Abstract
The studies described in this paper were directed at an understanding of the regulation of heme synthesis during erythropoietin (epo)-induced erythroid differentiation. Although considerable work has been done on the regulation of heme synthesis in virally—transformed erythroid cell lines which were chemically induced to differentiate along the erythroid pathway1–4 our goal was to study the control of heme formation in normal bone marrow cells, the physiological site of epo action. Our earlier findings showing that heme synthesis is required for the epo-induced globin synthesis in marrow cells5, made this an important problem.
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© 1989 Plenum Press, New York
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Beru, N., Goldwasser, E. (1989). Studies of the Effect of Erythropoietin on Heme Synthesis. In: Ascensao, J.L., Zanjani, E.D., Tavassoli, M., Levine, A.S., MacKintosh, F.R. (eds) Molecular Biology of Erythropoiesis. Advances in Experimental Medicine and Biology, vol 271. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0623-8_10
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DOI: https://doi.org/10.1007/978-1-4613-0623-8_10
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