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Mixed Acid-Base Disorders

  • John T. Harrington
  • Nicolaos E. Madias

Abstract

Virtually all recent discussions of the diagnosis and management of mixed acid-base disturbances have focused exclusively on the acid-base disorders per se and have relegated the patient and the clinical setting to a subordinate position. In the 1980s several excellent reviews utilizing primarily a laboratory approach have appeared (1–3). In this laboratory-dominated approach, the acid-base data first are examined to determine whether they are consistent with any of the simple acid-base disorders; if the acid-base data do not fit, and assuming that they reflect a steady state, one can confidently conclude that a mixed acid-base disturbance is present (4). For instance, in a patient with a plasma bicarbonate concentration of 8mEq/l, the finding of a PaCO2 level substantially greater than the value anticipated for simple metabolic acidosis establishes the presence of a concomitant element of respiratory acidosis and thus the presence of a mixed acid-base disorder.

Keywords

Metabolic Acidosis Lactic Acidosis Metabolic Alkalosis Respiratory Acidosis Respiratory Alkalosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • John T. Harrington
  • Nicolaos E. Madias

There are no affiliations available

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