Regulation of Extrarenal Erythropoietin Production

  • Walter Fried
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 271)

Abstract

In 1953, Erslev1 discovered that the plasma of severely anemic rabbits containes a factor that is capable of increasing the rate of erythropoiesis of normal rabbits. Three years later, Jacobson et al2 reported that nephrectomy prevented the appearance of this factor (erythropoietin) in the plasma of anemic rats, and hypothesized that erythropoietin (Epo) is produced in the kidneys. The results of numerous studies, subsequently performed to test this hypothesis, provided substantial support for the concept that the kidneys are the primary organ of Epo production, but didn't negate the possibility that other organs could also produce Epo. Reports of detectable levels of bioactive Epo in the plasma of anephric neonatal rats3 and of intensly hypoxic anephric adult rats4,5 and rabbits6 indicated that extrarenal sites of Epo exist. The significance of extra-renally-produced Epo in humans was subsequently evidenced by the observations that erythropoiesis doesn't cease in anephric patients7 and that the plasma of extremely anemic, anephric, persons contain detectable amounts of Epo8,9.

Keywords

Hepatitis Cobalt Anemia Testosterone Angiotensin 

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Walter Fried
    • 1
  1. 1.Rush-PresbyterianSt. Luke's Medical CenterChicagoUSA

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