Abstract
The most immediate question that must be answered to further our understanding of nucleoli is; “In which component are the actively transcribing genes?” The conclusion reached from the early studies employing the spreading technique and also autoradiography was that the active genes were in the dense fibrillar component. This interpretation has been seriously challenged by the newer approaches of EM immuno-gold localization (Scheer and Rose, 1984; Thiry et al. 1988). These later studies have shown the presence of polymerase I and DNA in the fibrillar centres but have failed to show them in the dense fibrillar component. It has been argued from this that there is no DNA or transcription in the dense fibrillar component.
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© 1990 Plenum Press, New York
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Jordan, E.G., Rawlins, D.J. (1990). Nucleolar DNA Distribution and Its Consequences for the Interpretation of Nucleolar Components. In: Harris, J.R., Zbarsky, I.B. (eds) Nuclear Structure and Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0667-2_30
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DOI: https://doi.org/10.1007/978-1-4613-0667-2_30
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-7918-1
Online ISBN: 978-1-4613-0667-2
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