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The Immunosuppressive Action of Gliotoxin and Related Epipolythiodioxopipderazines

  • Arno Mullbacher
  • Ronald D. Eichner
  • Paul Waring

Abstract

The epipolythiodioxopiperazines (ETP) including gliotoxin (GT) are a class of secondary fungal metabolites with a bridged polysulfide ring structure as their common distinctive feature (Figure 1). Early studies of these unusual compounds concentrated on their anti-microbial properties and possible anti-tumor activities. These early studies have been extensively reviewed.14,16

Keywords

Graft Rejection Carbonyl Iron Opportunistic Fungal Infection Secondary Fungal Metabolite Immune Induction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Arno Mullbacher
    • 1
  • Ronald D. Eichner
    • 1
  • Paul Waring
    • 1
  1. 1.Division of Virology and Cellular Pathology, John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

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