Immunological Aspects of Candidosis in AIDS Patients

  • David W. Warnock


Candida albicans, the most common cause of human candidosis, is found as a commensal in the mouth and gastrointestinal tract of a substantial proportion of the normal population. This opportunist pathogen can cause deep-seated infection, which can be localized or disseminated, in immunosuppressed or debilitated individuals, but is more often seen causing superficial cutaneous or mucosal infection.


Candida Albicans Acquire Immunodeficiency Syndrome Human Immune Deficiency Virus Systemic Candidiasis Chronic Mucocutaneous Candidiasis 
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  1. Becker, J., Ulrich, P., Kunze, R., Gelderblom, H., Langford, A., and Reichart, P., 1988, Immunohistochemical detection of HIV structural proteins and distribution of T-lymphocytes and Langerhans cells in the oral mucosa of HIV infected patients, Virchows Arch. [A], 412:413.CrossRefGoogle Scholar
  2. Belsito, D.V., Sanchez, M.R., Baer, R.L., Valentine, F., and Thorbecke, G.J., 1984, Reduced Langerhans cell Ia antigen and ATPase activity in patients with the acquired immunodeficiency syndrome, N. Engl. J. Med., 310:1279.PubMedCrossRefGoogle Scholar
  3. Bender, B.S., Davidson, B.L., Kline, R., Brown, C., and Quinn, T.C., 1988, Role of the mononuclear phagocyte system in the immunopathogenesis of human immunodeficiency virus infection and the acquired immunodeficiency syndrome, Rev. Infect. Dis., 10:1142.PubMedCrossRefGoogle Scholar
  4. Bienenstock, J., and Befus, A.D., 1980, Mucosal immunology, Immunology 41:249.PubMedGoogle Scholar
  5. Budhraja, M., Levendoglu, H., Kocka, F., Mangkornkanok, M., and Sherer, R., 1987, Duodenal mucosal T-cell subpopulation and bacterial cultures in acquired immunodeficiency syndrome, Am. J. Gastroenterol., 82:427.PubMedGoogle Scholar
  6. Carpenter, C.C.J., Mayer, K.H., Fisher, A., Desai, M.B., and Durand, L., 1989, Natural history of acquired immunodeficiency syndrome in women in Rhode Island, Am. J. Med., 86:771.PubMedCrossRefGoogle Scholar
  7. Diamond, R.D., Krzesicki, R., and Jao, W., 1978, Damage to pseudohyphal forms of Candida albicans by neutrophils in the absence of serum in vitro, J, Clin. Invest., 61:349.CrossRefGoogle Scholar
  8. Diamond, R.D., Clark, R.A., and Haudenschild, C.C., 1980, Damage to Candida albicans hyphae and pseudohyphae by the myeloperoxidase system and oxidative products of neutrophil metabolism in vivo, J. Clin. Invest., 66:908.PubMedCrossRefGoogle Scholar
  9. Djawari, D., Bischoff, T., and Hornstein, O.P., 1977, Defect of phagocytosis and intracellular killing of Candida albicans by granulocytes in patients with familiar and non-familiar chronic mucocutaneous candidosis, Arch. Dermatol. Res., 260:159.PubMedCrossRefGoogle Scholar
  10. Domer, J., Elkins, K., Ennist, D., and Baker, P., 1988, Modulation of immune responses by surface polysaccharides of Candida albicans, Rev. Infect. Dis., 10(2):S419.PubMedGoogle Scholar
  11. Ellis, M., Gupta, S., Galant, S., Hakim, S., VandeVen, C., Toy, C., and Cairo, M.S., 1988, Impaired neutrophil function in patients with AIDS or AIDS-related complex: comprehensive evaluation, J. Infect. Dis., 158:1268.PubMedCrossRefGoogle Scholar
  12. Epstein, J.B., Kimura, L.H., Menard, T.W., Truelove, E.L., and Pearsall, N.N., 1982, Effects of specific antibodies on the interaction between the fungus Candida albicans and human oral mucosa, Arch. Oral Biol., 27:469.PubMedCrossRefGoogle Scholar
  13. Estevez, M.E., Ballart, I.J., Diez, R.A., Planes, N., Scaglione, C., and Sen, L., 1986, Early defect of phagocytic cell function in subjects at risk for acquired immunodeficiency syndrome, Scand. J. Immunol., 24:215.PubMedCrossRefGoogle Scholar
  14. Fischer, A., Ballett, J.J., and Griscelli, C., 1978, Specific inhibition of in vitro Candida induced lymphocyte proliferation by polysaccharide antigens present in the serum of patients with chronic mucocutaneous candidiasis, J. Clin. Invest., 62:1005.PubMedCrossRefGoogle Scholar
  15. Fischer, A., Pichat, L., Audinot, M., and Griscelli, C., 1982, Defective handling of mannan by monocytes in patients with chronic mucocutaneous candidiasis resulting in a specific cellular unresponsiveness, Clin. Exp. Immunol., 47:653.PubMedGoogle Scholar
  16. Gough, P.M., Warnock, D.W., Richardson, M.D., Mansell, N.J., and King, J.M., 1984, IgA and IgG antibodies to Candida albicans in the genital tract secretions of women with or without vaginal candidosis, Sabouraudia, 22:265.PubMedCrossRefGoogle Scholar
  17. Greenfield, R.A., and Jones, J.M., 1981, Purification and characterization of a major cytoplasmic antigen of Candida albicans, Infect. Immun., 34:469.PubMedGoogle Scholar
  18. Kirkpatrick, C.H., 1984, Host factors in defense against fungal infections, Am, J, Med., 77:1.Google Scholar
  19. Kirkpatrick, C.H., and Smith, T.K., 1974, Chronic mucocutaneous candidiasis. Immunologic and antibiotic therapy, Ann. Int. Med., 80:310.PubMedGoogle Scholar
  20. Klein, R.S., Harris, C.A., Butkus Small, C., Moll, B., Lesser, M., and Friedland, G.H., 1984, Oral candidiasis in high risk patients as the initial manifestation of the acquired immune deficiency syndrome. N. Engl. J. Med., 311:354.PubMedCrossRefGoogle Scholar
  21. Korting, H.C., Ollert, M., Georgii, A., and Froschl, M., 1988, In vitro susceptibilities and biotypes of Candida albicans isolates from the oral cavities of patients infected with human immunodeficiency virus, J. Clin. Microbiol., 26:2626.PubMedGoogle Scholar
  22. Kotier, D.P., Scholes, J.V., and Tierney, A.R., 1987, Intestinal plasma cell alterations in acquired immunodeficiency syndrome, Dig. Dis. Sci., 32:129.CrossRefGoogle Scholar
  23. Lamm, M.E., Roux, M.E., McWilliams, M., and Phillips-Quagliata, J.M., 1982, Differentiation and migration of mucosal plasma cell precursors, in: “Recent advances in mucosal immunity”, W. Strober, L.A. Hanson, K.W. Sell, eds., Raven Press, New York.Google Scholar
  24. Lane, H.C., and Fauci, A.S., 1985, Immunologic abnormalities in the acquired immunodeficiency syndrome, Ann. Rev. Immunol., 3:477.CrossRefGoogle Scholar
  25. Lazzarin, A., Uberti Foppa, C., Galli, M., Mantovani, A., Poli, G., Franzetti, F., and Novati, R., 1986, Impairment of polymorphonuclear leukocyte function in patients with acquired immunodeficiency syndrome and with lymphadenopathy syndrome, Clin. Exp. Immunol., 65:105.PubMedGoogle Scholar
  26. Lehner, T., Wilton, J.M.A., and Ivanyi, L., 1972, Immunodeficiencies in chronic mucocutaneous candidosis, Immunology, 22:775.PubMedGoogle Scholar
  27. Lehrer, R.I., 1970, Measurement of candidacidal activity of specific leukocyte types in mixed cell populations. I. Normal, myeloperoxidase-deficient and chronic granulomatous disease neutrophils, Infect. Immun., 2:42.PubMedGoogle Scholar
  28. Lehrer, R.I., 1972, Functional aspects of a second mechanism of candidacidal activity by human neutrophils, J. Clin. Invest., 51:2566.PubMedCrossRefGoogle Scholar
  29. Lehrer, R.I., and Cline, N.J., 1971, Leukocyte candidacidal activity and resistance to systemic candidiasis in patients with cancer, Cancer, 27:1211.PubMedCrossRefGoogle Scholar
  30. Levine, M.S., Woldenberg, R., Herlinger, H., and Laufer, I., 1987, Opportunistic esophagitis in AIDS: radiographic diagnosis, Radiology, 165:815.PubMedGoogle Scholar
  31. MacFarlane, T.W., and Mason, D.K., 1974, Changes in the oral flora in Sjogren’s syndrome, J. Clin. Pathol., 27:416.PubMedCrossRefGoogle Scholar
  32. Matthews, R.C., Burnie, J.P., and Tabaqchali, S., 1984, Immunoblot analysis of the serological response in systemic candidiasis, Lancet, 2:1415.PubMedCrossRefGoogle Scholar
  33. Matthews, R.C., Burnie, J.P., and Tabaqchali, S., 1987, Isolation of immunodominant antigens from sera of patients with systemic candidiasis and characterization of serological response to Candida albicans. J. Clin. Microbiol., 25:230.PubMedGoogle Scholar
  34. Matthews, R., Burnie, J., Smith, D., Clark, I., Midgley, J., Conolly, M., and Gazzard, B., 1988, Candida and AIDS: evidence for protective antibody, Lancet, 2:263.PubMedCrossRefGoogle Scholar
  35. McNabb, P., and Tornasi, T.B., 1981, Host defense mechanisms at mucosal surfaces, Ann. Rev. Microbiol., 35:477.CrossRefGoogle Scholar
  36. Melbye, M., Schonheyder, H., Kestens, L., Stenderup, A., Gigase, P.L., Ebbesen, P., and Biggar, R.J., 1985, Carriage of oral Candida albicans associated with a high number of circulating suppressor T lymphocytes, J. Infect. Dis., 152:1356.PubMedCrossRefGoogle Scholar
  37. Murphy, P.M., Lane, H.C., Fauci, A.S., and Gallin, J.I., 1988, Impairment of neutrophil bactericidal capacity in patients with AIDS, J. Infect. Dis., 158:627.PubMedCrossRefGoogle Scholar
  38. Nielsen, H., Kharazmi, A., and Faber, V., 1986, Blood monocyte and neutrophil functions in the acquired immune deficiency syndrome, Scand. J. Immunol., 24:291.PubMedCrossRefGoogle Scholar
  39. Paterson, P.Y., Semo, R., Blumenschein, G., and Swelstad, J., 1971, Mucocutaneous candidiasis, anergy and a plasma inhibitor of cellular immunity: reversal with amphotericin B, Clin. Exp. Immunol., 9:595.PubMedGoogle Scholar
  40. Poli, G., Bottazzi, B., Acero, R., Bersani, L., Rossi, V., Introna, M., Lazzarin, A., Galli, M., and Mantovani, A., 1985, Monocyte function in intravenous drug abusers with lymphadenopathy syndrome and in patients with acquired immunodeficiency syndrome: selective impairment of Chemotaxis, Clin. Exp. Immunol., 62:136.PubMedGoogle Scholar
  41. Rhoads, J.L., Wright, D.C., Redfield, R.R., and Burke, D.S., 1987, Chronic vaginal candidiasis in women with human immunodeficiency virus infection, JAMA, 257:3105.PubMedCrossRefGoogle Scholar
  42. Rodgers, V.D., Fassett, R., and Kagnoff, M.F., 1986, Abnormalities in intestinal mucosal T cells in homosexual populations including those with the lymphadenopathy syndrome and acquired immunodeficiency syndrome, Gastroenterology, 90:552.PubMedGoogle Scholar
  43. Schiodt, M., and Pindborg, J.J., 1987, AIDS and the oral cavity. Epidemiology and clinical oral manifestations of human immune deficiency virus infection: a review, Int. J. Maxillofac. Surg., 16:1.CrossRefGoogle Scholar
  44. Schonheyder, H., Melbye, M., Biggar, R.J., Ebbesen, P., Neuland, C.Y., and Stenderup, A., 1984, Oral yeast flora and antibodies to Candida albicans in homosexual men. Mykosen, 27:539.PubMedGoogle Scholar
  45. Schulten, E.A.J.M., ten Kate, R.W., and van der Waal, I., 1989, Oral manifestations of HIV infection in 75 Dutch patients, J. Oral Pathol. Med., 18:42.PubMedCrossRefGoogle Scholar
  46. Shannon, K., Cowan, M.J., Ball, E., Abrams, D., Volberding, P., and Ammann, A.J., 1985, Impaired mononuclear-cell proliferation in patients with the acquired immune deficiency syndrome results from abnormalities of both T lymphocytes and adherent mononuclear cells, J. Clin. Immunol., 5:239.PubMedCrossRefGoogle Scholar
  47. Silverman, S., Migliorati, C.A., Lozada-Nur, F., Greenspan, D., and Conant, M., 1986, Oral findings in people with or at high risk for AIDS: a study of 375 homosexual males, J. Am. Dent. Assoc., 112:187.PubMedGoogle Scholar
  48. Smith, P.D., Ohura, K., Masur, H., Lane, H.C., Fauci, A.S., and Wahl, S.M., 1984, Monocyte function in the acquired immune deficiency syndrome: defective Chemotaxis, J. Clin. Invest., 74:2121.PubMedCrossRefGoogle Scholar
  49. Strockbine, N.A., Largen, M.T., Zweibel, S.M., and Buckley, H.R., 1984, Identification and molecular weight characterization of antigens from Candida albicans that are recognized by human sera, Infect.Immun., 43:715.PubMedGoogle Scholar
  50. Tavitian, A., Raufman, J.P., and Rosenthal, L.F., 1986, Oral candidiasis in the acquired immunodeficiency syndrome, Ann. Int. Med., 104:54.PubMedGoogle Scholar
  51. Torssander, J., Morfeldt-Manson, L., Biberfeld, G., Karlsson, A., Putkonen, P.O., and Wasserman, J., 1987, Oral Candida albicans in HIV infection, Scand. J. Infect. Dis., 19:291.PubMedCrossRefGoogle Scholar
  52. Tsang, P.H., Sei, Y., and Bekesi, J.G., 1987, Isoprinosine-induced modulation of T-helper-cell subsets and antigen-presenting monocytes resulted in improvement of T-and B-lymphocyte functions, in vitro and in ARC and AIDS patients, Clin. Immunol. Immunopathol., 45:166.PubMedCrossRefGoogle Scholar
  53. Vudhichamnong, K., Walker, D.M., and Ryley, H.C., 1982, The effect of secretory immunoglobulin A on the in-vitro adherence of the yeast Candida albicans to human oral epithelial cells, Arch. Oral Biol., 27:617.PubMedCrossRefGoogle Scholar
  54. Weiner, M., and Coats-Stephen, M., 1979, Immunodiagnosis of systemic candidiasis: mannan antigenemia detected by radio-immunoassay in experimental and human infections, J. Infect. Dis., 140:989.PubMedCrossRefGoogle Scholar
  55. Williams, R.C., Gibbons, R.J., 1972, Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal, Science, 177:697.PubMedCrossRefGoogle Scholar
  56. Witkin, S.S., Hirsh, J., Ledger, W.J., 1986, A macrophage defect in women with recurrent-Candida vaginitis and its reversal in vitro by prostaglandin inhibitors, Am. J. Obstet. Gynecol., 155:790.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • David W. Warnock
    • 1
  1. 1.Department of MicrobiologyBristol Royal InfirmaryBristolUK

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