. Med Klin 25:1700–1701, 1929.

    Google Scholar 

  70. Kravitz SC, Diamond HD, Craver LF: Uremia complicating leukemia chemotherapy. JAMA 146:1595–1597, 1951.

    CAS  Google Scholar 

  71. Eason AA, Sharlip ID, Spaulding JT: Dissolution of bilateral uric acid calculi causing anuria. JAMA 240:670–671, 1978.

    Article  PubMed  CAS  Google Scholar 

  72. Simmonds HA, Warren DJ, Cameron JS, Potter CF, Farebrother DA: Familial gout and renal failure in young women. Clin Nephrol 14;176–182, 1980.

    PubMed  CAS  Google Scholar 

  73. Coe FL: Nephrolithiasis Pathogenesis and Treatment. Yearbook Medical Publishers, Chicago, pp 95–115, 1978.

    Google Scholar 

  74. Simkin PA, Hoover PL, Paxson CS, Wilson WF: Uric acid excretion: Quantitative assessment from spot, midmorning serum and urine samples. Ann Intern Med 91:44–47, 1979.

    PubMed  CAS  Google Scholar 

  75. Wortmann RL, Fox IH: Limited value of uric acid to creatinine ratios in estimating acid excretion. Ann Intern Med 93:822–825, 1980.

    PubMed  CAS  Google Scholar 

  76. Rieselbach RE, Sorensen LB, Shelp WD, Steele TH: Diminished renal urate secretion per nephron as a basis for primary gout. Ann Intern Med 73:359–366, 1970.

    PubMed  CAS  Google Scholar 

  77. Steele TH, Boner G: Origins of the uricosuric response. J Clin Invest 51:1368–1375, 1973.

    Article  Google Scholar 

  78. Jacobs DR: The coronary drug project research group: Serum uric acid: Its association with other risk factors and with mortality in coronary heart disease. J Chron Dis 29: 557–569, 1976.

    Article  Google Scholar 

  79. Viozzi FJ, Bluhm GB, Riddle JM: Gout and arterial thrombosis. Henry Ford Med J 20:119–214, 1972.

    Google Scholar 

  80. Talbott JH, Terplan KL: The kidney in gout. Medicine 38:405–462, 1960.

    Google Scholar 

  81. Barlow K, Beilin L: Renal disease in primary gout. J Med 37:79–98, 1968.

    CAS  Google Scholar 

  82. Modern F, Meister L: The kidney of gout, a clinical entity. Med Clin North Am 36:941–952, 1952.

    Google Scholar 

  83. Linnane J, Barry A, Emmerson B: Urate deposits in the renal medulla. Nephron 29:216–222, 1981.

    Article  PubMed  CAS  Google Scholar 

  84. Yü T-F: Cystic diseases of the kidney and gout. Arch Intern Med 138:1609, 1978.

    Article  PubMed  Google Scholar 

  85. Thompson GR, Weiss JJ, Goldman RT, Rigg GA: Familial occurrence of hyperuricemia, gout and medullary cystic disease. Arch Intern Med 138:1614–1617, 1978.

    Article  PubMed  CAS  Google Scholar 

  86. Yü T-F, Berger L. Impaired renal function in gout, its association with hypertensive vascular disease and intrinsic renal disease. Am J Med 72:95–100, 1982.

    Article  PubMed  Google Scholar 

  87. Campion E, Glynn R, Delabry M. Asymptomatic hyperuricemia. Risks and consequences in the normative aging study. Am J Med 82:421–426, 1987.

    Article  PubMed  CAS  Google Scholar 

  88. Brand F, McGee D, Kannel W, Stokes J, Castell W. Hyperuricemia as a risk factor of coronary heart disease: The Framingham Study. Am J Epid 121:11–18, 1985.

    CAS  Google Scholar 

  89. Reunanen A, Takkunen H, Knekt P, Aromaa A. Hyperuricemia as a risk factor for cardiovascular mortality. Acta Med Scand 668(Suppl):49–59, 1982.

    CAS  Google Scholar 

  90. Massari P, Usa C, Barnes R, Poxigikas P, Weller J. Familial hyperuricemia and renal disease. Arch Intern Med 140: 680–684, 1980.

    Article  PubMed  CAS  Google Scholar 

  91. Richmond J, Kincaid-Smith P, Whitworth J, Becker G. Familial gout and renal failure. Arch Dis Child 56:699–704, 1981.

    Article  Google Scholar 

  92. Foley RJ, Weinman EJ: Review: Urate nephropathy. Am J Med Sci 288:208–211, 1984.

    Article  PubMed  CAS  Google Scholar 

  93. Kelley WN: Pharmacologic approach to the maintenance of urate homeostasis. Nephron 14:99–115, 1975.

    Article  PubMed  CAS  Google Scholar 

  94. Gutman AB: Uricosuric drugs, with special reference to probenecid and sulfinpyrazone. Adv Pharmacol Chemother 4:91–142, 1966.

    Article  CAS  Google Scholar 

  95. Reese OG Jr, Steele TH: Renal transport of urate during diuretic-induced hypouricemia. Am J Med 60:973–979, 1976.

    Article  PubMed  CAS  Google Scholar 

  96. Wallace SL, Ertel NH: Pharmacology of drugs used in treatment of acute gout. In: WN Kelley, IM Weiner, eds, Uric Acid, Handbook of Experimental Pharmacology, Vol 51. Springer-Verlag, Berlin, pp 525–556, 1978.

    Google Scholar 

  97. Kuncl RW, Duncan G, Watson D, Alderson K, Rogawski MA, Peper M: Colchicine myopathy and neuropathy. N Engl J Med 316:1562–1568, 1987.

    Article  PubMed  CAS  Google Scholar 

  98. Steele TH: Diuretic-induced-induced hyperuricacemia. In: WN Kelley, ed, Crystal-Induced Arthropathies. Clinics in Rheumatic Diseases. Saunders, London, pp 37–50, 1977.

    Google Scholar 

  99. Manuel MA, Steele TH: Changes in renal urate handling after prolonged thiazide treatment. Am J Med 57:741–746, 1974.

    Article  PubMed  CAS  Google Scholar 

  100. Hall AP, Barry PE, Dawber TR, McNamara PM: Epidemiology of gout and hyperuricemia: A long-term population study. Am J Med 42:27–37, 1967.

    Article  PubMed  CAS  Google Scholar 

  101. Fessel WJ, Siegelaub AB, Johnson ES: Correlates and consequences of asymptomatic hyperuricemia. Arch Intern Med 132:44–54, 1973.

    Article  PubMed  CAS  Google Scholar 

  102. Fessel WJ: High uric acid as an indicator of cardiovascular disease. Independence from obesity. Am J Med 68:401–404, 1980.

    Article  PubMed  CAS  Google Scholar 

  103. Cannon PJ, Symchych PS, DeMartini FE: The distribution of urate in human and primate kidney. Proc Soc Exp Biol Med 129:278–285, 1968.

    PubMed  CAS  Google Scholar 

  104. Verger D, Leroux-Robert C, Ganter P, Richet G: Les tophus goutteux de la medullaire rénale des urémiques chroniques. Nephron 4:356–370, 1967.

    Article  PubMed  CAS  Google Scholar 

  105. Östberg Y: Renal urate deposits in chronic renal insufficiency. Acta Med Scand 183:197–201, 1968.

    Article  PubMed  Google Scholar 

  106. Fessel WJ: Renal outcomes of gout and hyperuricemia. Am J Med 67:74–82, 1979.

    Article  PubMed  CAS  Google Scholar 

  107. Yü T-F, Berger L: Renal disease in primary gout: A study of 253 gout patients with proteinuria. Semin Arthritis Rheum 4:293–305, 1975.

    Article  PubMed  Google Scholar 

  108. Berger L, Yü T-F: Renal function in gout: IV. An analysis of 525 gouty subjects including long-term follow-up studies. Am J Med 59:605–613, 1975.

    Article  PubMed  CAS  Google Scholar 

  109. Liang MH, Fries JF: Asymptomatic hyperuricemia: The case for conservative management. Ann Intern Med 88:666–670, 1978.

    PubMed  CAS  Google Scholar 

  110. Kelley W, Fox I. Gout and related disorders of purine metabolism. In: W Kelley, E Harris, S Ruddy, C Sledge, ed, Textbook of Rheumatology, 2nd. WB Saunders, Philadelphia pp 1359–1358, 1985.

    Google Scholar 

  111. Loeb JN: The influence of temperature on the solubility of monosodium urate. Arthritis Rheum 15:189–192, 1972.

    Article  PubMed  CAS  Google Scholar 

  112. Smilo RP, Beisel WR, Forsham PH: Reversal of thiazide-induced transient hyperuricemia by uricosuric agents. N Engl J Med 267:1225–1227, 1962.

    Article  PubMed  CAS  Google Scholar 

  113. Smith WE, Steele TH: The hyperuricemic nephropathies. In: WN Suki, SG Massry, eds, Therapy of Renal Diseases and Related Disorders, 1st ed. Martinus Nijhoff, Boston, pp 327–333, 1984.

    Google Scholar 

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Ahrens, E.R., Steele, T.H. (1991). Hyperuricemic Nephropathy. In: Suki, W.N., Massry, S.G. (eds) Therapy of Renal Diseases and Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0689-4_31

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