Doppler Ultrasound in Infertility
In previous publications I have reported that uterine response to endogenous hormonal changes in the spontaneous ovarian cycle can be demonstrated with use of doppler ultrasound techniques (Goswamy and Steptoe, 1988a and Goswamy et al., 1988b). We demonstrated that uterine perfusion increases in response to rising estrogen levels during the follicular phase, decreases in the preovulatory phase in response to the preovulatory estrogen fall, and increases in the luteal phase in response to the combined effect of estrogen and progesterone. We also reported that in conception cycles uterine perfusion continues to increase in the late luteal phase in contrast with non-conception cycles where there is premenstrual decrease in perfusion as a result of falling progesterone levels, thus postulating that doppler ultrasound techniques could be used to diagnose pregnancy prior to the date of expected onset of menses.
KeywordsPregnancy Rate Uterine Artery Late Luteal Phase Uterine Perfusion Doppler Ultrasound Technique
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- Goswamy, R.K., and Steptoe, P.C., 1988, Doppler ultrasound studies of the uterine artery in spontaneous ovarian cycles. Human Reprod. 3, 6:721–726.Google Scholar
- Goswamy, R.K., Williams, G., and Steptoe, P.C., 1988b, Decreased uterine perfusion — a cause of infertility, Human Reprod. 3, 8:955–959.Google Scholar
- Howies, C.M., Macnamee, M., Edwards, R.G., Goswamy, R.K., and Steptoe, P.C., 1986, The effect of high tonic levels of luteinizing hormone on outcome of in vitro fertilization, Lancet, ii:521–522.Google Scholar
- Steptoe, P.C., Edwards, R.G., and Walters, D.E., 1986, Observations 767 clinical pregnancies and 500 births after human in vitro fertilization, Human Reprod., 1:89–94.Google Scholar