In Search of the Etiology of Alzheimer’s Disease

  • John A. Edwards
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 282)


Alzheimer’s disease is defined by a characteristic neuropathology consisting of neurofibrillary tangles made up of intraneuronal paired helical filaments and straight filaments, and senile plaques made up of a core of extracellular amyloid fibrils surrounded by dystrophic neurites and glial cells, the accumulation of the same amyloid fibrils in cerebral and meningeal microvessels and loss of neurones. This neuropathology predominantly affects the frontal, parietal and temporal cortex, and hippocampus.


Neurofibrillary Tangle Senile Plaque Amyloid Fibril Paired Helical Filament Late Onset Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • John A. Edwards
    • 1
  1. 1.Departments of Medicine and Family MedicineState University of New York at BuffaloBuffaloUSA

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