Emestrin, a New Mycotoxin, Introduced Injuries in Various Organs of Mice
Emestrin (EMS) is an epidithiodioxopiperazine mycotoxin first described as a metabolite of Emericella striata 6 (Fig. 1). EQ-1 named by Maebayashi et al.3 for a toxic metabolite of E. quadrilineata and E. paravathecia was identified as EMS by Seya et al.6 Species of the genus Emericella are disibuted widely throughout tropical and subtropical countries. EMS-producing species have been isolated from various speices imported into Japan from several counries in Asia.7 In contrast to chemical studies and surveillance of food-born EMS-producing fungi, only limited information is available regarding the biological activities of EMS. In an in vitro system, K. Ishizaki and K. Kawai2 observed potent suppressive effects of EMS on the respiratory system in mitochondria. In an in vivo system, however, no precise toxicological studies have been reported regarding the target organs of experimental animals after administration of EMS. Our present study was undertaken to investigate the morphological changes in the target organs of mice after the administration of EMS.
KeywordsToxicity Leukemia Peri Tral Ribo
Unable to display preview. Download preview PDF.
- 1.Carlton WW, Scech GM, 1977, Mycotoxicosis in laboratory animals, In: “Mycotoxic Fungi, Mycotoxins, Mycotoxicosis, Vol. 3”, Wyllie TD, Morehouse LG, eds., Marcel Dekker, New York.Google Scholar
- 2.Ishizaki K, Kawai K, Kawai K, 1988,The effect of emestrin from Emericell straita on mitochondrial reaction, In: Symposiom-“7th International symposium on mycotoxins and phycotoxins,” August 16–19, 1988 Tokyo (Abstract)Google Scholar
- 3.Maebayashi Y, Horie Y, Yamazaki M, 1984, Productivity of some mycotoxins in fungi isolated from Iraqi soil, Prod Jpn Soc Mycotoxicol., 20:28–30.Google Scholar
- 4.Nagarajan R, 1984, Gliotoxin and epipolythiodioxopiperazines, In: “Mycotoxins, Production, Isolation, Separation and Purification”, Betin V., ed., Elsevier, New York.Google Scholar
- 5.Saito T, Suzuki Y, Koyama K, Natori S, Iitaka Y, Kinoshita K, 1988, Chetracin A and Chaetocins B and C, three new epipolythiodioxopiperazines from ö., Chem Pharm Bull., 36:1942–1956.Google Scholar
- 6.Seya H, Nakajima S, Kawai K, Udagawa S, 1985, Structure and absolute configuration of emestrin, a new macrocyclic epidithiodioxopiperazine from Emericella striata, J Chem Soc Chem Commun.,:657–658.Google Scholar
- 7.Udagawa S, 1986, Fungal contamination of imported spices, with special reference to ascomycetous fungi, Jpn J Food Microbiol., 3:46–52.Google Scholar