The Immunosuppressive Action of Gliotoxin and Related Epipolythiodioxopipderazines

  • Arno Mullbacher
  • Ronald D. Eichner
  • Paul Waring


The epipolythiodioxopiperazines (ETP) including gliotoxin (GT) are a class of secondary fungal metabolites with a bridged polysulfide ring structure as their common distinctive feature (Figure 1). Early studies of these unusual compounds concentrated on their anti-microbial properties and possible anti-tumor activities. These early studies have been extensively reviewed.14,16


Graft Rejection Carbonyl Iron Opportunistic Fungal Infection Secondary Fungal Metabolite Immune Induction 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Arno Mullbacher
    • 1
  • Ronald D. Eichner
    • 1
  • Paul Waring
    • 1
  1. 1.Division of Virology and Cellular Pathology, John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

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