Modeling the Effect of Sleep-State on Respiratory Stability

  • Michael C. K. Khoo

Abstract

The recognition that sleep significantly lowers resting ventilation and alters breathing pattern dates back to studies published in the nineteenth century1–4. Mosso4 noted a tendency in sleeping subjects to exhibit a periodic waxing and waning of respiration, similar to the pattern seen during Cheyne-Stokes breathing. Magnussen5 suggested a connection between this phenomenon and the alternating periods of wakefulness and sleep that he observed. Subsequently, with the use of electroencephalography, Aserinsky and Kleitman6 revealed the existence of rapid-eye-movement (REM) sleep and found that these periods were associated with a marked increase in respiratory variability. Bulow7 showed that periodic breathing (PB) often occurred during drowsiness and light NREM sleep, but in the deeper stages of NREM sleep (or slow-wave sleep (SWS)), ventilation became highly regular. These findings have been confirmed by others8,9. However, in some reports10,11, PB has been found to occur during REM sleep as well.

Keywords

Attenuation Respiration Tate Kelly Haldane 

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References

  1. 1.
    E. Smith, Recherches experimentales sur la respiration, Journal Physiologie de PHomme et des Animaux 3: 506–521 (1860).Google Scholar
  2. 2.
    A. Mosso, Uber die gegenseitigen Beziehungen der Bauch- und Brustathmung, Arch. Anat. Physiol. 2:441–468 (1878).Google Scholar
  3. 3.
    A. Czerny, Beobachtungen über den Schlaf im Kindesalter unter physiologischen Verhalt nissen, Jahrb. Kinderheilk. 33:1–28 (1892).Google Scholar
  4. 4.
    A. Mosso, Respiration on the mountains, in: “Life of Man on the High Alps”, Fisher- Unwin, London (1898).Google Scholar
  5. 5.
    G. Magnussen, “Studies on the Respiration During Sleep”, Lewis, London (1944).Google Scholar
  6. 6.
    E. Aserinsky and N. Kleitman, Regularly occurring periods of eye motility, and concomitant phenomena, during sleep, Science 118: 273 - 274 (1953).Google Scholar
  7. 7.
    K. Bulow, Respiration and wakefulness in man, Acta Physiol. Scand. Suppl. 209 (1963).Google Scholar
  8. 8.
    E. Lugaresi, G. Coccagna, F. Cirignotta, P. Farneti, R. Gallassi, G. Di Donato and P. Verucchi, Breathing during sleep in man in normal and pathological conditions, in: “The Regulation of Respiration during Sleep and Anesthesia”, R.S. Fitzgerald, H. Gautier and S. Lahiri, ed., Plenum, New York (1977).Google Scholar
  9. 9.
    E.A. Phillipson and G. Bowes, Control of breathing during sleep, in: “Handbook of Physiology - The Respiratory System II”, A.P. Fishman, ed., Am. Physiol. Soc., Bethesda, MD (1987).Google Scholar
  10. 10.
    P. Webb, Periodic breathing during sleep, J. Appl. Physiol. 37:899–903 (1974).PubMedGoogle Scholar
  11. 11.
    E. Aserinsky, Periodic respiratory pattern occurring in conjunction with eye movements during sleep, Science 150: 763–766 (1965).Google Scholar
  12. 12.
    M.C.K. Khoo, A model for respiratory variability during non-REM sleep, in: “Respiratory Control: Modelling Perspective”, G.D. Swanson, F.S. Grodins and R.L. Hughson, eds., Plenum, N.Y. (1989).Google Scholar
  13. 13.
    M.C.K. Khoo, R.E. Kronauer, K.P. Strohl and A.S. Slutsky, Factors inducing periodic breathing in humans: a general model, J. Appl. Physiol. 53:644–659 (1982).PubMedGoogle Scholar
  14. 14.
    K.R. Chapman, E.N. Bruce, B. Gothe and N.S. Cherniack, Possible mechanisms of periodic breathing during sleep, J. Appl. Physiol. 64:1000–1008 (1988).PubMedCrossRefGoogle Scholar
  15. 15.
    W.W. Pryor, Cheyne-Stokes respiration in patients with cardiac enlargement and prolonged circulation time, Circulation 4: 233–238 (1951).Google Scholar
  16. 16.
    D.C. Shannon, D.W. Carley and D.H. Kelly, Periodic breathing: Quantitative analysis and clinical description, Pediatr. Pulmonol. 4:98–102 (1988).PubMedCrossRefGoogle Scholar
  17. 17.
    B.R. Fink, Influence of cerebral activity in wakefulness on regulation of breathing, L Appl. Physiol. 16:15–20 (1961).Google Scholar
  18. 18.
    J.A. Dempsey and J.B. Skatrud, A sleep-induced apneic threshold and its consequences, Am. Rev. Respir. Pis. 133:1163–1170 (1986).Google Scholar
  19. 19.
    N.S. Cherniack, Respiratory dysrhythmias in sleep, N. Engl. J. Med. 305:325–330 (1981).PubMedCrossRefGoogle Scholar
  20. 20.
    J.S. Haldane, “Respiration”, Yale Univ. Press, New Haven, CT (1922).Google Scholar
  21. 21.
    P.J. Brusil, “Statistical analysis of natural breathing patterns in supine manx”, ( Ph.D. thesis) Harvard Univ., Cambridge, MA (1973).Google Scholar
  22. 22.
    P.J. Brusil, T.B. Waggener, R.E. Kronauer and P. Gulesian Jr., Methods for identifying respiratory oscillations disclose altitude effects, J. Appl. Physiol. 48:545–556 (1980).PubMedGoogle Scholar
  23. 23.
    G.S. Longobardo, B. Gothe, M.D. Goldman and N.S. Cherniack, Sleep apnea considered as a control system instability, Respir. Physiol. 50:311–333 (1982).PubMedCrossRefGoogle Scholar
  24. 24.
    K.P. Strohl, N.S. Cherniack and B. Gothe, Physiologic basis of therapy for sleep apnea, Am. Rev. Respir. Pis. 134:791–802 (1986).Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Michael C. K. Khoo
    • 1
  1. 1.Biomedical Engineering Dept.University of Southern CaliforniaLos AngelesUSA

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