Abstract
Although the central role of gonadotropins in the regulation of granulosa cell ontogeny is well established,1,2 the variable fate of ovarian follicles subjected to comparable gonadotropic stimulation suggests the existence of additional intraovarian modulatory mechanisms.1,3 In this connection, the role of several growth factors has been the subject of increasingly intense investigation.1 Among potential modulators of granulosa cell ontogeny, the insulin-like growth factors (IGFs) appear unlikely suited to the task, combining replicative and in some instances cytodifferentiative properties.1 On the other hand Somatomedin-C (Sm-C)/IGF-I seems to play an important role, not only in stimulating cell replication in tissues of diverse origin, but also in promoting the differentiation of different cell types.1 Somatomedin-C (Sm-C)/IGF-I displays stringent growth hormone (GH) dependence1,4,5 in vivo and in vitro.1,4
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References
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Blumenfeld, Z., Lunenfeld, B., Brandes, J.M. (1990). The Permissive Role of Growth Hormone in Ovulation Induction with Human Menopausal Gonadotropin. In: Mashiach, S., Ben-Rafael, Z., Laufer, N., Schenker, J.G. (eds) Advances in Assisted Reproductive Technologies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0645-0_45
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DOI: https://doi.org/10.1007/978-1-4613-0645-0_45
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