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ADP-Ribosylation of Actin by Clostridial Toxins

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Microbial Toxins in Foods and Feeds

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Abstract

ADP-rlbosylation of regulatory proteins is an important mechanism by which bacterial toxins affect the eukaryotic organism.9,27,32 Diphtheria toxin and Pseudomonas aeruginosa exotoxin A modify elongation factor 2 thereby inhibiting protein synthesis.9,26,32 Cholera toxin, Escherichia coli heat-labile enterotoxin and pertussis toxin ADP-ribosylate regulatory G-proteins involved in a variety of transmembranous signaling processes in eukaryotic cells.8,9,28,32 These G-proteins (Gg, Gi, Go, transducin) comprise a family of highly homologous proteins of heterotrimeric structure,25 which function by utilizing a guanine nucleotide binding and GTPase cycle. The toxins ADP-ribosylate the α-subunit of the G-proteins thereby either enhancing (cholera toxin) or inhibiting (pertussis toxin) signal transduction.25

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Authors and Affiliations

  1. Rudolf-Buchheim-Institut fur Pharmakologie der Universitat Gießen, Frankfurter Str. 107, D-6300, Gießen, Germany

    Klaus Aktories, Udo Geipel, Monika Laux & Ingo Just

Authors
  1. Klaus Aktories
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  2. Udo Geipel
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  3. Monika Laux
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  4. Ingo Just
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Editor information

Editors and Affiliations

  1. Food and Drug Administration, Washington, DC, USA

    Albert E. Pohland

  2. Late of Centers for Disease Control, Atlanta, Georgia, USA

    Vulus R. Dowell Jr.

  3. Agricultural Research Service, Peoria, Illinois, USA

    John L. Richard

  4. Agricultural Research Service, Dawson, Georgia, USA

    Richard J. Cole

  5. National Marine Fisheries Service, Seattle, Washington, USA

    Milven W. Eklund

  6. Food Safety and Inspection Service, Washington, DC, USA

    Stanley S. Green

  7. Agricultural Research Service, Athens, Georgia, USA

    William P. Norred III

  8. Centers for Disease Control, Atlanta, Georgia, USA

    Morris E. Potter

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© 1990 Plenum Press, New York

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Aktories, K., Geipel, U., Laux, M., Just, I. (1990). ADP-Ribosylation of Actin by Clostridial Toxins. In: Pohland, A.E., et al. Microbial Toxins in Foods and Feeds. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0663-4_3

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  • DOI: https://doi.org/10.1007/978-1-4613-0663-4_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7916-7

  • Online ISBN: 978-1-4613-0663-4

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