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Use of Aflatoxin-DNA and Protein Adducts for Human Dosimetry

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Abstract

The last twenty-five years has seen extensive efforts to investigate the association between aflatoxin exposure and human liver cancer. Studies using standard epidemiological methods have been hindered by the lack of adequate dosimetry data on aflatoxin intake, excretion and metabolism, as well as by the general poor quality of world-wide cancer morbidity and mortality statistics. Despite these difficulties, the aflatoxins are among the few strucrally identified environmental carcinogens for which quantitative risk assessments have been attempted. These efforts have spurred a number of investitors, in the last few years, to develop reliable, fast and accurate techniques to assess individual human exposure to this carcinogen.

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References

  1. Bosch FX, Munoz N, 1988, Prospects for epidemiological studies on hepatocellular cancer as a model for assessing viral and chemical interactions. IARC Sci Publ., 89:427–438.

    Google Scholar 

  2. Bulatao-Jayme J, Almero EM, Castaro CA, Jardeleza TR, Salamat L, 1982, A case-control dietary study of primary liver cancer risk from aflatoxin exposure, Intnl J Epidemiol., 11(2):112–119.

    Article  CAS  Google Scholar 

  3. Busby WF, Wogan GN, 1985, Aflatoxins, In: “Chemical Carcinogens,” Searle CE, ed., American Chemical Society, Washington, DC.

    Google Scholar 

  4. Croy RG, Essigmann JM, Reinhold VN, Wogan GN, 1978, Identification of the principle aflatoxin Bl-DNA adduct formed in vivo in rat liver, Proc Natl Acad Sci USA, 75:1745–1749.

    Article  CAS  Google Scholar 

  5. Essigman JM, Croy RG, Nadzan AM, Busby WF, Reinhold VN, Buchi G, Wogan GN, 1977, Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro, Proc Natl Acad Sci USA, 74:1870–1874.

    Article  Google Scholar 

  6. Gan LS, Skipper PL, Peng XC, Groopman JD, Chen JS, Wogan GN, Tannenbaum SR, 1988, Serum albumin adducts in the molecular epidemiology of aflatoxin carcinogenesis: correlation with aflatoxin B1 intake and urinary excretion of aflatoxin M, Carcinogenesis, 9:1323–1325.

    Article  CAS  Google Scholar 

  7. Groopman JD, Donahue PR, Zhu J, Chen J, Wogan GN, 1985, Aflatoxin metabolism in humans: Detection of metabolites and nucleic acid adducts in urine by affinity chromatography, Proc Natl Acad Sci USA, 82:6492–6497.

    Article  CAS  Google Scholar 

  8. Groopman JD, Busby WF, Donahue PR, Wogan GN, 1986, Aflatoxins as risk factors for liver cancer: an application of monoclonal antibodies to monitor human exposure, In: “Biochemical and Molecular Epidemiology of Cancer,” Harris, CC, ed., Alan R. Liss, Inc., New York.

    Google Scholar 

  9. Groopman JD, Donahue PR, Zhu J, Chen J, Wogan GN, 1987, Temporal patterns of aflatoxin metabolites in urine of people living in Guangxi Province, P.R.C., Proc Amer Assoc Cancer Res., 28:36.

    Google Scholar 

  10. Groopman JD, Cain LG, Kensler TW, 1988, Aflatoxin exposure in human populations: Measurements and relationships to cancer, CRC Critical Reviews in Toxicology, 19:113–145.

    Article  CAS  Google Scholar 

  11. Hertzog PJ, Lindsay-Smith JR, Garner RC, 1982, Production of monoclonal antibodies to guanine imidazole ring-opened aflatoxin B1 - DNA, the persistent DNA adduct in vivo, Carcinogenesis, 3:723–725.

    Article  CAS  Google Scholar 

  12. Lin JK, Miller JA, Miller EC, 1977, 2,3-Dihydro-2-(guan-7-yl)-3-hydroxy aflatoxin B, a major acid hydrolysis product of aflatoxin B1 DNA or -ribosomal RNA adducts formed in hepatic microsome mediated reactions in rat liver in vivo, Cancer Res., 37:4430–4438.

    CAS  Google Scholar 

  13. National Cancer Office of the Ministry of Public Health, P.R.C., 1980, In: “Studies on Mortality Rates of Cancer in China,” People’s Publishing House, Beijing.

    Google Scholar 

  14. Peers F, Bosch X, Kaldor J, Linsell A, Pluijmen M, 1987, Aflatoxin expos ure, hepatitis B virus infection and liver cancer in Swaziland, Intnl J Cancer, 39:545–553.

    Article  CAS  Google Scholar 

  15. Sabbioni G, Skipper P, Buchi G, Tannenbaum SR, 1987, Isolation and characterization of the major serum albumin adduct formed by aflatoxin B in vivo in rats, Carcinogenesis, 8:819–824.

    Article  CAS  Google Scholar 

  16. Shimada T, Guengerich FP, 1989, Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactiva- tion of aflatoxins in human liver, Proc Natl Acad Sci USA, 86:462–465.

    Article  CAS  Google Scholar 

  17. Van Rensburg SF, Cook-Mozaffari P, Van Schalkwyk DJ, Van der Watt JJ, Vincent TJ, Purchase IF, 1985, Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei, Br J Cancer, 51:713–726.

    Article  Google Scholar 

  18. Yeh FS, Shen KN, 1986, Epidemiology and early diagnosis of primary liver cancer in China, Adv in Cancer Res., 47:297–329.

    Article  Google Scholar 

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© 1990 Plenum Press, New York

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Groopman, J.D. (1990). Use of Aflatoxin-DNA and Protein Adducts for Human Dosimetry. In: Pohland, A.E., et al. Microbial Toxins in Foods and Feeds. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0663-4_29

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  • DOI: https://doi.org/10.1007/978-1-4613-0663-4_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7916-7

  • Online ISBN: 978-1-4613-0663-4

  • eBook Packages: Springer Book Archive

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