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Limitations in the Use of Combined Gonadotropin Releasing Hormone Analog and Human Menopausal Gonadotropin for In Vitro Fertilization

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Advances in Assisted Reproductive Technologies

Abstract

Ovarian stimulation is an important step in in vitro fertilization (IVF) therapy which has had a profound impact upon the success or failure of the whole procedure. It is now recognised that no single ovarian stimulation agent or dosage is optimal for all patients and that stimulation should be tailored and adjusted to best suit the patient’s own hormonal status. However, as with every stimulation protocol, 20% to 40% of the patients are cancelled before ovum pick-up mainly due to premature Luteinizing Hormone (LH) surge.

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References

  • Benadiva, C., Ben-Rafael, Z., Strauss, J.F., Mastroianni, L., and Flickinger G.L., 1988, Ovarian response of individuals to different dose of human menopausal gonadotropin, Fertil. Steril., 49:997.

    PubMed  Google Scholar 

  • Ben-Rafael, Z., Dor, J., Mashiach, S., Blankstein, J., Lunenfeld B., and Serr D.M., 1983, Abortion rate in pregnancies following ovulation induced by human menopausal gonadotropin/ human chorionic gonadotropin, Fertil Steril 39: 157.

    PubMed  CAS  Google Scholar 

  • Ben-Rafael, Z., Mastroianni, L., Strauss, J.F., and Flickinger G.L., 1986, Differences in ovarian stimulation in human menopausal gonadotropin treated women may be related to follicle stmulating hormone accumulation., Fertil Steril. 46: 486.

    Google Scholar 

  • Ben-Rafael, Z., Mastroianni, L., Meloni, F., Lee M.S., and Flickinger G.L., 1986, Total estradiol, free estradiol, sex hormone-binding globulin, and the fraction of estradiol bound to sex hormone binding globulin in human follicular fluid, J. Clin. Endocrinol. Metab., 63: 1106.

    Article  PubMed  CAS  Google Scholar 

  • Bider, D., Kokia, E., Lipitz, S., Blankstein, J., Mashiach, S, and Ben-Rafael, Z., Failure to improve ovarian response by combined GnRH agonist and gonadotropin therapy. (Submitted).

    Google Scholar 

  • Defazio J., Meldrum, D.R., Lu, J.K.H., Vale W.W., Rivier J.E., Judd, H.L., and Chang R.J., 1985, Acute ovarian response to long acting agonist of gonadotropin releasing hormone in ovulatory women and women with polycystic ovarian disease, Fertil. Steril., 44:453.

    PubMed  CAS  Google Scholar 

  • Fleming, R., Haxton, M.J., Hamileton, M.P.R., McCune, G.S. Black, W.B., Macnaughton, M.C., and Coutts, J.R.T., 1985, Successful treatment of infertile women with oligomenorrhea using a combination of LHRH agonist and exogenous gonadotropins, Br. J. Obstet. Gynecol 2: 368.

    Google Scholar 

  • Fleming, R., and Coutts, J.R.T.,1986, Induction of multiple follicular growth in normally menstruating women with endogenous gonadotropins suppression, Fertil. Steril., 45: 226.

    PubMed  CAS  Google Scholar 

  • Kenigsberg D., Littman, B.A., and Hodgen G.D., 1986, Induction of ovulation in primate models. Endocrine reviews, 7: 34.

    Article  PubMed  CAS  Google Scholar 

  • Lemay, A., Sandow, J., Quisnel, G., Bergeron, J., and Merat, P., 1988 Escape from down regulation of pituitary ovarian axis following decreased infusion of luteinizing hormone releasing hormone agonist, Fertil. Steril., 49: 802.

    PubMed  CAS  Google Scholar 

  • Mashiach, S., Dor, J., Goldenberg, M., Shalev, J., Blankstein, J., Rudak, E., Shoam, Z., Finelt, Z., Nebel, L., Goldman, B., and Ben-Rafael, Z., 1988, Protocols for induction of ovulation: The concept of programmed cycles, in: In vitro fertilization and other assisted reproduction, H.W. Jones, Jr. and C. Schrader., Eds., Annals. of N.Y. Acad. Sci., 541: 37.

    Google Scholar 

  • Popkin, R., Bramley, T.A., Currie, A., Shaw, R.W., Baird, D.T., Fraser, H.M. 1983, Specific binding of luitenising hormone releasing hormone to human luteal tissue. Biochem. Biophys. Res. Commun., 114:750.

    Article  PubMed  CAS  Google Scholar 

  • Radwanska, E., Rawlins, R.G., Turmmon, I., Maclin, V., Binor, Z., Damowski, W.P., 1988, Successful use of gonadotropin-releasing hormone agonist leuprolide for in vitro fertilization in a patient with polycystic ovarian disease and infertility unresponsive to standard treatment, Fertil. Steril. A 9: 356.

    Google Scholar 

  • Sandow, J., 1983, Clinical applications of LHRH and its analogues, Clin. Endocrinol., 18: 571.

    Article  CAS  Google Scholar 

  • Sheehan, K.L, Casper, R.F, Yen, S.S.C., 1983, Induction of luteolysis by luteinizing hormone releasing factor (LRF) agonist: Sensitivity, reproducibility, and reversibility, Fertil. Steril., 37:209.

    Google Scholar 

  • Smith, E.M., Anthony, F.W., Gadd, S.C, Mosson., G.M., 1989, Trial of support treatment with human menopausal gonadotropin in the luteal phase after treatment with buserelin and human menopausal gonadotropin in women taking part in an in vitro fertilisation programme, BMJ., 298:1483.

    Article  PubMed  CAS  Google Scholar 

  • Stucky, B.G.A., Klogh E.G., Pullan P.T., Beilby J.A., Thompson, R.J., and Evans O.V., 1987, Continous gonadotropin-releasing hormone for ovulation induction in polycystic ovarian disease, Fertil. Steril., 48:1055.

    Google Scholar 

  • Testart, J., Forman, R., Belaish-Alart, J.C., Volante, M., Hazut, A., Strub, N., and Frydman, R., 1989, Embryo quality and uterine receptivity in in vitro fertilization cycles with or without agonists of gonadotropin releasing hormone, Human. Reprod., 4:198.

    CAS  Google Scholar 

  • Torode, H.W., Porter, P.N., Vaughan, J.I., Saunders D.M., 1987, Luteal phase support after in vitro fertilisation: A trial and rationale for selective use, Clinc. Reprod. Fertil., 5:255.

    Google Scholar 

  • Wildt, L., Diedrich, K., Van der Ven, H., Hasani, S. Al., Huber, H., and Klasen, R., 1986, Ovarian hyperstimulation for in-vitro fertilization controlled by GnRH agonist administered in combination with human menopausal gonadotropin, Human. Reprod 1:15.

    CAS  Google Scholar 

  • Zeleznik, A.J., and Kubik C.J., 1986, Ovarian response in Macaques to pulsatile infusion of follicle-stimulating hormone (FSH) and luteinizing hormone: Increased sensitivity of maturing follicle to FSH, Endocrinology, 119:2025.

    Article  PubMed  CAS  Google Scholar 

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Shlomo Mashiach M.D. Zion Ben-Rafael M.D. Neri Laufer M.D. Joseph G. Schenker M.D.

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© 1990 Plenum Press, New York

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Ben-Rafael, Z. et al. (1990). Limitations in the Use of Combined Gonadotropin Releasing Hormone Analog and Human Menopausal Gonadotropin for In Vitro Fertilization. In: Mashiach, S., Ben-Rafael, Z., Laufer, N., Schenker, J.G. (eds) Advances in Assisted Reproductive Technologies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0645-0_2

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  • DOI: https://doi.org/10.1007/978-1-4613-0645-0_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7907-5

  • Online ISBN: 978-1-4613-0645-0

  • eBook Packages: Springer Book Archive

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