Skip to main content
SpringerLink
Log in

Regulation of Extrarenal Erythropoietin Production

  • Chapter
Molecular Biology of Erythropoiesis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 271))

Abstract

In 1953, Erslev1 discovered that the plasma of severely anemic rabbits containes a factor that is capable of increasing the rate of erythropoiesis of normal rabbits. Three years later, Jacobson et al2 reported that nephrectomy prevented the appearance of this factor (erythropoietin) in the plasma of anemic rats, and hypothesized that erythropoietin (Epo) is produced in the kidneys. The results of numerous studies, subsequently performed to test this hypothesis, provided substantial support for the concept that the kidneys are the primary organ of Epo production, but didn't negate the possibility that other organs could also produce Epo. Reports of detectable levels of bioactive Epo in the plasma of anephric neonatal rats3 and of intensly hypoxic anephric adult rats4,5 and rabbits6 indicated that extrarenal sites of Epo exist. The significance of extra-renally-produced Epo in humans was subsequently evidenced by the observations that erythropoiesis doesn't cease in anephric patients7 and that the plasma of extremely anemic, anephric, persons contain detectable amounts of Epo8,9.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. . Erslev, A.J. 1953. Humoral regulation of red cell production. Blood 8: 349 - 357.

    PubMed  CAS  Google Scholar 

  2. . Jacobson, L.O., E. Goldwasser, W. Fried, L. Plzak. 1957. Role of the kidney in erythropoiesis. Nature 179: 633 - 634.

    Article  PubMed  CAS  Google Scholar 

  3. . Carmena, A.O., D. Howard, F. Stohlman. 1968. Regulation of erythropoietin XXII. Production in the newborn animal. Blood 32: 376 - 382.

    PubMed  CAS  Google Scholar 

  4. . Mirand, E.A., T.C. Prentice. 1957. Presence of plasma erythropoietin in hypoxic rats with and without kidneys and/or spleen. Proc. Soc. Exp. Biol. Med. 96: 49 - 57.

    PubMed  CAS  Google Scholar 

  5. . Gallagher, N.I., J.M. McCarthy, R.D. Lange. 1961. Erythropoietin production in uremic rabbits. J. Lab. Clin. Med. 57: 281 - 289.

    PubMed  CAS  Google Scholar 

  6. . Erslev, A.J. 1958. Erythropoietin function in uremic rabbits. Arch. Int. Med. 101: 407 - 412.

    CAS  Google Scholar 

  7. . Nathan, D.G., E. Schupak, F. Stohlman. 1964. Erythropoiesis in anephric man. J. Clin. Invest. 43: 2158 - 2164.

    Article  PubMed  CAS  Google Scholar 

  8. . Mirand, E.A., G.P. Murphy, R.A. Steeves, H.W. Weber, F.P. Retief. 1968. Extrarenal production of erythropoietin in man. Acta.Haemat. 39: 359 - 365.

    Article  PubMed  CAS  Google Scholar 

  9. . Naets, J.P., N. Wittek. 1968. Presence of erythropoietin in the plasma of one anephric patient. Blood 31: 249 - 251.

    PubMed  CAS  Google Scholar 

  10. . Fried, W. 1972. The liver as a source of extrarenal erythropoietin. Blood 40: 671 - 677.

    PubMed  CAS  Google Scholar 

  11. Schooley, J.C., L.J. Mahlmann. 1974. Extrarenal erythropoietin production by the liver in the weaning rat. Proc. Soc. Exp. Biol. Med. 145: 1081 - 1083.

    Google Scholar 

  12. . Zanjani, E.D., J. Poster, L.M. Burlington, L.I. Mann, L.R. Wasserman. 1977. Liver as the primary site of erythropoietin formation in the fetus. J. Lab. Clin. Med. 89: 640 - 644.

    PubMed  CAS  Google Scholar 

  13. . Zanjani, E.D., J.L. Ascensao, P.B. McGlave, M. Banisadre, R.C. Ash. 1981. Studies on the liver to kidney switch of erythropoietin production. J. Clin. Invest. 67: 1183 - 1188.

    Article  PubMed  CAS  Google Scholar 

  14. . Wang, F., W. Fried. 1972. Renal and extrarenal erythropoietin production in male and female rats of various ages. J. Lab. Clin. Med. 79: 181 - 186.

    PubMed  CAS  Google Scholar 

  15. . Caro, J., L. Zon, R. Silver, O. Miller, A.J. Erslev. 1983. Erythropoietin in liver tissue extracts and in liver perfusates from hypoxic rats. Am. J. Physiol. 2224: E431 - 434.

    Google Scholar 

  16. . Fried, W., J. Barone-Varelas, T. Barone. 1982. The influence age and sex on erythropoietin titers in the plasma and tissue homogenates of hypoxic rats. Exp. Hematol 10: 472 - 477.

    CAS  Google Scholar 

  17. . Bondurant, M.D., M.J. Koury. 1986. Anemia induces accumulation of erythropoietin mRNA in the kidneys and liver. Mol. Cell Biol. 6: 2731 - 2733.

    CAS  Google Scholar 

  18. . Beru, N., J. McDonald, E. Goldwasser. 1987. Expression of the erythropoietin gene. Blood Cells 13: 263 - 268.

    PubMed  CAS  Google Scholar 

  19. . Paul, P., J.A. Rothmann, J.T. McMahon, A.S. Gordon. 1984. Erythropoietin secretion by isolated rat Kupffer cells. Exp. Hemat. 12: 825 - 830.

    CAS  Google Scholar 

  20. . Rich, I.N., W. Heit, B. Kubanek. 1982. Extrarenal erythropoietin production by macrophages. Blood 60: 1007 - 1018.

    PubMed  CAS  Google Scholar 

  21. . Fried, W., T. Kilbridge, S. Krantz, T.P. McDonald, R.D. Lange. 1969. Studies on extrarenal erythropoietin. J. Lab. Clin.Med. 73: 244 - 248.

    PubMed  CAS  Google Scholar 

  22. . Reissman, K.R. 1964. Protein metabolism and erythropoiesis, II. Erythropoietin formation and erythroid responsiveness in protein-deprived rats. Blood 23: 146 - 153.

    Google Scholar 

  23. . Anagnostou, A., S. Schade, M. Ashkinaz, J. Barone, W. Fried. 1977. Effect of protein deprivation on erythropoiesis. Blood 50: 1093 - 1977.

    PubMed  CAS  Google Scholar 

  24. . Anagnostou, A., S. Schade, J. Barone, W. Fried. 1978. Effect of protein deprivation on extrarenal erythropoietin production. Blood 51: 549 - 553.

    PubMed  CAS  Google Scholar 

  25. . Goldwasser, E., L.O. Jacobson, W. Fried, L. Pizak. 1958. Studies on erythropoiesis V. The effect of cobalt on the production of erythropoietin. Blood 13: 55 - 60.

    PubMed  CAS  Google Scholar 

  26. . Fried, W., T. Kilbridge. 1969. Effect of testosterone and cobalt on erythropoietin production in anephric rats. J. Lab Clin. Med. 74: 623 - 629.

    PubMed  CAS  Google Scholar 

  27. . Fried, W., C.W. Gurney. 1965. Erythropoietic effect of plasma from mice receiving testosterone. Nature 206: 1160 - 1161.

    Article  PubMed  CAS  Google Scholar 

  28. . Mirand, E.A., A.S. Gordon, J. Wenig. 1965. Mechanism of testosterone action on erythropoiesis. Nature 206: 270 - 272.

    Article  PubMed  CAS  Google Scholar 

  29. . Brown, S., J. Caro, A.J. Erslev, T. Murray. 1980. Spontaneous increase in EPO and hematocrit value associated with transient liver enzyme abnormalities in an anephric patient undergoing dialysis. Am. J. Med. 68: 280 - 283.

    Article  PubMed  CAS  Google Scholar 

  30. . Naughton, B.A., S.M. Kaplan, M. Roy, A.S. Gordon. 1977. Hepatic regeneration and erythropoietin production in the rat. Science 196: 301 - 302.

    Article  PubMed  CAS  Google Scholar 

  31. . Anagnostou, A., S. Schade, J. Barone, W. Fried. 1977. Effect of partial hepatectomy on extrarenal erythropoietin production in rats. Blood 50: 457 - 462.

    PubMed  CAS  Google Scholar 

  32. . Fried, W., J. Barone, S. Schade, A. Anagnostou. 1979. Effect of carbon tetrachloride on extrarenal erythropoietin production. J. Lab. Clin. Med. 93: 702 - 705.

    Google Scholar 

  33. . Fried, W. (In Press). Factors that affect the rate of erythropoietin production by extrarenal sites. Annals NY Acad, of Sciences.

    Google Scholar 

  34. . Peschle, C, G. Marone, A. Genovese, I.A. Rappaport, M. Condorelli. 1976. Increased erythropoietin production in anephric rats with hyperplasia of the reticuloendothelial system induced by colloidal carbon or zymosan. Blood 147: 325 - 337.

    Google Scholar 

  35. . Fried, W., J. Barone-Varelas, T. Barone, A. Anagnostou. 1982. Effect of angiotensin infusion on extrarenal erythropoietin production. J. Lab. Clin. Med. 99: 520 - 525.

    PubMed  CAS  Google Scholar 

  36. Schooley, J.C., L.J. Mahlmann. 1972. Erythropoietin production in the anephric rat 1. relationship between nephrectomy and time of hypoxic exposure and erythropoietin production. Blood 33: 31 - 38.

    Google Scholar 

  37. . Peschle, C., G.F. Sasso, I.A. Rappaport, M. Condorelli. 1972. Erythropoietin production in nephrectomized rats: possible role of the renal erythropoietic factor. J. Lab. Clin. Med. 79: 950 - 959.

    PubMed  CAS  Google Scholar 

  38. . Gould, A.B., S.A. Goodman, D. Green. 1973. An in-vivo effect of renin on erythropoietin formation. Lab. Invest. 28: 719 - 722.

    CAS  Google Scholar 

  39. . Anagnostou, A., R. Baranowski, V.K.G. Pillay, N. Kurtzmann, G. Vercellotti, W. Fried. 1976. Effect of renin on extrarenal erythropoietin production. J. Clin. Med. 88: 707 - 715.

    CAS  Google Scholar 

  40. . Fried, W., J. Barone-Varelas, C. Morley. 1984. Factors that regulate extrarenal erythropoietin production. Blood Cells 10: 287 - 304.

    PubMed  CAS  Google Scholar 

  41. . Malgor, L.A., J.W. Fisher. 1969. Antagonism of angiotensin by hydralazine on renal blood flow and erythropoietin production. Am. J. Physiol. 216: 563 - 566.

    PubMed  CAS  Google Scholar 

  42. . Dukes, P.P., N.A. Shore, D. Hammond, J. Ortega, M.C. Data. 1973. Enhancement of erythropoiesis by prostaglandins. J. Lab. Clin. Med. 82: 704 - 712.

    PubMed  CAS  Google Scholar 

  43. Schooley, J.C., L.J. Mahlmann. 1978. Stimulation of erythropoiesis in plethoric mice by prostaglandins and its inhibition by anti-erythropoietin. Proc. Soc. Exp. Biol. Med. 138: 523 - 524.

    Google Scholar 

  44. Naughton, B.A., G.K. Naughton, P. Liu, J.M. Arce, S. Pilero, A.S. Gordon. 1982. The effects of prostaglandins on extrarenal erythropoietin production. Proc. Soc. Exp. Biol. Med. 170: 231 - 236.

    Google Scholar 

  45. Fried, W., C. Morley, J. Barone-Varelas, A. Bidani, A. Prancan. 1988. Effect of indomethacin and of prostaglandins on extrarenal erythropoietin production. J. Lab. Clin. Med. Ill: 184 - 188.

    Google Scholar 

  46. Gross, D.M., W. Jubiz, J.W. Fisher. 1977. Released erythropoietin and prostaglandin E by the dog kidney during hypoxic hypoxia and the effect of indomethacin. Fed. Proc. 36: 1052.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Rush-Presbyterian, St. Luke's Medical Center, Chicago, IL, 60612, USA

    Walter Fried

Authors
  1. Walter Fried
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Connecticut Health Center, Farmington, Connecticut, USA

    Joao L. Ascensao

  2. Veterans Administration Medical Center, Reno, Nevada, USA

    Esmail D. Zanjani

  3. Veterans Administration Hospital, Jackson, Mississippi, USA

    Mehdi Tavassoli

  4. National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

    Alan S. Levine

  5. University of Nevada, Reno, Nevada, USA

    F. Roy MacKintosh

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Fried, W. (1989). Regulation of Extrarenal Erythropoietin Production. In: Ascensao, J.L., Zanjani, E.D., Tavassoli, M., Levine, A.S., MacKintosh, F.R. (eds) Molecular Biology of Erythropoiesis. Advances in Experimental Medicine and Biology, vol 271. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0623-8_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-0623-8_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7897-9

  • Online ISBN: 978-1-4613-0623-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation