Abstract
Human retrotransposons, the Alu-family DNA repeats (AFRs), are members of an abundant heterogeneous family of short intersperced repeats containing promoter for RNA polymerase III, which is active in vitro (Perez-Stable et al., 1984) but is silent in HeLa cells in vivo (Poulson and Schmid, 1986). We have studied long-range distribution of AFRs in human chromosomes using tritium-labeled (Filatov et al., 1984; Filatov et al., 1987; Filatov et al., 1988) and biotin-labeled Alu-probes and have found that the distribution is non-random: some chromosome bands reproducibly show a more intensive hybridization signal compared to other bands.
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© 1990 Plenum Press, New York
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Filatov, L.V., Mamayeva, S.E., Tomilin, N.V. (1990). Non-Random Distribution of Alu-Family DNA Repeats in Human Chromosomes. In: Harris, J.R., Zbarsky, I.B. (eds) Nuclear Structure and Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0667-2_9
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DOI: https://doi.org/10.1007/978-1-4613-0667-2_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-7918-1
Online ISBN: 978-1-4613-0667-2
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