Abstract
It is now established that histones are essentially structural components of chromatin. In particular, histones H2A, H2B, H3 and H4 spontaneously form octamers, around which a DNA molecule can wind. Such histone octamer-DNA complex constitues a nucleosome (for review, see Kornberg, 1977). This structural organization seems to be characteristic for packaging DNA in the inactive non-transcribed from of chromatin, whereas active genes are apparently compacted in an altered nucleosome structure (for review, see Reeves, 1984). Further, in the case of extremely active genes, such as the ribosomal genes, the presence of histones even remains a matter of much discussion.
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Kornberg R. 1977, Structure of chromatin, Annu. Rev. Biochem., 46:931.
Reeves R. 1984, Transcriptionally active chromatin, Biochim. Biophys. Acta, 782:343.
Thiry M. 1988, Immunoelectron microscope localization of bromodeoxyuridine incorporated into DNA of Ehrlich tumor cell nucleoli, Exp. Cell Res., 179:204.
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© 1990 Plenum Press, New York
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Thiry, M. (1990). Spatial Distribution of DNA and Histones within Ehrlich Tumor Cell Nuclei by Immunoelectron Microscopy. In: Harris, J.R., Zbarsky, I.B. (eds) Nuclear Structure and Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0667-2_35
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DOI: https://doi.org/10.1007/978-1-4613-0667-2_35
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